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Neck Pain Non-Specific Neck Pain Chronic Neck PainNCT07799415

Effects of Exercise on Pain and Quality of Life in Office Workers With Neck Pain

A study of Neck Pain Non-Specific Neck Pain Chronic Neck Pain, run by Sumaya Sadıgova at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This clinical trial aims to learn if a structured exercise intervention helps treat chronic neck pain, reduce neck disability, relieve work-related stress, and improve overall quality of life in office workers. Read more about this study

Who is it for?
Ages 25 to 60 years
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
1 siteTurkey (Türkiye)
Study dates
29 Dec 2025to 10 Apr 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 25 to 60 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Men and women aged 25 to 60 years
  • Currently employed as office workers with continuous computer usage
  • Ability to participate in and adhere to the intervention protocol
  • Diagnosis of chronic non-specific neck pain lasting for more than 3 months

Who cannot join

  • Previous history of physical therapy or rehabilitation for neck pain
  • History of cervical spine surgery
  • Cervical joint instability
  • Diagnosis of migraine or other severe headache disorders
  • Spasmodic torticollis
  • Inflammatory rheumatic diseases (e.g., rheumatoid arthritis, ankylosing spondylitis)
  • Peripheral nerve entrapment syndromes (e.g., cervical radiculopathy, carpal tunnel syndrome)
  • Presence of severe psychiatric disorders

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Istanbul University-Cerrahpasa, Faculty of Health Sciences

    Istanbul, büyükçekmece, 34500

Other trials in Turkey (Türkiye)

About this study

Official title: Effect of Exercise Intervention on Pain, Disability, Job Stress, and Quality of Life in Office Workers With Neck Pain

This clinical trial aims to learn if a structured exercise intervention helps treat chronic neck pain, reduce neck disability, relieve work-related stress, and improve overall quality of life in office workers.

The main questions it aims to answer are:

Read more

Does a targeted exercise intervention significantly reduce neck pain intensity and neck disability in office workers?

Does the exercise program help lower work-related stress levels among office employees?

Does the intervention provide significant improvements in the health-related quality of life of the participants?

Participants will:

Complete a baseline assessment evaluating their current neck pain, functional disability, work-related stress levels, and quality of life using validated clinical questionnaires and measurements.

Engage in a structured exercise program focused on deep neck flexor strengthening, upper back/shoulder strengthening, muscle stretching, and postural alignment.

Complete a post-intervention evaluation immediately following the completion of the exercise program to measure changes in pain, disability, stress, and quality of life.

Read the detailed description
  1. INTRODUCTION

With the digitalization of working life, the center of gravity of work-related musculoskeletal disorders has shifted from occupational sectors dominated by heavy physical loads to office environments characterized by prolonged static loads. The office worker spends the majority of the day in a sitting position, with the head and neck fixed toward the screen and the upper extremities relatively immobile over the keyboard and mouse. When considered individually, this working pattern appears harmless; however, it creates a cumulative mechanical and neuromuscular load on the cervical region, with neck pain emerging as the most visible clinical outcome.

Neck pain ranks among the top contributors to years lived with disability worldwide among musculoskeletal conditions. Global Burden of Disease data show that neck pain is a widespread and persistent public health burden, and this burden will continue to rise as working patterns become increasingly digitalized. A problem so prevalent in the general population becomes even more pronounced in groups with concentrated exposure, such as office workers, where the annual prevalence of neck pain in this population is reported to range between 42% and 63%. Research conducted on computer-using office workers in Turkey also confirms that the most frequently reported musculoskeletal symptom occurs in the neck region.

The vast majority of neck pain observed in office workers is non-specific in nature; meaning no specific identifiable structural pathology can be shown as the source of pain. Nevertheless, the pain significantly impacts the individual's daily living activities, work performance, and psychological well-being. A cluster of interacting mechanisms plays a role in its pathogenesis. Under prolonged static posture, activation of the deep cervical flexor muscles decreases, while compensatory hyperactivation develops in the superficial muscles. This neuromuscular reorganization weakens the dynamic support of the cervical segments, impairs proprioceptive feedback, and creates a vicious cycle that contributes to the persistence of pain. Viewing the issue solely through a biomechanical lens provides an incomplete framework; evidence is growing stronger that psychosocial factors-such as job stress, low job satisfaction, and lack of support-play a decisive role in the onset and chronicity of neck pain.

