Lumbar Disc HerniationNCT07203560
Effect of Neurodynamic Mobilization in Patients With Lumbar Disc Herniation
A study testing Neurodynamic Mobilization and Conventional Physiotherapy in people with Lumbar Disc Herniation and Low Back Pain, run by Aydin Adnan Menderes University at 1 site in Turkey (Türkiye).
Trial summary
The objective of this randomized controlled trial was to investigate the effects of neurodynamic mobilization on pain intensity, normal joint motion, neurodynamics, functional level, and disability in patients with lumbar disc herniation. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Lumbar Disc Herniation, Low Back Pain
- What is being tested?
- Neurodynamic Mobilization and Conventional Physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 4 Jun 2018to 10 May 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age between 20 and 60 years
- Diagnosed with lumbar disc herniation at one or more of the L3-L4, L4-L5
- L5-S1 levels with prolapsed, protruding, or extruding disc confirmed by MRI
- Presence of low back pain for at least 6 weeks.
Who cannot join
- Spinal stenosis
- Previous lumbar surgery or medical treatment for disc herniation
- Pregnancy
- Severe osteoporosis
- Diabetes mellitus
- Severe neurological deficit
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Gazi University Department of Physical Therapy and Rehabilitation
Ankara, Çankaya, 06690
About this study
Official title: Neurodynamic Mobilization for the Management of Patients With Lumbar Disc Herniation: A Randomized Controlled Study
The objective of this randomized controlled trial was to investigate the effects of neurodynamic mobilization on pain intensity, normal joint motion, neurodynamics, functional level, and disability in patients with lumbar disc herniation.
Read the detailed description
Background: Low back pain is a major cause of disability worldwide, and due to the limited effectiveness of current treatments, this study aimed to evaluate the efficacy of neurodynamic mobilization technique on pain intensity, range of motion, neurodynamics, functional status, and disability in patients.
Methods: Thirty-seven patients were randomized to control or mobilization group. Participants in the control group received a conventional therapy for 20 treatment sessions, and those in the mobilization group were treated neurodynamic mobilization in addition to the electro/thermal therapy program twice a week for 4 consecutive weeks. Pain level at rest and during activity was recorded with a Visual Analog Scale. Active lumbar flexion, extension, and lateral flexion were measured with a universal goniometer. Neurodynamic mobility was evaluated using neurodynamic tests. The functional status was assessed with the 30-second chair stand test and disability was evaluated with the Bournemouth Questionnaire. 2x2 repeated measures ANOVA models were used to determine within and between group differences.
- Conditions
- Lumbar Disc Herniation, Low Back Pain
- Being tested
- Neurodynamic Mobilization, Conventional Physiotherapy
- Keywords
- low back pain, sciatica, Disability Evaluation, Musculoskeletal Manipulations
- Medical subject headings
- Intervertebral Disc Displacement, Low Back Pain, Sciatica
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neurodynamic MobilizationOther
In the experimental group, neurodynamic mobilization was applied in addition to the conventional physiotherapy program. For the neurodynamic mobilization tibial nerve neural mobilization was performed. For neural mobilization of the tibial nerve, the patient was placed in the side-lying position with the hip in 90° flexion, knee flexion and ankle dorsi flexion. In this position, the ankle and hip positions were maintained, and knee extension was performed. When the symptoms were at a level that would not disturb the patient, it was held for 5 seconds, and knee flexion was performed by plantar flexion of the ankle. This practice was performed twice a week with 10 repetitions by a physiotherapist. The same neurodynamic mobilization exercise was recommended to the patients in the neuromobilization group as a home program with 10 repetitions twice a day.
