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RunningNEXTGENTRAILNCT07855042

A Multiphase Analysis of Next-generation Trail Footwear

A study testing Running footwear in people with Running and Athletic Performance, run by Fernando González-Mohíno Mayoralas.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
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Trial summary

This study will investigate how different advanced-foam trail-running footwear configurations affect running economy, performance, comfort, and fatigue in competitive trail runners. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Running, Athletic Performance, Oxygen Consumption
What is being tested?
Running footwear
Could I receive a placebo?
No, everyone receives an active treatment
How many people
30 participants
Where
No sites listed yet
Study dates
Nov 2026to Mar 2028
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Competitive trail runners.
  • Experience in technical trail running.
  • Willingness to provide written informed consent.

Who cannot join

  • Musculoskeletal injury in the previous 6 months.

Trial locations and contacts

No sites are listed yet. Contact the study team or a site near you to ask about taking part.

Fernando González-Mohíno, PhD contact

+34 690216354

fernando.gmayoralas@uclm.es

About this study

Official title: A Multiphase Analysis of Next-generation Trail Footwear: Optimising Advanced Footwear Technology From Laboratory Outcomes to Field-based Running Performance

This study will investigate how different advanced-foam trail-running footwear configurations affect running economy, performance, comfort, and fatigue in competitive trail runners. The project aims to determine whether footwear characteristics, particularly foam properties and stack height, influence physiological and biomechanical responses during both controlled laboratory running and real-world trail running.

Approximately 30 competitive trail runners with experience in technical trail running and no musculoskeletal injury during the previous six months will participate. The study will use a two-phase experimental design.

Read more

In Phase 1, participants will complete running economy assessments in three footwear conditions in randomized order. The footwear conditions will include a high-stack advanced-foam prototype, a medium-stack advanced-foam prototype, and a conventional-foam shoe. Laboratory testing will be performed during uphill and downhill treadmill running. Participants will also complete field-based running economy trials on real trail terrain at a controlled speed, followed by a short time trial to establish a representative running pace.

In Phase 2, participants will complete prolonged trail-running sessions in the two advanced-foam footwear configurations on a 15-km trail course. Running economy and fatigue-related responses will be assessed repeatedly during the prolonged exercise sessions to evaluate changes in physiological and biomechanical efficiency over time.

The primary physiological outcome will be running economy, assessed through oxygen consumption and energy cost. Additional outcomes will include heart rate, step frequency, step length, ground contact time, perceived exertion, comfort, perceived performance, and pacing-related measures.

The study will compare laboratory and field responses to determine whether differences in running economy observed under controlled conditions are maintained during real trail running and whether footwear configuration influences the deterioration of running economy and fatigue during prolonged exercise.

Read the detailed description

Trail running involves substantial variations in terrain, gradient, and surface characteristics, creating physiological and biomechanical demands that differ from road running. Footwear may influence these responses through characteristics such as midsole foam properties, cushioning, and stack height. However, evidence regarding advanced footwear technology in trail running remains limited, particularly regarding whether laboratory findings translate to real-world trail conditions and whether footwear characteristics influence the maintenance of running performance during prolonged exercise.

The objective of this study is to investigate the effects of different advanced-foam trail-running footwear configurations on running economy, performance, comfort, biomechanical responses, and fatigue under laboratory and field-based trail-running conditions. The study will also examine whether footwear configuration influences durability, defined in this project as the maintenance of running economy and physiological efficiency during prolonged exercise.

The study will recruit approximately 30 competitive trail runners with experience in technical trail running who have been free from musculoskeletal injury for at least six months. Written informed consent will be obtained from all participants.

The study will use a two-phase experimental design.

In Phase 1, participants will be evaluated under three footwear conditions in randomized order:

  1. High-stack advanced-foam shoe prototype: approximately 38.5 mm stack height, 6-mm drop, and 220 g.
  2. Medium-stack advanced-foam shoe prototype: approximately 28.5 mm stack height, 6-mm drop, and 180 g.
  3. Conventional-foam footwear: approximately 31.5 mm stack height, 6-mm drop, and 300 g.