In the management of non-specific neck pain, exercise currently holds the strongest evidence base among intervention methods. Strengthening, stretching, and motor control exercises targeted at the cervical and scapulothoracic regions have been shown to exert positive effects on pain, disability, and quality of life, while also improving psychosocial outcome measures such as job stress.

The fundamental unanswered question is how this exercise should be delivered. The delivery mode of exercise can directly influence clinical outcomes. Exercise conducted under the supervision of a physiotherapist offers advantages such as real-time correction of movement quality, individualization of progressive loading, and direct monitoring of exercise adherence. In contrast, self-directed exercise supported by videos and mobile reminders stands out for its low cost, temporal/spatial flexibility, and scalability to large populations. However, studies directly comparing physiotherapist-supervised exercise against video/mobile-supported self-directed exercise across multidimensional measures-including pain, disability, range of motion, job stress, and quality of life-remain limited.

This study aims to investigate the effects of a six-week exercise program on pain intensity, neck-related disability, cervical range of motion, job stress, and health-related quality of life in office workers with non-specific neck pain, and to compare these effects between two different delivery modes (physiotherapist-supervised vs. video/mobile-supported).

---

## 2. CONCEPTUAL FRAMEWORK

### 2.1. CERVICAL REGION ANATOMY AND BIOMECHANICS

The cervical spine is the most mobile and mechanically sensitive segment of the spinal column. Consisting of seven vertebrae, this segment is responsible for supporting the head-which weighs an average of 4-5 kg-orienting it across a wide range of motion in three planes, while simultaneously protecting the spinal cord and vertebral arteries passing through it. This mandatory trade-off between mobility and stability is key to understanding the clinical problems of the cervical region: anatomical adaptations made in favor of mobility reduce the load on passive stabilizers and increase the load on active stabilizers (muscles and neuromuscular control).

#### Anatomical Segmentation and Joint Complexes

  1. Upper Cervical Region (Craniocervical Junction): Encompasses the Occiput, Atlas (C1), and Axis (C2) structures.
  • *Atlas (C1):* Lacks a vertebral body and spinous process. It articulates with the occipital condyles to form the atlanto-occipital joint, which is primarily responsible for the flexion-extension ("nodding") movement of the head.
  • *Axis (C2):* Distinguished by a vertical cylindrical projection called the dens (odontoid process). The dens articulates with the anterior arch and transverse ligament of the atlas, forming the anatomical axis for head rotation. The atlanto-axial joint complex alone provides approximately 50% of total cervical rotation.
  1. Lower Cervical Region (C3-C7): Possesses typical vertebral morphology.
  • Uncinate processes on the superior-lateral margins of the vertebral bodies form the uncovertebral joints (joints of Luschka), limiting lateral flexion and providing segmental stability.
  • *Zygapophyseal (Facet) Joints:* Their 45-degree orientation close to the horizontal plane permits broad rotation and lateral flexion. They possess rich nociceptive innervation.
  • *Intervertebral Discs:* Play a role in absorbing axial loads and distributing segmental movement. #### Layered Structure of the Muscular System Cervical region muscles are categorized functionally into two main groups:
  • Deep Cervical Muscles (Segmental/Local Stabilizers): Anteriorly, the *longus colli* and *longus capitis*; posteriorly, the suboccipital muscles (*rectus capitis posterior major/minor*, *obliquus capitis superior/inferior*), *multifidus*, and *semispinalis cervicis*. They have short moment arms and are responsible for the "neutral zone" stability of the spine. Suboccipital muscles, due to their high muscle spindle density, play a critical role in the proprioceptive control of head-neck position.
  • Superficial Cervical Muscles (Global Torque Generators): Muscles with long moment arms, such as the *sternocleidomastoid (SCM)*, *anterior scalene*, *trapezius* (especially upper fibers), and *levator scapulae*. They are responsible for rapid movement and force production. In individuals with neck pain, excessive and continuous activation (compensation) develops in superficial muscles to compensate for deep muscle insufficiency.
  • Cervicoscapular Biomechanical Interaction Scapular positioning directly impacts the cervical spine. The *levator scapulae* and *trapezius* muscles attach directly to the cervical spine. Upper trapezius dominance combined with lower trapezius and *serratus anterior* weakness-frequently observed in computer workers-leads to scapular protraction and elevation (scapular dyskinesia), thereby increasing cervical loading. --- ### 2.2. NECK PAIN Neck pain is defined as discomfort felt in the region bounded by the superior nuchal line superiorly and the spinous process of the first thoracic vertebra inferiorly, which may radiate to the head or upper extremities. Clinically, cases lasting longer than three months are classified as chronic neck pain. #### Classification and Grading The Bone and Joint Decade Task Force classifies neck pain into four grades:
  • Grade I: No major structural pathology, no or minimal interference with daily activities.
  • Grade II: No major structural pathology, but significant interference with daily activities *(forms the target population of this thesis)*.
  • Grade III: Presence of neurological signs indicating nerve root compression (radiculopathy).
  • Grade IV: Major structural pathology such as tumor, fracture, infection, or myelopathy.
  • Etiology and Risk Factors Non-specific neck pain has a multifactorial etiology:

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  1. Individual Factors: Female gender, older age, elevated BMI, smoking, and history of previous musculoskeletal pain.
  2. Physical / Occupational Factors: Prolonged static sitting posture, continuous duration spent at computer workstations, forward head posture, and repetitive microtraumas.
  3. Psychosocial Factors: High job demands, low decision latitude, insufficient social/managerial support, job stress, anxiety, and pain catastrophizing. #### Pathophysiological Mechanisms
  • Peripheral Nociception and Ischemia: Continuous static muscle contraction increases intramuscular pressure, impairing microcirculation and leading to tissue ischemia, metabolic waste accumulation, and local nociceptor sensitization.
  • Neuromuscular Dysfunction: Delayed or weakened activation of deep flexors (*longus colli/capitis*) during craniocervical flexion results in overactivity of superficial muscles (*SCM*).
  • Central Sensitization: In chronic cases, increased neuronal excitability and impaired nociceptive inhibition lead to the development of allodynia and hyperalgesia. ### 2.3. ERGONOMICS AND WORKPLACE LOADING IN OFFICE WORKERS The exposure profile of office workers is characterized by "low-intensity but prolonged static loading". As time spent at computer workstations increases, mechanical torque on the cervical spine rises; even a 2-3 cm forward shift of the head from neutral posture multiplies the load placed on the extensor musculature. #### Ergonomic Risk Factors and Adjustment Principles
  • Monitor Alignment: Position the top edge of the screen at or slightly below eye level to prevent excessive cervical flexion.
  • Keyboard and Mouse Placement: Support the upper extremities with shoulders relaxed and elbows bent at 90 degrees.
  • Seating Support: Adjustable-height chairs that support lumbar lordosis positively influence the overall postural cascade.
  • Active Breaks: Taking short movement breaks every 30-60 minutes to interrupt static loading restores intramuscular blood flow. While ergonomic adjustments alone show limited evidence in preventing pain, their combination with targeted exercise interventions has been shown to enhance clinical success and functional recovery. --- ### 2.4. EXERCISE APPROACHES IN NECK PAIN MANAGEMENT Exercise holds Level A (First-Line) evidence in the conservative management of neck pain. #### Components of Therapeutic Exercise

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  1. Deep Cervical Flexor (Craniocervical Flexion) Training: Re-education of *longus colli* and *longus capitis* muscles using proprioceptive biofeedback principles while inhibiting superficial muscles.
  2. Scapulothoracic and Cervical Strengthening: Progressive resistance exercises (isometric or dynamic) targeting the *lower/middle trapezius*, *serratus anterior*, and posterior cervical extensors.
  3. Stretching and Mobility Exercises: Stretching shortened *upper trapezius*, *levator scapulae*, and *pectoralis major* muscles to improve tissue compliance.
  4. Relaxation and Breathing Exercises: Increasing parasympathetic tone to reduce sympathetic-induced muscle tension and the physical manifestations of occupational stress. #### Exercise Delivery Modes: Supervised vs. Digital/Self-Directed
  • Physiotherapist-Supervised Exercise: Delivers direct physical and verbal feedback, immediate correction of compensatory movements, and precise progression of loading parameters.
  • Video and Mobile Reminder-Supported Exercise: Uses notifications to maintain compliance; provides a cost-effective, highly scalable option that promotes patient self-efficacy.
  • 2.5. JOB STRESS AND QUALITY OF LIFE Neck pain is not merely a mechanical dysfunction; it represents a condition with clear biopsychosocial dimensions.
  • Job Stress: *Karasek's Job Demand-Control Model* and *Siegrist's Effort-Reward Imbalance Model* explain how occupational stressors trigger musculoskeletal symptoms. Increased sympathetic neuroendocrine discharge maintains chronically elevated muscle tone, predisposing tissues to intramuscular ischemia and heightened nociceptive input.
  • Health-Related Quality of Life: Chronic pain and functional limitation lower both physical component scores (mobility, energy) and mental component scores (emotional state, social functioning). Exercise interventions aim not only to reduce nociception and pain intensity, but also to enhance overall well-being and build individual capacity (self-efficacy) to manage workplace stress. ### REFERENCES