Conventional PhysiotherapyOther
All participants received hot pack therapy (20 minutes), conventional TENS (60 Hz, 60 msec, 20 minutes), therapeutic ultrasound (1.5 W/cm², 10 minutes), and a prescribed home exercise program, delivered 5 days per week for 4 weeks (20 sessions in total).
| Study group | Role | What they receive |
|---|---|---|
| Neurodynamic Mobilization + Conventional Therapy (Experimental Group) | Experimental | Participants received the conventional physiotherapy program plus neurodynamic mobilization administered by a physical therapist. Treatment was given 5 days a week for 4 weeks, for a total of 20 sessions. Receives: Other: Neurodynamic Mobilization; Other: Conventional Physiotherapy |
| Conventional Therapy (Control Group) | Active comparator | Individuals in control group received hot therapy (Hotpack, 20 minutes), Conventional Tens (60 Hz, 60 msec, 20 minutes) and Therapeutic Ultrasound (1.5 w/cm2, 10 minutes). Patients were given an exercise program to do at home and the treatment was given 5 days a week for 4 weeks, for a total of 20 sessions, to all patients in the study. Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Intensity
Patients' rest and activity pain levels was assessed via a visual analog scale (VAS). Participants were asked to mark the intensity of pain they felt on a 10-centimeter (cm) horizontal line (0 indicates no pain, 10 indicates intolerable pain). The point marked on the line was measured with a ruler and the VAS value was recorded in cm
Measured: Pain was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)
Secondary outcomes (3)
ROM
Rom of the lumbar region was evaluated using a universal goniometer. Lumbar flexion and extension, right and left lateral trunk flexion were measured actively and recorded in terms of degree.
Measured: Rom was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).
Neurodynamic Mobility - Slump Test
Slump test The patient was asked to sit on the edge of the examination table with the knee flexed at 90° and to flex the neck, back, and lower back respectively. He was then asked to bring his big toe towards his head by extending the knee. In this position, the angle between the starting position and the fibula was measured with a universal goniometer. The test was repeated twice and the mean degree was recorded.
Measured: These were assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).
Neurodynamic Mobility - Sit and Reach Test
Sit and Reach test The top of a table with a height of 32 cm and a length of 35 cm was scaled by dividing it into cm. The patient was asked to sit on the floor and rest the sole of her bare foot flat on the test table. She was then instructed to reach as far as possible forward on the table without bending her knees from her trunk. The extreme point at which her fingers extended was measured in cm. In this way, at the farthest point, they waited 1-2 seconds without stretching forward or backward. The test was repeated twice, and the mean was recorded in cm
Measured: Baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2025
- Study start4 Jun 2018
- Primary completion10 May 2019
- Study completion10 May 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lumbar Disc HerniationStudies of the same condition, open and under way.
- More trials run by Aydin Adnan Menderes UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two-arm, parallel-group randomized controlled trial. Control group received a conventional physiotherapy program; intervention group received the same program plus neurodynamic mobilization. Treatments were delivered over 4 consecutive weeks. Outcomes included pain, ROM, neurodynamic mobility, functional status and disability.
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Aydin Adnan Menderes University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gurkan Gunaydin, Aydin Adnan Menderes University
- Investigators
- Gurkan Gunaydin, Principal investigator, Aydin Adnan Menderes University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07203560
- Sponsor's protocol ID
- ADU-FTR-GG-01
- Status last verified
- Sep 2025
- First submitted
- 17 Sep 2025
- Last updated
- 2 Oct 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurodynamic Mobilization for the Management of Patients With Lumbar Disc Herniation: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT07203560
- Acronym / sponsor ID
- ADU-FTR-GG-01
- Conditions
- Lumbar Disc Herniation, Low Back Pain
- Keywords
- low back pain, sciatica, Disability Evaluation, Musculoskeletal Manipulations
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Aydin Adnan Menderes UniversityUniversity, hospital or other
- Study start
- 4 Jun 2018 (actual)
- Primary completion
- 10 May 2019 (actual)
- Study completion
- 10 May 2019 (actual)
- First posted
- 2 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this randomized controlled trial was to investigate the effects of neurodynamic mobilization on pain intensity, normal joint motion, neurodynamics, functional level, and disability in patients with lumbar disc herniation.
Detailed description
Background: Low back pain is a major cause of disability worldwide, and due to the limited effectiveness of current treatments, this study aimed to evaluate the efficacy of neurodynamic mobilization technique on pain intensity, range of motion, neurodynamics, functional status, and disability in patients.
