Clinical trials: Anterior Cruciate Ligament Injury
ACL - Anterior Cruciate Ligament Rupture
Microbiological Molecular Profile of the Knee Joint During Primary Reconstruction or Revision Surgery of the ACL
Anterior cruciate ligament (ACL) reconstructions are common surgical procedures, but a significant number fail for reasons that are not fully understood.
- Trial name
- INFECTIOGEN (NCT07009392)
- Testing
- NGS Analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament Injuries
Operant Conditioning After ACL Reconstruction
The purpose of this study is to examine if the changes in corticospinal function that accompany ACL reconstruction can be improved through a form of mental coaching and encouragement, known as operant conditioning.
- Trial name
- NCT05519345
- Testing
- Operant Conditioning, Control
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
ACL Injury, Rehabilitation After ACL Reconstruction
Functional Outcomes of an Accelerated Rehabilitation Protocol for ACL Reconstruction in Amateur Athletes
The main goal of a rehabilitation program after an ACL reconstruction is to regain mobility and muscle function and ultimately to return to sports participation.
- Conditions
- ACL Injury, Rehabilitation After ACL Reconstruction, Accelerated Protocol
- Trial name
- ACL (NCT05716529)
- Testing
- rehabilitation protocol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
ACL Injury, Muscle Weakness
Nordic Hamstring Exercise After ACL Reconstruction Reconstruction
Anterior cruciate ligament (ACL) injuries constitute a significant portion of major knee joint injuries sustained by young, active individuals, and significantly increase risk for long-term disability.
- Conditions
- ACL Injury, Muscle Weakness, Neuromuscular Manifestations
- Trial name
- NCT05738200
- Testing
- Nordic Hamstring Exercise
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Toledo
Anterior Cruciate Ligament Injuries
Graft Selection in Anatomic Anterior Cruciate Ligament Reconstruction
A rupture of the anterior cruciate ligament (ACL) is a severe injury of the knee. The current gold Standard treatment for young and active patients with instability, is a surgical ACL reconstruction.
- Trial name
- Grafttype (NCT03073083)
- Testing
- Hamstring tendon autograft, Pattella tendon autograft, Quadriceps tendon autograft
- Where
- 2 sites in Netherlands
- Volunteers
- 439 people
- Sponsor
- Orthopedisch Centrum Oost Nederland
Scale Reliability Validity, ACL Injury
Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population
Submission of the KOOS ACL questionnaires in Italian for the purpose of validation and cultural adaptation of the KOOS-ACL scale for the Italian population.
- Conditions
- Scale Reliability Validity, ACL Injury, Validation and Cultural Adaptation of a Scale, PROMs
- Trial name
- VACKP (NCT07386405)
- Testing
- PROMS submition
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Meniscus Lesion, Meniscus Disorder
Dynamic Ultrasonography VS MRI in the Evaluation of Meniscal Lesions in Patients With an Indication for Arthroscopy
This is a diagnostic, open-label, single-center interventional study. This study aims to evaluate the diagnostic accuracy of dynamic ultrasonography for meniscal injuries in patients with an indication for arthroscopy, and to…
- Conditions
- Meniscus Lesion, Meniscus Disorder, ACL Injuries
- Trial name
- NCT06159153
- Testing
- Dynamic Ultrasonography assessment
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Valgus
Integrated Training Program On Jump Performance And Knee Valgus In Youth Football Players
This study aimed to investigate the effects of stretching, strength, and plyometric exercise training programs, applied in addition to regular training, on jumping performance and knee valgus values in football players.
- Trial name
- NCT07009041
- Testing
- Strength training program, Stretching exercises program, Plyometric exercises program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Rupture of Anterior Cruciate Ligament, Infiltration
Local Infiltration Analgesia vs Adductor Canal Block for Analgesia After Anterior Cruciate Ligament Reconstruction
Early rehabilitation after anterior cruciate ligament reconstruction is of paramount importance and requires optimal pain control based on a multimodal concept, including injection of local anaesthetics.
