Clinical trials: Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
ACL - Anterior Cruciate Ligament Rupture
SharkScrew ACL RCT
This prospective, randomized controlled trial will compare three tibial interference screw types used for graft fixation during primary anterior cruciate ligament (ACL) reconstruction: a polyetheretherketone (PEEK) screw, a…
- Trial name
- NCT07830953
- Testing
- ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Austrian Workers Compensation Board Styria
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries
Over-the-Top vs. Anteromedial ACLR With Lateral Extraarticular Tenodesis
This study aims to compare the over-the-top (OTT) anterior cruciate ligament (ACL) reconstruction (ACL-R) technique with the anteromedial ACL-R + lateral extraarticular tenodesis (LET).
- Conditions
- Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
- Trial name
- NCT06664047
- Testing
- OTT ACLR, ACLR LET
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Werewolf Flow 50 During ACL Reconstruction
The aim of this study is to compare the outcomes, ease of use, and cost of the Werewolf FLOW50 device to the institutional standard of care which is does not include the use of electrocautery devices during anterior cruciate…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
- Trial name
- NCT04998656
- Testing
- Werewolf FLOW 50, Control
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear
Active Noise-Cancelling Headphones With Closed-Loop Communication During Arthroscopic ACL Reconstruction
Operating room noise may interfere with communication, concentration, and surgical workflow. Active noise-cancelling (ANC) headphones can reduce background auditory distractions; however, their potential benefit during surgery…
- Conditions
- Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Injury
- Trial name
- ANC-ACL-2026 (NCT07589582)
- Testing
- Active Noise-Cancelling Headphones With Closed-Loop Communication, Standard Operating Room Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anterior Cruciate Ligament Rupture
Initial Graft Tension and ACL Surgery
The anterior cruciate ligament (ACL) is one of four strong ligaments connecting the bones of the knee joint. If overstretched, the ACL can tear. Reconstruction of a torn ACL is now a common surgical procedure.
- Trial name
- NCT00434837
- Testing
- Initial graft tension during ACL reconstruction surgery
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Anterior Cruciate Ligament (ACL) Rupture, Anterior Cruciate Ligament (ACL) Reconstruction
Comparison of Video Based Phone App vs. Supervised Preoperative Exercise for ACL Reconstruction
The goal of this clinical trial is to learn if using a phone app for exercises is as effective as working with a physical therapist before anterior cruciate ligament knee surgery.
- Conditions
- Anterior Cruciate Ligament (ACL) Rupture, Anterior Cruciate Ligament (ACL) Reconstruction, Anterior Cruciate Ligament (ACL) Injury
- Trial name
- ACL-PREHAB-APP (NCT07322497)
- Testing
- Mobile App Exercise Program, Supervised Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Rupture of Anterior Cruciate Ligament
Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
The purpose of this study is to determine the effect of modifiable risk factors on knee function, osteoarthritis, and re-rupture of the anterior cruciate ligament (ACL) following ACL reconstruction.
- Trial name
- NCT00463099
- Where
- 8 sites in United States
- Volunteers
- 3,294 people
- Sponsor
- Vanderbilt University Medical Center
Rupture of Anterior Cruciate Ligament
Multicenter ACL Revision Study (MARS)
The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL)…
- Trial name
- MARS (NCT00625885)
- Where
- 49 sites in United States, Canada
- Volunteers
- 1,234 people
- Sponsor
- Vanderbilt University Medical Center
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
ACL - Anterior Cruciate Ligament Rupture
Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture
The goal of this interventional study is to measure medial vastus inhibition and associate it with AMI classification in patients with ACL rupture.
- Trial name
- AMIVAL (NCT06945133)
- Testing
- Clinical testing
- Where
- France
- Volunteers
- 90 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL - Anterior Cruciate Ligament Rupture
Microbiological Molecular Profile of the Knee Joint During Primary Reconstruction or Revision Surgery of the ACL
Anterior cruciate ligament (ACL) reconstructions are common surgical procedures, but a significant number fail for reasons that are not fully understood.
- Trial name
- INFECTIOGEN (NCT07009392)
- Testing
- NGS Analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL - Anterior Cruciate Ligament Rupture
Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction
ACL injuries are incapacitating for both professional and amateur athletes, with long-term repercussions on performance and return to sport (RTS). Surgical reconstruction of the ACL is the main treatment option.
- Trial name
- K-STARTS + (NCT07249645)
- Testing
- Physical tests
- Volunteers
- 230 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament Rupture
Pain Management of ACL Reconstruction
This study will compare the outcome of pain interventions that are considered standard of care during the surgical treatment of ACL injuries.
- Trial name
- NCT03365908
- Testing
- Adductor Canal Nerve Block, Ropivacaine injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery
The purpose of this study is to explore patient outcomes associated with, the use of a 3D printed knee extender device, in conjunction with an at-home rehabilitation program, for patients who are performing knee rehabilitation…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06524349
- Testing
- 3D printed knee extender device
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Sanford Health
ACL - Anterior Cruciate Ligament Rupture
Influence of the Different Types of Tibial Fixation in the Reconstruction of the Anterior Cruciate Ligament of the Knee: Osseous Integration, Ligament Maturation and Clinical Results.
Influence of different tibial fixation methods in anterior cruciate ligament (ACL) reconstruction: bone integration, graft maturation, and clinical outcomes.
- Trial name
- NCT07753707
- Testing
- Anterior cruciate ligament (ACL) reconstruction
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Institut Català de Traumatologia i Medicina de l'Esport
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
ACL - Anterior Cruciate Ligament Rupture, ACL
Use of an Osteoconductive Scaffold in ACL-Reconstruction
Primary objective of the study is to evaluate efficacy of the surgical technique for ACL reconstruction using an osteoconductive scaffold, enlaced into the hamstring tendon autograft, compared to the traditional technique.
- Conditions
- ACL - Anterior Cruciate Ligament Rupture, ACL, ACL Injury
- Trial name
- ACLROCS (NCT03462823)
- Testing
- Osteoconductive scaffold-hamstring tendon composite repair, Hamstring tendon-only repair
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Sandro Fucentese
Anterior Cruciate Ligament Rupture
The Comparison of Tunnel Morphology and Graft Healing in Anterior Cruciate Ligament Reconstructions Using Peroneus Longus And Hamstring Tendons
1. Comparison of the grafts using Magnetic Resonance Imaging (MR) to determine whether their maturation and bone integration are different, 2.
- Trial name
- NCT06769711
- Testing
- Surgical procedure using Peroneus Longus for ACL reconstruction., Surgical procedure using Hamstring tendons for ACL reconstruction.
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Karadeniz Technical University