Methods: Thirty-seven patients were randomized to control or mobilization group. Participants in the control group received a conventional therapy for 20 treatment sessions, and those in the mobilization group were treated neurodynamic mobilization in addition to the electro/thermal therapy program twice a week for 4 consecutive weeks. Pain level at rest and during activity was recorded with a Visual Analog Scale. Active lumbar flexion, extension, and lateral flexion were measured with a universal goniometer. Neurodynamic mobility was evaluated using neurodynamic tests. The functional status was assessed with the 30-second chair stand test and disability was evaluated with the Bournemouth Questionnaire. 2x2 repeated measures ANOVA models were used to determine within and between group differences.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Two-arm, parallel-group randomized controlled trial. Control group received a conventional physiotherapy program; intervention group received the same program plus neurodynamic mobilization. Treatments were delivered over 4 consecutive weeks. Outcomes included pain, ROM, neurodynamic mobility, functional status and disability.
| Arm | Type | Receives |
|---|---|---|
| Neurodynamic Mobilization + Conventional Therapy (Experimental Group) | Experimental | Other: Neurodynamic Mobilization, Other: Conventional PhysiotherapyParticipants received the conventional physiotherapy program plus neurodynamic mobilization administered by a physical therapist. Treatment was given 5 days a week for 4 weeks, for a total of 20 sessions. |
| Conventional Therapy (Control Group) | Active comparator | Other: Conventional PhysiotherapyIndividuals in control group received hot therapy (Hotpack, 20 minutes), Conventional Tens (60 Hz, 60 msec, 20 minutes) and Therapeutic Ultrasound (1.5 w/cm2, 10 minutes). Patients were given an exercise program to do at home and the treatment was given 5 days a week for 4 weeks, for a total of 20 sessions, to all patients in the study. |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Age between 20 and 60 years
- Diagnosed with lumbar disc herniation at one or more of the L3-L4, L4-L5
- L5-S1 levels with prolapsed, protruding, or extruding disc confirmed by MRI
- Presence of low back pain for at least 6 weeks.
Key exclusion criteria (6 listed)
- Spinal stenosis
- Previous lumbar surgery or medical treatment for disc herniation
- Pregnancy
- Severe osteoporosis
- Diabetes mellitus
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neurodynamic MobilizationIn the experimental group, neurodynamic mobilization was applied in addition to the conventional physiotherapy program. For the neurodynamic mobilization tibial nerve neural mobilization was performed. For neural mobilization of the tibial nerve, the patient was placed in the side-lying position with the hip in 90° flexion, knee flexion and ankle dorsi flexion. In this position, the ankle and hip positions were maintained, and knee extension was performed. When the symptoms were at a level that would not disturb the patient, it was held for 5 seconds, and knee flexion was performed by plantar flexion of the ankle. This practice was performed twice a week with 10 repetitions by a physiotherapist. The same neurodynamic mobilization exercise was recommended to the patients in the neuromobilization group as a home program with 10 repetitions twice a day. | Other | Neurodynamic Mobilization + Conventional Therapy (Experimental Group) |
| Conventional PhysiotherapyAll participants received hot pack therapy (20 minutes), conventional TENS (60 Hz, 60 msec, 20 minutes), therapeutic ultrasound (1.5 W/cm², 10 minutes), and a prescribed home exercise program, delivered 5 days per week for 4 weeks (20 sessions in total). | Other | Conventional Therapy (Control Group), Neurodynamic Mobilization + Conventional Therapy (Experimental Group) |
Primary outcome
Pain Intensity
Time frame: Pain was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)
Patients' rest and activity pain levels was assessed via a visual analog scale (VAS). Participants were asked to mark the intensity of pain they felt on a 10-centimeter (cm) horizontal line (0 indicates no pain, 10 indicates intolerable pain). The point marked on the line was measured with a ruler and the VAS value was recorded in cm
3 secondary outcomes
ROM
Time frame: Rom was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).
Neurodynamic Mobility - Slump Test
Time frame: These were assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).
Neurodynamic Mobility - Sit and Reach Test
Time frame: Baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gurkan Gunaydin principal investigator
Aydin Adnan Menderes University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neurodynamic Mobilization and Conventional Physiotherapy in people with Lumbar Disc Herniation and Low Back Pain, run by Aydin Adnan Menderes University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Intensity (time frame: Pain was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2025.