Anterior Cruciate Ligament InjuryNCT07671729
Quadriceps Tendon vs Peroneus Longus Tendon in ACL Reconstruction
A study testing Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft and Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft in people with Anterior Cruciate Ligament Injury and Anterior Cruciate Ligament Rupture, run by Acibadem University at 1 site in Turkey (Türkiye).
Trial summary
This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- What is being tested?
- Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft and Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 May 2026to Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients diagnosed with anterior cruciate ligament rupture
- Patients scheduled for primary anterior cruciate ligament reconstruction
- Age between 18 and 50 years
- Ability to provide informed consent
- Willingness to comply with postoperative rehabilitation and follow-up evaluations
Who cannot join
- Previous ligament reconstruction surgery on the affected knee
- Multi-ligament knee injuries requiring additional ligament reconstruction
- Severe osteoarthritis of the knee
- Revision anterior cruciate ligament reconstruction
- Neuromuscular disorders affecting lower extremity function
- Active infection
- Inability to comply with follow-up protocol
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Acibadem Fulya Hospital, Sport Medicine Center
Istanbul, Besiktas, 34349
Tunay Erden, M.D., +905546289045, tunayerden@gmail.com
About this study
Official title: A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes
This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Clinical examination findings, return-to-sport outcomes, ankle muscle strength, ankle-related functional scores, and gait analysis parameters will be evaluated at 6 months and 12 months postoperatively. The study aims to investigate both knee-related functional outcomes and donor site morbidity associated with graft harvesting techniques.
Read the detailed description
Anterior cruciate ligament (ACL) reconstruction is one of the most commonly performed orthopedic procedures for restoring knee stability and enabling return to sports activities after ACL injury. Various autograft options have been described for ACL reconstruction, including hamstring tendon, bone-patellar tendon-bone, quadriceps tendon, and more recently, peroneus longus tendon grafts. Each graft option has unique biomechanical characteristics, advantages, and potential donor site morbidities.
Quadriceps tendon autografts have gained increasing popularity because of their adequate graft diameter, favorable biomechanical properties, and relatively low donor site complications. Peroneus longus tendon autografts have also emerged as a promising alternative graft source with satisfactory clinical outcomes and sufficient graft size. However, concerns remain regarding donor site morbidity, particularly potential effects on ankle muscle strength and ankle function following peroneus longus tendon harvesting.
This prospective randomized study aims to compare quadriceps tendon and peroneus longus tendon autografts in patients undergoing primary ACL reconstruction. Patients will be randomly assigned into two groups according to graft type. Clinical evaluations, functional knee scores, return-to-sport outcomes, ankle muscle strength assessments, ankle-related functional scores, and gait analysis parameters will be assessed during postoperative follow-up.
Follow-up evaluations will be performed at 6 months and 12 months after surgery. The findings of this study are expected to contribute to graft selection strategies in ACL reconstruction by providing comparative data regarding clinical outcomes, functional recovery, gait characteristics, and donor site morbidity.
- Being tested
- Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft, Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft
- Keywords
- ACL reconstruction, Anterior cruciate ligament, Quadriceps tendon autograft, Peroneus longus tendon autograft, Gait analysis, Return to sport, Knee stability, Ankle muscle strength, Functional outcomes, Randomized controlled trial
- Medical subject headings
- Anterior Cruciate Ligament Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon AutograftProcedure or surgery
Anterior cruciate ligament reconstruction performed using quadriceps tendon autograft.
Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon AutograftProcedure or surgery
Anterior cruciate ligament reconstruction performed using peroneus longus tendon autograft.
| Study group | Role | What they receive |
|---|---|---|
| Quadriceps Tendon Autograft | Experimental | Patients undergoing anterior cruciate ligament reconstruction using quadriceps tendon autograft. Receives: Procedure: Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft |
| Peroneus Longus Tendon Autograft | Experimental | Patients undergoing anterior cruciate ligament reconstruction using peroneus longus tendon autograft. Receives: Procedure: Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft |
What is being measured
The primary outcome is the main question the study is designed to answer.
International Knee Documentation Committee (IKDC) Subjective Knee Score
Comparison of postoperative subjective knee function between quadriceps tendon and peroneus longus tendon autograft groups using the International Knee Documentation Committee (IKDC) subjective knee evaluation form.
Measured: 12 months postoperatively
Secondary outcomes (9)
Return to Sport Rate
6 and 12 months postoperatively
Measured: Assessment of return to pre-injury level of sports activity following anterior cruciate ligament reconstruction.
Ankle Plantar Flexion Strength
Isokinetic ankle plantar flexion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during plantar flexion will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Ankle Dorsiflexion Strength
Isokinetic ankle dorsiflexion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during dorsiflexion will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Ankle Inversion Strength
Isokinetic ankle inversion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during inversion will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Ankle Eversion Strength
Isokinetic ankle eversion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during eversion will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Ankle Rotational Strength
Isokinetic ankle rotational strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during rotational movements will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Ground Reaction Force
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Ground reaction force (N) during standardized standing and functional testing tasks will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Force Asymmetry
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Force asymmetry (%) during standardized standing and functional testing tasks will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Weight Distribution
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Weight distribution (%) during standardized standing and functional testing tasks will be recorded and compared between study groups.
Measured: 6 and 12 months postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2026
- Study start1 May 2026
- Primary completionMay 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Cruciate Ligament InjuryStudies of the same condition, open and under way.
