Virtual RealityReviMedNCT07866417
Implementation of Virtual Reality in Nuclear Medicine
A study testing ReviMed group in people with Virtual Reality, run by Fundacion Miguel Servet at 1 site in Spain.
Trial summary
Introduction: In the field of medicine, diagnostic tests are essential for the early detection and effective treatment of various diseases. However, these tests often cause patients significant pain and anxiety, which can affect their experience and their willingness to undergo future medical procedures. Read more about this study
- Who is it for?
- Ages 2 years and older
- Conditions the study is for
- Virtual Reality
- What is being tested?
- ReviMed group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 250 participants
- Where
- 1 siteSpain
- Study dates
- 1 Mar 2025to 27 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 2 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Diagnostic bone, renal, or perfusion-ventilation scintigraphy
- Glasgow Coma Scale >13
- Adequate communication skills and understanding of the primary language (Spanish or English)
- Age over 2 years
Who cannot join
- Intolerance to devices in the facial area
- Facial malformation
- Acute or significant visual impairment
- Dizziness or discomfort prior to the test
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Implementation of Virtual Reality to Reduce Pain and Anxiety in Nuclear Medicine.
Introduction: In the field of medicine, diagnostic tests are essential for the early detection and effective treatment of various diseases. However, these tests often cause patients significant pain and anxiety, which can affect their experience and their willingness to undergo future medical procedures. The use of Virtual Reality can mitigate these effects, improving the experience and thereby the cooperation of patients undergoing painful and complex procedures.
Objective: To evaluate the effect of using Virtual Reality on pain and anxiety in patients undergoing a complex diagnostic procedure.
Read more
Method: A randomized, parallel-group, 1:1 (control/intervention) superiority trial comparing the use of the conventional technique (Group 1) with the ReViMed technique (Group 2) via random assignment, with a sample size of 72 pediatric patients and 110 adult patients for each arm. The M-YPAS scale will be used to measure anxiety levels in children, and the DASS-21 for anxiety in adult patients; the pain assessment scale for all participants will be the EVA-VAS.
Impact: The implementation of VR use represents an effective distraction process for reducing anxiety and pain experienced by patients undergoing highly complex diagnostic tests.
Read the detailed description
In the field of medicine, diagnostic tests are essential for the early detection and effective treatment of various diseases. However, these tests often cause patients significant pain and anxiety, which can affect their experience and their willingness to undergo future medical procedures. In this context, virtual reality (VR) has emerged as a promising tool for reducing both the pain and anxiety associated with diagnostic tests in both adult and pediatric patients.
VR is a technology that allows users to immerse themselves in computer-generated virtual environments, creating a sense of presence and active participation in a simulated world. Through devices such as virtual reality headsets and motion controllers, users can interact with these environments and experience realistic sensations.
Medical diagnostic and therapeutic tests often involve invasive procedures, physical discomfort, or stressful clinical environments. These factors can generate high levels of pain and anxiety in patients, affecting their emotional well-being and their willingness to cooperate during the procedure. Reducing these negative experiences is crucial for improving the quality of medical care and enabling greater patient cooperation with the procedure to be performed. Several studies have shown that VR can have a positive impact on pain reduction. By distracting the patient's attention and immersing them in a pleasant and relaxing virtual environment, virtual reality can reduce the perception of pain and improve the pain tolerance threshold. Furthermore, the ability to customize virtual environments allows the experience to be tailored to each patient's individual needs and preferences.
VR has also proven effective in reducing anxiety associated with these procedures. By providing a safe and controlled virtual environment, VR can help patients relax, better adapt to the setting, and lower their anxiety levels. Furthermore, gradual exposure to specific medical situations or procedures through virtual reality can help patients become familiar with and desensitized to them, thereby reducing anticipatory anxiety.
- Conditions
- Virtual Reality
- Being tested
- ReviMed group, Control Group (A):
- Keywords
- pain, anxiety
- Medical subject headings
- Pain, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ReviMed groupOther
Incorporation of an interactive experience using virtual reality headsets and 360-degree video projections accompanied by long-form relaxing background music
Control Group (A):Other
no action
| Study group | Role | What they receive |
|---|---|---|
| control group | Other | baseline nuclear medicine imaging without sedation, anxiolytics, or the administration of a relaxant Receives: Other: Control Group (A): |
| Revimed group | Experimental | Virtual reality implementation Receives: Other: ReviMed group |
What is being measured
The primary outcome is the main question the study is designed to answer.
anxiety
The Spanish version of the Modified Yale Preoperative Anxiety Scale (m-YPAS) (EAPY-m, translated into Spanish) will be used (Jerez et al., 2016), which was designed specifically for children aged 2-12 years and has good inter- and intra-observer reliability and good validity (Kain et al., 1997; MacLaren et al., 2009; Sadhasivam et al., 2010). The measurement will be the percentage of patients with anxiety and the mean score for anxiety by intervention group. The measurement will be taken before and after the procedure, immediately following its completion.
Measured: From enrollment to the end of treatment, 1 DAY
Secondary outcomes (2)
level of satisfaction
The measurement will be the mean score for satisfaction by control or intervention group with a liker scale 1-10.
