MisinformationNCT06947187
Vaccine Confidence and Infodemic in Southeast Asia's Nusantara Sociocultural Sphere
A study testing Pre-bunking video and Video on safe disposal of medication in people with Misinformation, run by University of California, Berkeley at 1 site in United States.
Trial summary
The goal of this clinical trial is to understand how well a culturally-specific "prebunking" video can improve vaccine information literacy and vaccine confidence among individuals in the Nusantara sociocultural sphere. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Misinformation
- What is being tested?
- Pre-bunking video and Video on safe disposal of medication
- Type of treatment
- Vaccines
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 472 participants
- Where
- 1 siteUnited States
- Study dates
- 28 Dec 2024to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- At least 18 years old
- Live in Brunei, Indonesia, Malaysia, or Singapore
- Fluent in Bahasa Melayu or Bahasa Indonesia
- Watch social media content in Bahasa Melayu or Bahasa Indonesia every day
- Access to stable Internet on smartphone or laptop to complete the experiment without interruption
Who cannot join
- Individuals who were involved in the online human-centered design thinking workshops or the in-person focus-group discussions will not be eligible to participate in RCT. This exclusion criterion is put in place to prevent potential bias in the evaluation of the intervention's effectiveness.
- Individuals who have difficulty in looking at social media on cellphone (even when they use prescription glasses), listening to the audio of social media content on cellphone (even with hearing aid), and typing within or engaging with social media content on cell phone are not eligible to participate in this study. -
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of California, Berkeley
Berkeley, California, 94720
Laura H Kwong, PhD, 650-460-9593, lakwong@berkeley.edu
About this study
Official title: Vaccine Confidence and Infodemic in Southeast Asia's Nusantara Sociocultural Sphere: A Transdisciplinary, Transnational Study
The goal of this clinical trial is to understand how well a culturally-specific "prebunking" video can improve vaccine information literacy and vaccine confidence among individuals in the Nusantara sociocultural sphere. The investigators hypothesize the individuals who watch the co-created "prebunking" intervention video will have improved vaccine literacy skills and vaccine confidence compared to individuals who watch a video about safe medication disposal.
Read the detailed description
The primary aim of this research is to develop and assess the impact of an educational video in enhancing vaccine information literacy and vaccine confidence within Southeast Asia's Nusantara Sociocultural Sphere--a network of communities spanning multiple countries in Southeast Asia, connected by shared linguistic, historical, and sociocultural roots. Adopting a transdisciplinary and human-centered approach, we will engage representatives from Brunei, Indonesia, Malaysia and Singapore through online workshops and in-person focus group discussions to co-create a video. Guided by the findings from our research (using publicly available social media dataset) and communication theories from existing literature, the video will contain messages that focus on equipping viewers with the skills to identify common tactics used in vaccine misinformation in two mutually intelligible languages (Bahasa Melayu and Bahasa Indonesia) and on enhancing vaccine confidence levels among viewers.
To evaluate the effectiveness of the videos as an intervention for vaccine information literacy and vaccine confidence, we will conduct an online two-arm randomized controlled trial (RCT). Participants will be randomly assigned to one of the two groups:
- Group 1 (Intervention Group): Participants will watch the co-created video containing vaccine-related messages.
- Group 2 (Control Group): Participants will watch a control video containing messages related to the importance of proper and safe medication disposal.
We hypothesize that exposure to Video 1 will lead to a significant increase in vaccine literacy skills and vaccine confidence compared to exposure to Video 2.
The study will be conducted online. Individuals who have signed the e-consent form will be automatically redirected to the online RCT. Each participant will be asked to respond to several pre-video questions (including demographic, vaccine confidence, and vaccine literacy). After stratification by language, they will be randomly assigned to watch either the control video (physical exercise) or intervention video (vaccine) using REDCap's randomization functionality. After watching the video, they will respond to post-video questions (including behavior, vaccine confidence, and vaccine literacy). They will then undergo debriefing, which aims to clarify which social media posts (embedded in vaccine literacy-related questions) contain misinformation AND to provide full disclosure on the goal of the RCT (which was partially disclosed during recruitment to avoid confusion). Finally, each participant will be asked if they are interested to participate in a gift card drawing -- if they are, the investigators will asked them to share their name and contact information. The UCB team will monitor data collection and stop data collection when the target number of participants has been reached.
