Clinical trials: Cardiogenic Shock
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Heart Failure, Muscle Atrophy
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist…
- Conditions
- Heart Failure, Muscle Atrophy, Skeletal Muscle Atrophy, Cardiogenic Shock
- Trial name
- NCT06253104
- Testing
- BodyMetrix Body Composition Ultrasound
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tufts Medical Center
Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall
Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support
A prospective, multi-center, open label, randomized controlled, superiority trial to compare clinical outcomes between routine distal perfusion catheter (DPC) insertion versus provisional distal perfusion catheter (DPC) insertion…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall, Congestive Heart Failure, Myocarditis
- Trial name
- PERFUSE-MCS (NCT07482865)
- Testing
- Distal perfusion catheter insertion
- Where
- 6 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Cardiogenic Shock, Euthyroid Sick Syndrome
Factors Influencing Outcomes in ECMO and Impella Patients: Metabolic and Thyroid Hormone Dynamics
This prospective, single-center, consecutive observational study evaluates clinical, metabolic, and endocrine factors influencing survival and clinical outcomes in adult patients undergoing temporary mechanical circulatory…
- Conditions
- Cardiogenic Shock, Euthyroid Sick Syndrome, Critical Illness
- Trial name
- NCT07885618
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Cardiogenic Shock
Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock
The goal of this multicenter, open-label, randomized clinical trial is to learn whether norepinephrine or dopamine is more effective and safer as the first-line vasoactive drug for treating cardiogenic shock in adults.
- Trial name
- ACTION-CS (NCT07562932)
- Testing
- Norepinephrine, Dopamine Agent
- Where
- South Korea
- Volunteers
- 512 people
- Sponsor
- Chonnam National University Hospital
VA-ECMO for Postcardiotomy Cardiogenic Shock
Timing of VA-ECMO Support During or After Cardiac Surgery
Some patients develop severe heart failure during or after cardiac surgery and require temporary support for circulation and oxygenation.
- Trial name
- NCT07873034
- Where
- Slovakia
- Volunteers
- 128 people
- Sponsor
- National Institute of Cardiovascular Diseases, Slovakia
Heart Failure, Cardiogenic Shock
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in patients with decompensated heart failure and cardiogenic shock.
- Conditions
- Heart Failure, Cardiogenic Shock, Reduced Ejection Fraction Heart Failure
- Trial name
- INTeGRATE (NCT06965504)
- Testing
- Impella 5.5 SmartAssist
- Where
- 17 sites in United States
- Volunteers
- 250 people
- Sponsor
- Abiomed Inc.
Cardiogenic Shock
French Observatory on the Management of Cardiogenic Shock 2
The aim of this observational study is to describe the baseline characteristics, management strategies, and early outcomes (during hospitalisation and at 30 days) of patients admitted to intensive care with cardiogenic shock…
- Trial name
- FRENSHOCK 2 (NCT07868757)
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- French Cardiology Society
Cardiogenic Shock
Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock
Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to organ hypoperfusion and high mortality.
- Trial name
- CARDIOPAM (NCT07345559)
- Testing
- Personalized MAP, Standard MAP
- Where
- 11 sites in France
- Volunteers
- 406 people
- Sponsor
- CMC Ambroise Paré
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiogenic Shock
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
The goal of this clinical trial is to learn if the drug istaroxime works to treat cardiogenic shock due to acute heart failure in adults. It will also learn about the safety of istaroxime.
- Trial name
- RESCUE HF-CS (NCT07583446)
- Testing
- istaroxime
- Where
- Armenia
- Volunteers
- 600 people
- Sponsor
- Seismic Pharmaceuticals Operations LLC
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Cardiogenic Shock, Acute Myocardial Infarction
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock
This is a prospective, single-center, observational pilot study of the investigational NIRSense Tissue Oximetry Sensor System (Envello Core), a noninvasive wearable sensor patch that uses near-infrared spectroscopy (NIRS) and…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Acute Decompensated Heart Failure
- Trial name
- NCT07825363
- Testing
- NIRSense Tissue Oximetry Sensor System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NIRSense Inc.
Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction
Hong Kong Cardiogenic Shock Initiative
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is a severe condition with high mortality. Early revascularization and Impella device (Abiomed) support improve outcomes.
- Conditions
- Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction, Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- HK CSI (NCT07323238)
- Where
- Hong Kong
- Volunteers
- 320 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Shock, Cardiogenic
A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care.
The objective of this Phase 1b/2a trial is to evaluate the safety, tolerability, and exploratory efficacy of invobenitug (also known as procizumab), a monoclonal antibody under development for the treatment of cardiogenic shock…
- Trial name
- PROCARD 2a (NCT06832722)
- Testing
- AK1967 (Invobenitug also known as Procizumab)
- Where
- 37 sites in Armenia, Belgium and 7 more
- Volunteers
- 90 people
- Sponsor
- 4TEEN4 Pharmaceuticals GmbH
Myocardial Infarction (MI), Cardiogenic Shock
Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock
PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI.
- Conditions
- Myocardial Infarction (MI), Cardiogenic Shock, ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- PRIME-SHOCK (NCT07817472)
- Testing
- Routine pre-PCI Impella CP, Selective post-PCI Impella CP
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Chonnam National University Hospital
Cardiogenic Shock
Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA)
This is a prospective and retrospective multicentre study conducted under the scientific coordination of the IRCCS Fondazione Don Gnocchi and funded by the Italian Ministry of Health (PNRR-MCNT2-2023-12377767).
- Trial name
- ENIGMA (NCT06572826)
- Testing
- Cardiac Rehabilitation intervention
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiogenic Shock
Catheter-Oriented Unloading and Recovery With a Left Ventricular Assist Gear: Efficacy in Post Cardiotomy Cardiogenic Shock
This study is a prospective, multicenter, single-arm clinical trial conducted in China to evaluate the efficacy and safety of a novel left ventricular assist device, SynFlow Duro system, manufactured by ForQaly Medical in the…
- Trial name
- COURAGE (NCT07560085)
- Testing
- SynFlow Duro
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ForQaly Medical (Shanghai) Co., Ltd