If necessary, shoe mass will be standardized by adding weight to the lighter footwear configurations to help isolate the effects of foam characteristics.

Laboratory running economy will be assessed using 5-minute running trials under uphill and downhill conditions. Uphill running will be performed at 8 km/h with a 6% positive slope, and downhill running at 16 km/h with a 6% negative slope. Oxygen uptake and carbon dioxide output will be measured breath-by-breath using a metabolic gas analysis system. Biomechanical variables will also be recorded, including step frequency and ground contact time.

Following the laboratory assessment, participants will complete field-based running economy trials on a real trail surface. Each footwear condition will be tested in randomized order during 5-minute running trials at a controlled speed of 12 km/h. Speed will be controlled using acoustic signals. Oxygen consumption and carbon dioxide production will be measured using a portable metabolic system, while spatiotemporal gait variables will be recorded using an inertial measurement device. Participants will subsequently complete a short time trial to establish a representative running pace for the subsequent durability assessment.

In Phase 2, participants will complete prolonged trail-running sessions using the two advanced-foam footwear configurations. Each footwear condition will be assessed during a separate visit. The sessions will consist of repeated running on a 15-km trail course comprising five 3-km loops and approximately 375 m of elevation gain. Running intensity will be based on the pace obtained during the Phase 1 time trial, according to the final study protocol.

Running economy will be assessed repeatedly during the prolonged exercise sessions using portable metabolic measurements. Changes in physiological efficiency and fatigue will be evaluated across the running session. GPS-based measurements will also be collected to monitor pacing and changes in running performance.

The main physiological outcome is running economy, assessed through oxygen consumption and energy cost relative to running speed. Additional physiological, biomechanical, and perceptual outcomes include heart rate, step frequency, step length, ground contact time, rating of perceived exertion, perceived comfort, perceived performance, and pacing-related measures.

The study is designed to determine whether footwear-related differences in running economy identified under controlled laboratory conditions are maintained during real-world trail running. It will also investigate whether advanced-foam footwear configurations influence the deterioration of running economy and fatigue during prolonged trail-running exercise. The findings are intended to contribute to the scientific understanding of interactions between trail-running footwear, biomechanics, physiological responses, and endurance performance.

Being tested
Running footwear
Keywords
Trail running, Running economy, Running footwear, Uphill running, Downhill running

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Running footwearOther

    Three trail running shoes with different characteristics will be compared in terms of their physiological and biomechanical effects.

Study groups in NCT07855042
Study groupRoleWhat they receive
High-Stack Advanced-Foam FootwearExperimentalParticipants will perform the experimental running trials wearing a high-stack advanced-foam trail-running shoe (approximately 38.5 mm stack height, 6 mm drop, and 220 g). This footwear condition will be used to assess running economy, physiological and biomechanical responses, comfort, perceived performance, and fatigue-related changes during laboratory and field-based trail running.
Receives: Other: Running footwear
Medium-Stack Advanced-Foam FootwearExperimentalParticipants will perform the experimental running trials wearing a medium-stack advanced-foam trail-running shoe (approximately 28.5 mm stack height, 6 mm drop, and 180 g). This footwear condition will be used to assess running economy, physiological and biomechanical responses, comfort, perceived performance, and fatigue-related changes during laboratory and field-based trail running.
Receives: Other: Running footwear
Conventional-Foam FootwearActive comparatorParticipants will perform the experimental running trials wearing a conventional-foam trail-running shoe (approximately 31.5 mm stack height, 6 mm drop, and 300 g). This footwear condition will serve as the conventional-footwear comparison for assessing running economy, physiological and biomechanical responses, comfort, perceived performance, and fatigue-related changes during laboratory and field-based trail running.
Receives: Other: Running footwear

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Running economy

    Running economy will be assessed through oxygen consumption (V̇O₂) and energy cost expressed in W·kg-¹ during running in the different footwear conditions. Measurements will be obtained using breath-by-breath gas analysis during controlled laboratory and field-based trail-running trials.