Within two weeks of closing the RCT data collection, the UCB team will draw 40 names from a pool of participants who have successfully completed the experiment and have agreed to participate in the drawing for gift cards. 20 out of 40 selected participants will be from the Bahasa Melayu-speaking pool; the other 20 from the Bahasa Indonesia-speaking pool.
- Conditions
- Misinformation
- Being tested
- Pre-bunking video, Video on safe disposal of medication
- Keywords
- Misinformation, Bahasa, Vaccine confidence, Vaccine literacy, Video intervention
- Medical subject headings
- Communication
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pre-bunking videoOther
~3 minutes educational video to improve vaccine literacy and vaccine confidence
Video on safe disposal of medicationOther
~3 minutes educational video on safe disposal of medication
| Study group | Role | What they receive |
|---|---|---|
| Watch pre-bunking video | Experimental | Participants in this arm will watch a ~3-minute pre-bunking video Receives: Other: Pre-bunking video |
| Watch video on safe disposal of medication | Placebo comparator | Participants in this arm will watch a ~3-minute video that discusses safe ways to dispose of medication Receives: Other: Video on safe disposal of medication |
What is being measured
The primary outcome is the main question the study is designed to answer.
Identification of vaccine misinformation
The percent of social media posts that the participant correctly identifies as misinformation
Measured: From the start to the end of the survey (approximately 20 minutes)
Secondary outcomes (1)
Vaccine confidence
The participant's stated vaccine confidence on a Likert scale
Measured: From the start to the end of the survey (approximately 20 minutes)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Apr 2025
- Study start28 Dec 2024
- Primary completion31 Dec 2025 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MisinformationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 472 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, Berkeley
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Laura (Layla) H Kwong, University of California, Berkeley
- Investigators
- Laura H Kwong, Principal investigator, University of California, Berkeley
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06947187
- Sponsor's protocol ID
- 2023-06-16452
- Status last verified
- Apr 2025
- First submitted
- 6 Jan 2025
- Last updated
- 27 Apr 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Vaccine Confidence and Infodemic in Southeast Asia's Nusantara Sociocultural Sphere: A Transdisciplinary, Transnational Study
- ClinicalTrials.gov ID
- NCT06947187
- Acronym / sponsor ID
- 2023-06-16452
- Conditions
- Misinformation
- Keywords
- Misinformation, Bahasa, Vaccine confidence, Vaccine literacy, Video intervention
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 472 participants (estimated)
- Lead sponsor
- University of California, BerkeleyUniversity, hospital or other
- Study start
- 28 Dec 2024 (actual)
- Primary completion
- 31 Dec 2025 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 27 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to understand how well a culturally-specific "prebunking" video can improve vaccine information literacy and vaccine confidence among individuals in the Nusantara sociocultural sphere. The investigators hypothesize the individuals who watch the co-created "prebunking" intervention video will have improved vaccine literacy skills and vaccine confidence compared to individuals who watch a video about safe medication disposal.
Detailed description
The primary aim of this research is to develop and assess the impact of an educational video in enhancing vaccine information literacy and vaccine confidence within Southeast Asia's Nusantara Sociocultural Sphere--a network of communities spanning multiple countries in Southeast Asia, connected by shared linguistic, historical, and sociocultural roots. Adopting a transdisciplinary and human-centered approach, we will engage representatives from Brunei, Indonesia, Malaysia and Singapore through online workshops and in-person focus group discussions to co-create a video. Guided by the findings from our research (using publicly available social media dataset) and communication theories from existing literature, the video will contain messages that focus on equipping viewers with the skills to identify common tactics used in vaccine misinformation in two mutually intelligible languages (Bahasa Melayu and Bahasa Indonesia) and on enhancing vaccine confidence levels among viewers.