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Being tested
Supervised Therapeutic Exercise Program, Control Grupu
Keywords
Neck Pain, Non-specific Neck Pain, Office Workers, Exercise Therapy, Supervised Exercise, Quality of Life
Medical subject headings
Neck Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Supervised Therapeutic Exercise Program, Control GrupuBehavioural

    1. A 6-week progressive exercise program conducted under the direct physical supervision of a physiotherapist (3 sessions/week, 45 min/session). The program includes deep cervical flexor re-education, scapulothoracic strengthening with elastic resistance bands, upper body stretching, and real-time biomechanical
    2. A 6-week self-directed progressive exercise program supported by instructional videos and a mobile application (3 sessions/week, 40-45 min/session). The exercise content and progression (deep flexor training, scapular strengthening, stretching) mirror the supervised group, but exercises are performed independently using mobile app video guidance and automated log tracking.
Study groups in NCT07799415
Study groupRoleWhat they receive
Physiotherapist-Supervised Exercise GroupExperimentalParticipants in this arm receive a 6-week structured progressive exercise program delivered under the direct, face-to-face supervision of a qualified physiotherapist. The intervention consists of 18 clinical sessions (3 sessions/week, 45 minutes/session). The exercise protocol is divided into three 2-week phases: Phase 1 focuses on deep cervical flexor re-education (longus colli/capitis) using tactile feedback, along with stretching hypertonic upper trapezius and levator scapulae muscles; Phase 2 incorporates elastic band (TheraBand) progressive resistance training targeting the lower/middle trapezius and serratus anterior, alongside seated isometric neck stabilization; Phase 3 emphasizes cervicothoracic dynamic endurance, active range of motion, and postural integration. The physiotherapist provides continuous real-time movement correction, regulates resistance progression, and monitors adverse symptoms during every session.
Receives: Behavioral: Supervised Therapeutic Exercise Program, Control Grupu
Control GroupActive comparatorParticipants in this arm perform an identical 6-week progressive exercise protocol in terms of content, volume, and phased progression; however, the intervention is entirely self-directed without physical physiotherapist presence. Participants access high-definition instructional video demonstrations, movement safety guides, and exercise parameters (sets, reps, hold times) via a dedicated mobile application. The schedule mirrors Arm 1 (3 sessions/week, 40-45 minutes/session for 6 weeks). The mobile platform automatically unlocks Phase 1 (deep flexor activation and stretching), Phase 2 (scapular band exercises), and Phase 3 (dynamic endurance and mobility) every two weeks. Automated app notifications remind participants to complete scheduled sessions, and adherence is logged digitally within the application.
Receives: Behavioral: Supervised Therapeutic Exercise Program, Control Grupu

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Neck Disability Level

    Change in Neck Disability Level

    Measured: Baseline and Week 6 (immediately after the 6-week intervention)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Sep 2026
  2. Study start29 Dec 2025
  3. Primary completion10 Apr 2026
  4. Study completion10 Apr 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
This is a two-arm, parallel-group randomized intervention study. Participants with non-specific neck pain are assigned into one of two parallel groups: Group 1 receives a 6-week physiotherapist-supervised exercise program, while Group 2 receives a 6-week video- and mobile-supported self-directed exercise program. Outcome measures are evaluated at baseline and at the end of the 6-week intervention period.
Masking
None (open label)
Enrolment
40 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07799415
Sponsor's protocol ID
E-83460662-050.04-1570486
Status last verified
Aug 2026
First submitted
30 Aug 2026
Last updated
2 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study of Neck Pain Non-Specific Neck Pain Chronic Neck Pain, run by Sumaya Sadıgova at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 2 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Neck Disability Level (time frame: Baseline and Week 6 (immediately after the 6-week intervention)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Sep 2026.

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