BPPVNCT07267988
Additional Effects Of Brandt-Daroff Exercises With GANS Maneuver On Dizziness And Quality Of Life In Patients With BPPV
A study testing GANS Maneuver with Brandt-Daroff Exercises and Gans Maneuver in people with BPPV and Dizziness, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of recurrent vertigo, with a lifetime prevalence of about 2.4% and a yearly incidence of roughly 0.6%. It results from displaced otoconia within the semicircular canals and is especially common in older adults. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- BPPV, Dizziness, Quality of Life
- What is being tested?
- GANS Maneuver with Brandt-Daroff Exercises and Gans Maneuver
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 13 Sep 2024to 10 Jan 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed Patients of Benign Paroxysmal Vertigo (BPPV)
- Age between 18-60
- Acute and Chronic BPPV Patients
- Positive Dix-Hallpike Test
- DHI Scale: Mild-Severe (0-100)
Who cannot join
- Patients with a history of vestibular surgery or cochlear
- Patients with a history of seizures or epilepsy
- Patients with a pacemaker or implantable cardioverter-defibrillator (ICD)
- Patients with a history of severe head injury or concussion within the past year
- No other vestibular disorders or conditions that may affect balance (e.g., Meniere's disease, labyrinthitis
- No musculoskeletal or neurological conditions that may affect balance (e.g., stroke, Parkinson's disease)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physical Therapy
Islamabad, 44000
Furqan Ahmed Siddiqi, Phd, 051 5788582 ext. 602, principal.fucp@fui.edu.pk
About this study
Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of recurrent vertigo, with a lifetime prevalence of about 2.4% and a yearly incidence of roughly 0.6%. It results from displaced otoconia within the semicircular canals and is especially common in older adults. BPPV leads to brief, position-provoked episodes of vertigo, dizziness, and imbalance, and reduced quality of life. Although canalith-repositioning maneuvers are highly effective, recurrence is common, emphasizing the need for supportive and adjunctive management strategies.This randomized controlled trial will evaluate the Additional Effects OF Brandt-Daroff Exercise With GANS Maneuver On dizziness And Quality of Life In Patients with BPPV. Thirty patients with BPPV will be recruited at Fauji Foundation Hospital and screened using the Dizziness Handicap Inverntory Scale(DHI) and Vestibular Activities and Participation measure(VAP). Participants will be randomized into two groups: (1) Reciving GANS Manuever Alone (2) GANS Manuever with Brandt-Daroff Exercises(3 sessions per week/40minutes). Dizziness will be assessed using the Dizziness Handicap Inverntory Scale(DHI) , quality of life using the Activities and Participation Measure(VAP) Scale. Outcome measures will be recorded at baseline and post-intervention. Ethical approval will be obtained from FUMC ERC, and data will be analyzed using SPSS v.22.
Read the detailed description
Benign Paroxysmal Positional Vertigo (BPPV) is a common and disabling vestibular disorder, affecting approximately 2.4% of individuals during their lifetime and accounting for nearly 20-30% of vertigo cases in clinical settings. It is caused by the displacement of otoconia into the semicircular canals, leading to brief episodes of vertigo and dizziness, that significantly disrupt daily activities and reduce quality of life. The high prevalence of BPPV is associated with increased risks of falls, functional limitations, and recurrent episodes. Although canalith repositioning maneuvers serve as the primary treatment, recurrence rates remain substantial, underscoring the need for adjunctive therapeutic approaches that address persistent vertigo and improve overall functional outcomes.This study aims to investigate the additional effects GANS maneuver and Brandt-Daroff exercise on dizziness reduction, and quality of life improvement, in BPPV Patients .A randomized controlled trial will be conducted with participants diagnosed with BPPV.This study will be a non blinded, randomized controlled trial with two groups: the intervention group, which will receive GANS Maneuver with Brandt-Daroff Exercises, and the control group, which will receive GANS Maneuver alone. The intervention will last for six weeks, with participants attending two 40-minute sessions per week. A total of 30 individuals with BPPV will be recruited and randomly assigned to one of the two groups. The Dizziness Handicap Inventory Scale(DHI) will be used to screen for dizziness. Quality of life will be measured using the Vestibular and Participation Scale(VAP).The study will be conducted over a period of 1 year at Fauji Foundation Hospital. Ethical approval will be obtained from FUMC ERC. Recruited participants will be allocated to either group through a random sampling method. Outcome measurements will be taken at baseline and again after the 6-week intervention period. Individuals meeting the inclusion criteria will be selected, and written informed consent will be obtained after explaining the study's purpose. Data will be entered and analyzed on SPSS v. 22.