To evaluate the effectiveness of the videos as an intervention for vaccine information literacy and vaccine confidence, we will conduct an online two-arm randomized controlled trial (RCT). Participants will be randomly assigned to one of the two groups:
- Group 1 (Intervention Group): Participants will watch the co-created video containing vaccine-related messages.
- Group 2 (Control Group): Participants will watch a control video containing messages related to the importance of proper and safe medication disposal.
We hypothesize that exposure to Video 1 will lead to a significant increase in vaccine literacy skills and vaccine confidence compared to exposure to Video 2.
The study will be conducted online. Individuals who have signed the e-consent form will be automatically redirected to the online RCT. Each participant will be asked to respond to several pre-video questions (including demographic, vaccine confidence, and vaccine literacy). After stratification by language, they will be randomly assigned to watch either the control video (physical exercise) or intervention video (vaccine) using REDCap's randomization functionality. After watching the video, they will respond to post-video questions (including behavior, vaccine confidence, and vaccine literacy). They will then undergo debriefing, which aims to clarify which social media posts (embedded in vaccine literacy-related questions) contain misinformation AND to provide full disclosure on the goal of the RCT (which was partially disclosed during recruitment to avoid confusion). Finally, each participant will be asked if they are interested to participate in a gift card drawing -- if they are, the investigators will asked them to share their name and contact information. The UCB team will monitor data collection and stop data collection when the target number of participants has been reached.
Within two weeks of closing the RCT data collection, the UCB team will draw 40 names from a pool of participants who have successfully completed the experiment and have agreed to participate in the drawing for gift cards. 20 out of 40 selected participants will be from the Bahasa Melayu-speaking pool; the other 20 from the Bahasa Indonesia-speaking pool.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Watch pre-bunking video | Experimental | Other: Pre-bunking videoParticipants in this arm will watch a ~3-minute pre-bunking video |
| Watch video on safe disposal of medication | Placebo comparator | Other: Video on safe disposal of medicationParticipants in this arm will watch a ~3-minute video that discusses safe ways to dispose of medication |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- At least 18 years old
- Live in Brunei, Indonesia, Malaysia, or Singapore
- Fluent in Bahasa Melayu or Bahasa Indonesia
- Watch social media content in Bahasa Melayu or Bahasa Indonesia every day
- Access to stable Internet on smartphone or laptop to complete the experiment without interruption
Key exclusion criteria (2 listed)
- Individuals who were involved in the online human-centered design thinking workshops or the in-person focus-group discussions will not be eligible to participate in RCT. This exclusion criterion is put in place to prevent potential bias in the evaluation of the intervention's effectiveness.
- Individuals who have difficulty in looking at social media on cellphone (even when they use prescription glasses), listening to the audio of social media content on cellphone (even with hearing aid), and typing within or engaging with social media content on cell phone are not eligible to participate in this study. -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pre-bunking video~3 minutes educational video to improve vaccine literacy and vaccine confidence | Other | Watch pre-bunking video |
| Video on safe disposal of medication~3 minutes educational video on safe disposal of medication | Other | Watch video on safe disposal of medication |
Primary outcome
Identification of vaccine misinformation
Time frame: From the start to the end of the survey (approximately 20 minutes)
The percent of social media posts that the participant correctly identifies as misinformation
1 secondary outcome
Vaccine confidence
Time frame: From the start to the end of the survey (approximately 20 minutes)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Apr 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Laura H Kwong principal investigator
University of California, Berkeley
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pre-bunking video and Video on safe disposal of medication in people with Misinformation, run by University of California, Berkeley at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Laura H Kwong, PhD (+1-650-332-4667, lakwong@berkeley.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Identification of vaccine misinformation (time frame: From the start to the end of the survey (approximately 20 minutes)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Apr 2025.