- Conditions
- Rupture of Anterior Cruciate Ligament, Infiltration, Regional Anesthesia Morbidity
- Trial name
- NCT02524652
- Testing
- Ropivacaine 0.5% 20 mLs
- Where
- Switzerland
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Injury of Anterior Cruciate Ligament
Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair
Anterior cruciate ligament repair using hamstring autograft in children is a painful orthopedic procedure. The current practice to provide analgesia for this procedure include femoral continuous perineural infusion and femoral…
- Trial name
- NCT02075411
- Testing
- bupivacaine, continuous perineural infusion catheter
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
ACL Injury, ACL Reconstruction
Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction
The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the…
- Conditions
- ACL Injury, ACL Reconstruction, Scar Formation
- Trial name
- NCT07135687
- Testing
- Losartan
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Rush University Medical Center
Anterior Cruciate Ligament Injuries, Injuries, Knee
Effects Provided by a Physiotherapy Treatment Preventing Lower Extremity Injuries in Female Football Players
Background and justification: Women's football has a percentage of knee injury of 31.8%, and the anterior cruciate ligament lesion is between 2 and 4 times higher than the male.
- Conditions
- Anterior Cruciate Ligament Injuries, Injuries, Knee, Prevention & Control
- Trial name
- NCT04062578
- Testing
- Physiotherapy program of lumbopelvic stabilization and strengthening of the hip region musculature
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
ACL Injuries
Plyometric Training With or Without Hamstring Strengthening for Preventing ACL Injuries in Female Amateur Athletes
This randomized controlled trial explored the effect of plyometric training with or without hamstring strengthening in preventing anterior cruciate ligament (ACL) injuries among female amateur athletes aged 18 to 30.
- Trial name
- NCT07047833
- Testing
- Plyometric Training with Hamstring Strengthening, Plyometric Training Only
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee
Post-Traumatic Knee Osteoarthritis Following Anterior Cruciate Ligament Reconstruction
The purpose of this trial is to define knee joint pathomechanics (KJPM) in the first 2 years after ACL reconstruction (ACLR) and relate these KJPM with changes in articular cartilage morphology and quality.
- Trial name
- NCT06201442
- Testing
- Imaging - magnetic resonance imaging (MRI), Blood sampling, Assessment of functionality and strength
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anterior Cruciate Ligament Injuries
Control of the Opening of mPTP by Ex Vivo Measurements on Permeabilized Muscle Fibers (COMMEF)
mPTP (Mitochondrial Permeability Transition Pore) is a channel formed by a protein complex integrated into the inner membrane of mitochondria.
- Trial name
- COMMEF (NCT04209413)
- Testing
- Patients referred for a knee ligamentoplasty
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Injury of Anterior Cruciate Ligament
Sport Cord Test Following ACL Reconstruction
The primary purpose of this study is to determine the interrater reliability and validity of the Sportcord Test as a measure of physical performance following anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT01937403
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- The Hawkins Foundation
Muscle Weakness, Anterior Cruciate Ligament Rupture
Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction?
Anterior cruciate ligament (ACL) injury is a common sport injury in both professional and recreational athletes. Furthermore, persistent quadriceps weakness and wasting are frequently observed after anterior cruciate ligament…
- Trial name
- NCT03496389
- Testing
- Gabapentin, Tramadol, Panadol
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
ACL Injury
TeleRehabilitation Following ACL Reconstruction
Telerehabilitation is a form of tele-treatment in which rehabilitation services are dispensed at patients' home utilizing video telecommunication services with real-time synchronous exchange of information.
- Trial name
- NCT04541940
- Testing
- Telerehabilitation Therapy, In-person Rehabilitation Therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Anterior Cruciate Ligament Rupture
The Effect of Subtalar Joint Antipronation Taping on the Dynamic Knee Valgus in Female Volleyball Players with Low Medial Arch
This study aims to investigate the biomechanical mechanisms of dynamic knee valgus and the impact of subtalar pronation, particularly due to decreased medial longitudinal arch, on knee injury risk, highlighting the importance of…
- Trial name
- NCT06752109
- Testing
- Antipronation Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara Yildirim Beyazıt University
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction Rehabilitation
Eccentric Phase Biomechanics of the Countermovement Jump After Anterior Cruciate Ligament Reconstruction
Purpose: This study aims to better understand how force is produced during a vertical jump in individuals approximately six months after anterior cruciate ligament reconstruction compared with healthy individuals.
- Trial name
- DECAL (NCT07448064)
- Testing
- Countermovement Jump Force Platform Assessment, Isokinetic Test
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Haute Ecole ARC Sante