- Conditions
- BPPV, Dizziness, Quality of Life
- Being tested
- GANS Maneuver with Brandt-Daroff Exercises, Gans Maneuver
- Keywords
- Dizziness, BPPV, Postural pain, Quality of life
- Medical subject headings
- Dizziness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
GANS Maneuver with Brandt-Daroff ExercisesProcedure or surgery
The intervention program spans six weeks and involves both supervised Gans Maneuver sessions and home-based Brandt-Daroff exercises. Participants will attend two supervised Gans sessions per week, with each session consisting of three repetitions of the maneuver.
In addition, participants will perform Brandt-Daroff exercises at home twice daily, with each cycle consisting of three repetitions. This combination of supervised and home-based practice will be maintained consistently throughout all six weeks. Across the entire program, participants will complete a total of 12 supervised Gans sessions and 36 Brandt-Daroff home sessions.
Gans ManeuverProcedure or surgery
The control group will participate in a structured six-week intervention program consisting exclusively of the Gans Maneuver. Participants will attend two supervised sessions per week, ensuring consistent oversight and proper technique throughout the program. Each session will include three repetitions of the maneuver, with participants allowed a rest period of 30 to 60 seconds between repetitions to prevent fatigue and maintain the quality of each movement. This frequency and volume are maintained consistently across all six weeks to provide a standardized exposure, allowing for accurate comparison with other intervention groups. Over the entire six-week period, participants will complete a total of 12 supervised sessions, each with three repetitions, summing up to 36 repetitions across the intervention.
| Study group | Role | What they receive |
|---|---|---|
| GANS Maneuver with Brand-Daroff Exercises | Experimental | GANS Maneuver include:
1. Sit upright on a bed with legs extended.
2. Turn patient head 45° toward the affected ear.
3. Quickly lie back so patient head is slightly hanging over the edge
4. Hold this position 30-60 seconds or until vertigo stops.
5. Without lifting the head, rotate it 90° toward the opposite side (45° past midline).
6. Hold again for 30-60 seconds.
7. Continue turning patient head in the same direction and roll onto side so nose faces the floor.
8. Hold 30-60 seconds.
9. Sit up slowly, keeping patient chin slightly tucked.
10. Rest in sitting for about a minute. (3 reps/2 times per week) BRANDTDAROFF EXERCISES Sit upright on the edge of your bed. Turn your head 45° to the left. Keeping the head turned, quickly lie down on your right side. Hold this position 30 seconds or until vertigo stops. Return to sitting; hold 30 seconds. Turn your head 45° to the right. Quickly lie down on your left side. Hold 30 seconds or until vertigo stops. Return to sitting; hold 30 seconds. Receives: Procedure: GANS Maneuver with Brandt-Daroff Exercises |
| GANS Maneuver | Active comparator | GANS Maneuver include:
1. Sit upright on a bed with legs extended.
2. Turn patient head 45° toward the affected ear.
3. Quickly lie back so patient head is slightly hanging over the edge
4. Hold this position 30-60 seconds or until vertigo stops.
5. Without lifting the head, rotate it 90° toward the opposite side (45° past midline).
6. Hold again for 30-60 seconds.
7. Continue turning patient head in the same direction and roll onto side so nose faces the floor.
8. Hold 30-60 seconds.
9. Sit up slowly, keeping patient chin slightly tucked.
10. Rest in sitting for about a minute. (3 reps/2 times per week) Receives: Procedure: Gans Maneuver |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dizziness
Dizziness Handicap Inventory Scale(DHI): 25 Items (scoring16-54) where 16-34 = Mild handicap , 36-52 = moderate handicap , 52+ = severe handicap
Measured: 6 weeks
Quality Of Life In BPPV patients
Vestibular Activities and Participation Scale (VAP): A 34-item, (1-4 score) , 1 = mild limitations, 2 = moderate limitation, and 3 = severe limitations, 4=extreme limitation
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Dec 2025
- Study start13 Sep 2024
- Primary completion10 Dec 2025 (estimated)
- Study completion10 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for BPPVStudies of the same condition, open and under way.