- More trials run by Acibadem UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to undergo anterior cruciate ligament reconstruction using either quadriceps tendon autograft or peroneus longus tendon autograft in parallel groups.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Acibadem University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muzaffer Agir, Acibadem University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07671729
- Sponsor's protocol ID
- Quadriceps vs PL
- Status last verified
- Apr 2026
- First submitted
- 12 Jun 2026
- Last updated
- 26 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 26 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes
- ClinicalTrials.gov ID
- NCT07671729
- Acronym / sponsor ID
- Quadriceps vs PL
- Keywords
- ACL reconstruction, Anterior cruciate ligament, Quadriceps tendon autograft, Peroneus longus tendon autograft, Gait analysis, Return to sport, Knee stability, Ankle muscle strength
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Acibadem UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (actual)
- Primary completion
- May 2027 (estimated)
- Study completion
- Dec 2027 (estimated)
- First posted
- 26 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Clinical examination findings, return-to-sport outcomes, ankle muscle strength, ankle-related functional scores, and gait analysis parameters will be evaluated at 6 months and 12 months postoperatively. The study aims to investigate both knee-related functional outcomes and donor site morbidity associated with graft harvesting techniques.
Detailed description
Anterior cruciate ligament (ACL) reconstruction is one of the most commonly performed orthopedic procedures for restoring knee stability and enabling return to sports activities after ACL injury. Various autograft options have been described for ACL reconstruction, including hamstring tendon, bone-patellar tendon-bone, quadriceps tendon, and more recently, peroneus longus tendon grafts. Each graft option has unique biomechanical characteristics, advantages, and potential donor site morbidities.
Quadriceps tendon autografts have gained increasing popularity because of their adequate graft diameter, favorable biomechanical properties, and relatively low donor site complications. Peroneus longus tendon autografts have also emerged as a promising alternative graft source with satisfactory clinical outcomes and sufficient graft size. However, concerns remain regarding donor site morbidity, particularly potential effects on ankle muscle strength and ankle function following peroneus longus tendon harvesting.
This prospective randomized study aims to compare quadriceps tendon and peroneus longus tendon autografts in patients undergoing primary ACL reconstruction. Patients will be randomly assigned into two groups according to graft type. Clinical evaluations, functional knee scores, return-to-sport outcomes, ankle muscle strength assessments, ankle-related functional scores, and gait analysis parameters will be assessed during postoperative follow-up.
Follow-up evaluations will be performed at 6 months and 12 months after surgery. The findings of this study are expected to contribute to graft selection strategies in ACL reconstruction by providing comparative data regarding clinical outcomes, functional recovery, gait characteristics, and donor site morbidity.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to undergo anterior cruciate ligament reconstruction using either quadriceps tendon autograft or peroneus longus tendon autograft in parallel groups.
| Arm | Type | Receives |
|---|---|---|
| Quadriceps Tendon Autograft | Experimental | Procedure: Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon AutograftPatients undergoing anterior cruciate ligament reconstruction using quadriceps tendon autograft. |
| Peroneus Longus Tendon Autograft | Experimental | Procedure: Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon AutograftPatients undergoing anterior cruciate ligament reconstruction using peroneus longus tendon autograft. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients diagnosed with anterior cruciate ligament rupture
- Patients scheduled for primary anterior cruciate ligament reconstruction
- Age between 18 and 50 years
- Ability to provide informed consent
- Willingness to comply with postoperative rehabilitation and follow-up evaluations
Key exclusion criteria (7 listed)
- Previous ligament reconstruction surgery on the affected knee
- Multi-ligament knee injuries requiring additional ligament reconstruction
- Severe osteoarthritis of the knee
- Revision anterior cruciate ligament reconstruction
- Neuromuscular disorders affecting lower extremity function
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon AutograftAnterior cruciate ligament reconstruction performed using quadriceps tendon autograft. | Procedure or surgery | Quadriceps Tendon Autograft |
| Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon AutograftAnterior cruciate ligament reconstruction performed using peroneus longus tendon autograft. | Procedure or surgery | Peroneus Longus Tendon Autograft |
Primary outcome
International Knee Documentation Committee (IKDC) Subjective Knee Score
Time frame: 12 months postoperatively
Comparison of postoperative subjective knee function between quadriceps tendon and peroneus longus tendon autograft groups using the International Knee Documentation Committee (IKDC) subjective knee evaluation form.
9 secondary outcomes
Return to Sport Rate
Time frame: Assessment of return to pre-injury level of sports activity following anterior cruciate ligament reconstruction.
Ankle Plantar Flexion Strength
Time frame: 6 and 12 months postoperatively
Ankle Dorsiflexion Strength
Time frame: 6 and 12 months postoperatively
Ankle Inversion Strength
Time frame: 6 and 12 months postoperatively
Ankle Eversion Strength
Time frame: 6 and 12 months postoperatively
Ankle Rotational Strength
Time frame: 6 and 12 months postoperatively
Ground Reaction Force
Time frame: 6 and 12 months postoperatively
Force Asymmetry
Time frame: 6 and 12 months postoperatively
Weight Distribution
Time frame: 6 and 12 months postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jun 2026.
- Individual participant dataSharing planned: Undecided
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Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
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Clinical and Biological Outcomes of BioBrace-Augmented ACL Reconstruction
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Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Acibadem Fulya Hospital, Sport Medicine Center
Istanbul, Turkey (Türkiye)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft and Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft in people with Anterior Cruciate Ligament Injury and Anterior Cruciate Ligament Rupture, run by Acibadem University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
International Knee Documentation Committee (IKDC) Subjective Knee Score (time frame: 12 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jun 2026.