Respiratory Muscle TrainingNCT07637331
The Effect of Respiratory Muscle Training on Cognitive Performance
A study testing Inspiratory muscle training in people with Respiratory Muscle Training, run by Indiana University at 1 site in United States.
Trial summary
Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Respiratory Muscle Training
- What is being tested?
- Inspiratory muscle training
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 32 participants
- Where
- 1 siteUnited States
- Study dates
- 27 Mar 2026to Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18-40 years old
- Body mass index <30 kg/m2
- Naïve to IMT
- >75% of predicted forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) (FEV1/FVC)
- Access to smart phone or tablet with internet
Who cannot join
- Diagnosed:
- Cardiovascular disease
- Respiratory disease (including asthma)
- Metabolic disease
- Currently pregnant
- Unable to adhere to the IMT protocol
Show all 10Show fewer
- Answering 'yes' to any of the questions on page one of the PAR-Q+
- Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)
- Self-reported color blindness
- Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Indiana University
Bloomington, Indiana, 47405
Blair Johnson, PhD, 812-855-8699, bj33@iu.edu
Blair Johnson, PhD
About this study
Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.
- Conditions
- Respiratory Muscle Training
- Being tested
- Inspiratory muscle training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Inspiratory muscle trainingDevice
8 weeks of active or sham inspiratory muscle training
| Study group | Role | What they receive |
|---|---|---|
| Active IMT | Experimental | Inspiratory muscle training Receives: Device: Inspiratory muscle training |
| Sham IMT | Sham comparator | Sham inspiratory muscle training Receives: Device: Inspiratory muscle training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diaphragm thickness
ultrasound measurements of diaphragm thickness
Measured: Baseline and after 8 weeks of training
Cognitive performance
CAAPES performance with the higher percentage correct corresponding to a better performance.
Measured: Baseline and after 8 weeks of training
Secondary outcomes (1)
Dyspnea
Measure of breathing discomfort and pleasantness using a visual analog scale, the higher the value the more discomfort and unpleasant the subject's breathing is.
Measured: Baseline and after 8 weeks of training
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jun 2026
- Study start27 Mar 2026
- Primary completionApr 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Respiratory Muscle TrainingStudies of the same condition, open and under way.
- More trials run by Indiana UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Indiana University
- Sponsor type
- University, hospital or other
- Collaborators
- United States Air Force Research Laboratory
- Responsible party
- Principal investigator, Blair D. Johnson, PhD, Indiana University
- Investigators
- Blair Johnson, PhD, Principal investigator, Indiana University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07637331
- Sponsor's protocol ID
- 28083
- Status last verified
- Jun 2026
- First submitted
- 1 Jun 2026
- Last updated
- 26 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Respiratory Muscle Training on Cognitive Performance
- ClinicalTrials.gov ID
- NCT07637331
- Acronym / sponsor ID
- 28083
- Conditions
- Respiratory Muscle Training
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- Indiana UniversityUniversity, hospital or other
- Collaborators
- United States Air Force Research Laboratory
- Study start
- 27 Mar 2026 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 9 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Active IMT | Experimental | Device: Inspiratory muscle trainingInspiratory muscle training |
| Sham IMT | Sham comparator | Device: Inspiratory muscle trainingSham inspiratory muscle training |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- 18-40 years old
- Body mass index <30 kg/m2
- Naïve to IMT
- >75% of predicted forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) (FEV1/FVC)
- Access to smart phone or tablet with internet
Key exclusion criteria (10 listed)
- Diagnosed:
- Answering 'yes' to any of the questions on page one of the PAR-Q+
- Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)
- Self-reported color blindness
- Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Inspiratory muscle training8 weeks of active or sham inspiratory muscle training | Device | Active IMT, Sham IMT |
Primary outcome
Diaphragm thickness
Time frame: Baseline and after 8 weeks of training
ultrasound measurements of diaphragm thickness
Cognitive performance
Time frame: Baseline and after 8 weeks of training
CAAPES performance with the higher percentage correct corresponding to a better performance.
1 secondary outcome
Dyspnea
Time frame: Baseline and after 8 weeks of training
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Blair Johnson, PhD principal investigator
Indiana University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Inspiratory muscle training in people with Respiratory Muscle Training, run by Indiana University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Blair Johnson (812-855-8699, bj33@iu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diaphragm thickness (time frame: Baseline and after 8 weeks of training). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jun 2026.