Eccentric Cycling ExerciseNCT06480656
Eccentric Cycling Exercise During Pulmonary Rehabilitation Pulmonary Vascular Disease
A study testing Rehabilitation with eccentric cycling exercise and normal rehabilitation in people with Eccentric Cycling Exercise, run by University of Zurich at 2 sites in Switzerland.
Trial summary
Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Eccentric Cycling Exercise
- What is being tested?
- Rehabilitation with eccentric cycling exercise and normal rehabilitation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 2 sitesSwitzerland
- Study dates
- 29 May 2024to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosed with PVD, either PAH or CTEPH according to recent guidelines
- Stable medication for at least 1 month
- Age 18 to 85 years
- No resting hypoxemia (PaO2 >7.3kPa)
Who cannot join
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
Trial locations and contacts
2 sites in 1 country.
Switzerland2 sites
Rehabilitation clinic Barmelweid
Erlinsbach, 5017
University Hospital Zurich, Pneumology
Zurich
About this study
Official title: Eccentric Cycling Exercise During Pulmonary Rehabilitation in Pulmonary Vascular Disease
Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD
Read the detailed description
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease.
Furthermore, the investigators conducted an RCT in which the investigators exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle.
Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD.
- Conditions
- Eccentric Cycling Exercise
- Being tested
- Rehabilitation with eccentric cycling exercise, normal rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Rehabilitation with eccentric cycling exerciseProcedure or surgery
Instead of normal cycling, patients will exercise on the eccentric bike.
normal rehabilitationProcedure or surgery
Normal rehabilitation will be conducted
| Study group | Role | What they receive |
|---|---|---|
| Eccentric cycling exercise | Experimental | Not described Receives: Procedure: Rehabilitation with eccentric cycling exercise |
| Concentric cycling exercise | Active comparator | Not described Receives: Procedure: normal rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
peak exercise capacity
Measured: 3 weeks
Secondary outcomes (16)
Peak oxygen uptake
Assesses during exercise until exhaustion using an incremental exercise protocol
Measured: 3 weeks
ventilatory equivalent for CO2
Measured: 3 weeks
Finger pulseoximetry
Arterial oxygen saturation will be assessed by finger clip Infrared spectroscopy
Measured: 3 weeks
6 minute walk distance
Measured: 3 weeks
systolic pulmonary artery pressure
Measured: 3 weeks
total pulmonary resistance
Measured: 3 weeks
ventricular - pulmonary arterial coupling
Measured: 3 weeks
cardiac output
will be assessed by echocardiography using the pulse-wave doppler technique at the left ventricular outflow tract durig systole.
Measured: 3 weeks
Arterial partial pressure for oxygen
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Measured: 3 weeks
Arterial partial pressure for carbon dioxide
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Measured: 3 weeks
Arterial oxygen saturation
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Measured: 3 weeks
Arterial lactate concentration
Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Measured: 3 weeks
Borg CR 10 for perceived dyspnea
Measured: 3 weeks
Borg CR 10 for perceived leg fatigue
Measured: 3 weeks
Visual analogue scale generell well being
Measured: 3 weeks
Visual analogue scale dyspnea
Measured: 3 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jun 2024
- Study start29 May 2024
- Primary completion1 Jun 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eccentric Cycling ExerciseStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Silvia Ulrich Somaini, University of Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06480656
- Sponsor's protocol ID
- EccRehab
- Status last verified
- Jul 2026
- First submitted
- 31 May 2024
- Last updated
- 7 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Eccentric Cycling Exercise During Pulmonary Rehabilitation in Pulmonary Vascular Disease
- ClinicalTrials.gov ID
- NCT06480656
- Acronym / sponsor ID
- EccRehab
- Conditions
- Eccentric Cycling Exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- 29 May 2024 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 28 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD
Detailed description
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease.
Furthermore, the investigators conducted an RCT in which the investigators exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle.
Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Eccentric cycling exercise | Experimental | Procedure: Rehabilitation with eccentric cycling exercise |
| Concentric cycling exercise | Active comparator | Procedure: normal rehabilitation |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Diagnosed with PVD, either PAH or CTEPH according to recent guidelines
- Stable medication for at least 1 month
- Age 18 to 85 years
- No resting hypoxemia (PaO2 >7.3kPa)
Key exclusion criteria (2 listed)
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Rehabilitation with eccentric cycling exerciseInstead of normal cycling, patients will exercise on the eccentric bike. | Procedure or surgery | Eccentric cycling exercise |
| normal rehabilitationNormal rehabilitation will be conducted | Procedure or surgery | Concentric cycling exercise |
Primary outcome
peak exercise capacity
Time frame: 3 weeks
16 secondary outcomes
Peak oxygen uptake
Time frame: 3 weeks
ventilatory equivalent for CO2
Time frame: 3 weeks
Finger pulseoximetry
Time frame: 3 weeks
6 minute walk distance
Time frame: 3 weeks
systolic pulmonary artery pressure
Time frame: 3 weeks
total pulmonary resistance
Time frame: 3 weeks
ventricular - pulmonary arterial coupling
Time frame: 3 weeks
cardiac output
Time frame: 3 weeks
Arterial partial pressure for oxygen
Time frame: 3 weeks
Arterial partial pressure for carbon dioxide
Time frame: 3 weeks
Arterial oxygen saturation
Time frame: 3 weeks
Arterial lactate concentration
Time frame: 3 weeks
Borg CR 10 for perceived dyspnea
Time frame: 3 weeks
Borg CR 10 for perceived leg fatigue
Time frame: 3 weeks
Visual analogue scale generell well being
Time frame: 3 weeks
Visual analogue scale dyspnea
Time frame: 3 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Eccentric Cycling Exercise
Enrolling by invitation
Effectiveness of Eccentric Cycling Exercise in Ambulatory Rehabilitation for Patients With Cardiopulmonary Diseases: A Pragmatic Randomized Controlled Trial
Eccentric Cycling Exercise Training
Not yet recruiting
Eccentric Exercise Rehabilitation After Myocardial Infarction
Myocardial Infarction (MI), Cardiac Rehabilitation
Not yet recruiting
Long-Term Benefits of Eccentric Cycling Exercise in Patients With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM)
Recruiting
The Effects of Eccentric Cycling Exercise Program in Chronic Kidney Disease Patients
Chronic Kidney Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Rehabilitation with eccentric cycling exercise and normal rehabilitation in people with Eccentric Cycling Exercise, run by University of Zurich at 2 sites in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
peak exercise capacity (time frame: 3 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.