    Measured: During each 5-minute running trial for each footwear model in Phase 1 (indoor laboratory conditions) and Phase 2 (outdoor trail-running conditions).

Secondary outcomes (3)
  1. Heart Rate

    Continuous heart rate will be recorded during the running trials to characterize the physiological response to each footwear condition.

    Measured: During each 5-minute running trial for each footwear model in Phase 1 (indoor laboratory conditions) and Phase 2 (outdoor trail-running conditions).

  2. Spatiotemporal Gait Parameters

    Biomechanical responses will be assessed through step frequency (steps/min), step length (m), and ground contact time (ms) during running in the different footwear conditions.

    Measured: During each 5-minute running trial for each footwear model in Phase 1 (indoor laboratory conditions) and Phase 2 (outdoor trail-running conditions).

  3. Comfort, Perceived Performance, and Rate of Perceived Exertion

    Participants' subjective perceptions of footwear comfort, perceived performance, and rate of perceived exertion will be assessed during the experimental running conditions.

    Measured: After each 5-minute running trial for each footwear model in Phase 1 (indoor laboratory conditions) and Phase 2 (outdoor trail-running conditions).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Oct 2026
  2. Study startNov 2026 (estimated)
  3. Primary completionMar 2028 (estimated)
  4. Study completionMar 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Crossover
Model description
This study uses a two-phase, cross-sectional experimental design combining controlled laboratory assessments with ecological field-based trail-running testing. In Phase 1, participants will complete experimental trials in three footwear conditions. The order of footwear conditions will be randomized. In Phase 2, participants will complete repeated 15-km trail-running sessions using the two advanced-foam footwear configurations. Running economy will be assessed repeatedly during prolonged exercise to investigate changes in physiological cost and the potential durability-related deterioration of footwear performance.
Masking
Single blind
Who is masked
Participant
Enrolment
30 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07855042
Sponsor's protocol ID
CEIS-2026-174642
Other IDs
PID2025-170911NB-I00
Acronym
NEXTGENTRAIL
Status last verified
Sep 2026
First submitted
22 Sep 2026
Last updated
2 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided: The investigators have not yet decided whether individual participant data (IPD) will be shared. A decision regarding IPD sharing will be made after completion of the study, taking into consideration ethical, legal, privacy, and data protection requirements.

Publications

  • Rodrigo-Carranza V, Hoogkamer W, Salinero JJ, Rodriguez-Barbero S, Gonzalez-Rave JM, Gonzalez-Mohino F. Influence of Running Shoe Longitudinal Bending Stiffness on Running Economy and Performance in Trained and National Level Runners. Med Sci Sports Exerc. 2023 Dec 1;55(12):2290-2298. doi: 10.1249/MSS.0000000000003254. Epub 2023 Jul 14.

    PubMed 37443458
  • Rodrigo-Carranza V, Hoogkamer W, Gonzalez-Rave JM, Gonzalez-Mohino F. Relationship Between Advanced Footwear Technology Longitudinal Bending Stiffness and Energy Cost of Running. Scand J Med Sci Sports. 2024 Jun;34(6):e14687. doi: 10.1111/sms.14687.

    PubMed 38923087
  • Rodrigo-Carranza V, Gonzalez-Mohino F, Santos-Concejero J, Gonzalez-Rave JM. Influence of Shoe Mass on Performance and Running Economy in Trained Runners. Front Physiol. 2020 Sep 23;11:573660. doi: 10.3389/fphys.2020.573660. eCollection 2020.

    PubMed 33071828

Questions about this trial

What is this clinical trial studying?

A study testing Running footwear in people with Running and Athletic Performance, run by Fernando González-Mohíno Mayoralas.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Fernando González-Mohíno, PhD (+34 690216354, fernando.gmayoralas@uclm.es), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Running economy (time frame: During each 5-minute running trial for each footwear model in Phase 1 (indoor laboratory conditions) and Phase 2 (outdoor trail-running conditions).). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07855042, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.

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