- More trials run by Foundation University IslamabadThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07267988
- Sponsor's protocol ID
- FUI/CTR/2025/12
- Status last verified
- Nov 2025
- First submitted
- 25 Nov 2025
- Last updated
- 5 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Additional Effects Of Brandt-Daroff Exercises With GANS Maneuver On Dizziness And Quality Of Life In Patients With BPPV
- ClinicalTrials.gov ID
- NCT07267988
- Acronym / sponsor ID
- FUI/CTR/2025/12
- Conditions
- BPPV, Dizziness, Quality of Life
- Keywords
- Dizziness, BPPV, Postural pain, Quality of life
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Foundation University IslamabadUniversity, hospital or other
- Study start
- 13 Sep 2024 (actual)
- Primary completion
- 10 Dec 2025 (estimated)
- Study completion
- 10 Jan 2026 (estimated)
- First posted
- 5 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of recurrent vertigo, with a lifetime prevalence of about 2.4% and a yearly incidence of roughly 0.6%. It results from displaced otoconia within the semicircular canals and is especially common in older adults. BPPV leads to brief, position-provoked episodes of vertigo, dizziness, and imbalance, and reduced quality of life. Although canalith-repositioning maneuvers are highly effective, recurrence is common, emphasizing the need for supportive and adjunctive management strategies.This randomized controlled trial will evaluate the Additional Effects OF Brandt-Daroff Exercise With GANS Maneuver On dizziness And Quality of Life In Patients with BPPV. Thirty patients with BPPV will be recruited at Fauji Foundation Hospital and screened using the Dizziness Handicap Inverntory Scale(DHI) and Vestibular Activities and Participation measure(VAP). Participants will be randomized into two groups: (1) Reciving GANS Manuever Alone (2) GANS Manuever with Brandt-Daroff Exercises(3 sessions per week/40minutes). Dizziness will be assessed using the Dizziness Handicap Inverntory Scale(DHI) , quality of life using the Activities and Participation Measure(VAP) Scale. Outcome measures will be recorded at baseline and post-intervention. Ethical approval will be obtained from FUMC ERC, and data will be analyzed using SPSS v.22.
Detailed description
Benign Paroxysmal Positional Vertigo (BPPV) is a common and disabling vestibular disorder, affecting approximately 2.4% of individuals during their lifetime and accounting for nearly 20-30% of vertigo cases in clinical settings. It is caused by the displacement of otoconia into the semicircular canals, leading to brief episodes of vertigo and dizziness, that significantly disrupt daily activities and reduce quality of life. The high prevalence of BPPV is associated with increased risks of falls, functional limitations, and recurrent episodes. Although canalith repositioning maneuvers serve as the primary treatment, recurrence rates remain substantial, underscoring the need for adjunctive therapeutic approaches that address persistent vertigo and improve overall functional outcomes.This study aims to investigate the additional effects GANS maneuver and Brandt-Daroff exercise on dizziness reduction, and quality of life improvement, in BPPV Patients .A randomized controlled trial will be conducted with participants diagnosed with BPPV.This study will be a non blinded, randomized controlled trial with two groups: the intervention group, which will receive GANS Maneuver with Brandt-Daroff Exercises, and the control group, which will receive GANS Maneuver alone. The intervention will last for six weeks, with participants attending two 40-minute sessions per week. A total of 30 individuals with BPPV will be recruited and randomly assigned to one of the two groups. The Dizziness Handicap Inventory Scale(DHI) will be used to screen for dizziness. Quality of life will be measured using the Vestibular and Participation Scale(VAP).The study will be conducted over a period of 1 year at Fauji Foundation Hospital. Ethical approval will be obtained from FUMC ERC. Recruited participants will be allocated to either group through a random sampling method. Outcome measurements will be taken at baseline and again after the 6-week intervention period. Individuals meeting the inclusion criteria will be selected, and written informed consent will be obtained after explaining the study's purpose. Data will be entered and analyzed on SPSS v. 22.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| GANS Maneuver with Brand-Daroff Exercises | Experimental | Procedure: GANS Maneuver with Brandt-Daroff ExercisesGANS Maneuver include: 1. Sit upright on a bed with legs extended. 2. Turn patient head 45° toward the affected ear. 3. Quickly lie back so patient head is slightly hanging over the edge 4. Hold this position 30-60 seconds or until vertigo stops. 5. Without lifting the head, rotate it 90° toward the opposite side (45° past midline). 6. Hold again for 30-60 seconds. 7. Continue turning patient head in the same direction and roll onto side so nose faces the floor. 8. Hold 30-60 seconds. 9. Sit up slowly, keeping patient chin slightly tucked. 10. Rest in sitting for about a minute. (3 reps/2 times per week) BRANDTDAROFF EXERCISES Sit upright on the edge of your bed. Turn your head 45° to the left. Keeping the head turned, quickly lie down on your right side. Hold this position 30 seconds or until vertigo stops. Return to sitting; hold 30 seconds. Turn your head 45° to the right. Quickly lie down on your left side. Hold 30 seconds or until vertigo stops. Return to sitting; hold 30 seconds. |
| GANS Maneuver | Active comparator | Procedure: Gans ManeuverGANS Maneuver include: 1. Sit upright on a bed with legs extended. 2. Turn patient head 45° toward the affected ear. 3. Quickly lie back so patient head is slightly hanging over the edge 4. Hold this position 30-60 seconds or until vertigo stops. 5. Without lifting the head, rotate it 90° toward the opposite side (45° past midline). 6. Hold again for 30-60 seconds. 7. Continue turning patient head in the same direction and roll onto side so nose faces the floor. 8. Hold 30-60 seconds. 9. Sit up slowly, keeping patient chin slightly tucked. 10. Rest in sitting for about a minute. (3 reps/2 times per week) |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Diagnosed Patients of Benign Paroxysmal Vertigo (BPPV)
- Age between 18-60
- Acute and Chronic BPPV Patients
- Positive Dix-Hallpike Test
- DHI Scale: Mild-Severe (0-100)
Key exclusion criteria (6 listed)
- Patients with a history of vestibular surgery or cochlear
- Patients with a history of seizures or epilepsy
- Patients with a pacemaker or implantable cardioverter-defibrillator (ICD)
- Patients with a history of severe head injury or concussion within the past year
- No other vestibular disorders or conditions that may affect balance (e.g., Meniere's disease, labyrinthitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| GANS Maneuver with Brandt-Daroff ExercisesThe intervention program spans six weeks and involves both supervised Gans Maneuver sessions and home-based Brandt-Daroff exercises. Participants will attend two supervised Gans sessions per week, with each session consisting of three repetitions of the maneuver. In addition, participants will perform Brandt-Daroff exercises at home twice daily, with each cycle consisting of three repetitions. This combination of supervised and home-based practice will be maintained consistently throughout all six weeks. Across the entire program, participants will complete a total of 12 supervised Gans sessions and 36 Brandt-Daroff home sessions. | Procedure or surgery | GANS Maneuver with Brand-Daroff Exercises |
| Gans ManeuverThe control group will participate in a structured six-week intervention program consisting exclusively of the Gans Maneuver. Participants will attend two supervised sessions per week, ensuring consistent oversight and proper technique throughout the program. Each session will include three repetitions of the maneuver, with participants allowed a rest period of 30 to 60 seconds between repetitions to prevent fatigue and maintain the quality of each movement. This frequency and volume are maintained consistently across all six weeks to provide a standardized exposure, allowing for accurate comparison with other intervention groups. Over the entire six-week period, participants will complete a total of 12 supervised sessions, each with three repetitions, summing up to 36 repetitions across the intervention. | Procedure or surgery | GANS Maneuver |
Primary outcome
Dizziness
Time frame: 6 weeks
Dizziness Handicap Inventory Scale(DHI): 25 Items (scoring16-54) where 16-34 = Mild handicap , 36-52 = moderate handicap , 52+ = severe handicap
Quality Of Life In BPPV patients
Time frame: 6 weeks
Vestibular Activities and Participation Scale (VAP): A 34-item, (1-4 score) , 1 = mild limitations, 2 = moderate limitation, and 3 = severe limitations, 4=extreme limitation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing GANS Maneuver with Brandt-Daroff Exercises and Gans Maneuver in people with BPPV and Dizziness, run by Foundation University Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rabia Ejaz, DPT (+92 3145281989, rabiaejaz57@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dizziness (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Dec 2025.