Measured: From enrollment to the end of treatment, 1 DAY
level of pain
EVA-VAS scale: a 0-10 Likert scale. The measurement will be the percentage of patients with pain (yes/no) and the mean score for pain by control and intervention group. The Visual Analog Scale (VAS) is a tool used in clinical settings to measure the intensity of pain or other subjective sensations. It consists of a straight line (usually 10 cm or 100 mm) where one end represents the absence of pain and the other end represents the worst pain imaginable. Values and Meaning of the VAS The measurement is made in centimeters or millimeters, and the values are interpreted as follows: 0: No pain / Absence of pain.0.5-4: Mild pain.4.1-7 cm: Moderate pain. >7: Severe pain / Very intense.10: The worst pain imaginable.
Measured: From enrollment to the end of treatment, 1 DAY
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2026
- Study start1 Mar 2025
- Primary completion1 Mar 2026
- Study completion27 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Virtual RealityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 250 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fundacion Miguel Servet
- Sponsor type
- University, hospital or other
- Collaborators
- Hospital universitario navarra
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07866417
- Sponsor's protocol ID
- MiguelServet
- Other IDs
- GºNa 50/23
- Acronym
- ReviMed
- Status last verified
- Oct 2026
- First submitted
- 27 Mar 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Jung MJ, Libaw JS, Ma K, Whitlock EL, Feiner JR, Sinskey JL. Pediatric Distraction on Induction of Anesthesia With Virtual Reality and Perioperative Anxiolysis: A Randomized Controlled Trial. Anesth Analg. 2021 Mar 1;132(3):798-806. doi: 10.1213/ANE.0000000000005004.
PubMed 32618627Schmitt YS, Hoffman HG, Blough DK, Patterson DR, Jensen MP, Soltani M, Carrougher GJ, Nakamura D, Sharar SR. A randomized, controlled trial of immersive virtual reality analgesia, during physical therapy for pediatric burns. Burns. 2011 Feb;37(1):61-8. doi: 10.1016/j.burns.2010.07.007. Epub 2010 Aug 7.
PubMed 20692769
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Implementation of Virtual Reality to Reduce Pain and Anxiety in Nuclear Medicine.
- ClinicalTrials.gov ID
- NCT07866417
- Acronym / sponsor ID
- ReviMed / MiguelServet
- Conditions
- Virtual Reality
- Keywords
- pain, anxiety
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 250 participants (actual)
- Lead sponsor
- Fundacion Miguel ServetUniversity, hospital or other
- Collaborators
- Hospital universitario navarra
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 1 Mar 2026 (actual)
- Study completion
- 27 Mar 2026 (actual)
- First posted
- 8 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Introduction: In the field of medicine, diagnostic tests are essential for the early detection and effective treatment of various diseases. However, these tests often cause patients significant pain and anxiety, which can affect their experience and their willingness to undergo future medical procedures. The use of Virtual Reality can mitigate these effects, improving the experience and thereby the cooperation of patients undergoing painful and complex procedures.
Objective: To evaluate the effect of using Virtual Reality on pain and anxiety in patients undergoing a complex diagnostic procedure.
Method: A randomized, parallel-group, 1:1 (control/intervention) superiority trial comparing the use of the conventional technique (Group 1) with the ReViMed technique (Group 2) via random assignment, with a sample size of 72 pediatric patients and 110 adult patients for each arm. The M-YPAS scale will be used to measure anxiety levels in children, and the DASS-21 for anxiety in adult patients; the pain assessment scale for all participants will be the EVA-VAS.
Impact: The implementation of VR use represents an effective distraction process for reducing anxiety and pain experienced by patients undergoing highly complex diagnostic tests.
Detailed description
In the field of medicine, diagnostic tests are essential for the early detection and effective treatment of various diseases. However, these tests often cause patients significant pain and anxiety, which can affect their experience and their willingness to undergo future medical procedures. In this context, virtual reality (VR) has emerged as a promising tool for reducing both the pain and anxiety associated with diagnostic tests in both adult and pediatric patients.
VR is a technology that allows users to immerse themselves in computer-generated virtual environments, creating a sense of presence and active participation in a simulated world. Through devices such as virtual reality headsets and motion controllers, users can interact with these environments and experience realistic sensations.
Medical diagnostic and therapeutic tests often involve invasive procedures, physical discomfort, or stressful clinical environments. These factors can generate high levels of pain and anxiety in patients, affecting their emotional well-being and their willingness to cooperate during the procedure. Reducing these negative experiences is crucial for improving the quality of medical care and enabling greater patient cooperation with the procedure to be performed. Several studies have shown that VR can have a positive impact on pain reduction. By distracting the patient's attention and immersing them in a pleasant and relaxing virtual environment, virtual reality can reduce the perception of pain and improve the pain tolerance threshold. Furthermore, the ability to customize virtual environments allows the experience to be tailored to each patient's individual needs and preferences.
VR has also proven effective in reducing anxiety associated with these procedures. By providing a safe and controlled virtual environment, VR can help patients relax, better adapt to the setting, and lower their anxiety levels. Furthermore, gradual exposure to specific medical situations or procedures through virtual reality can help patients become familiar with and desensitized to them, thereby reducing anticipatory anxiety.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control group | Other | Other: Control Group (A):baseline nuclear medicine imaging without sedation, anxiolytics, or the administration of a relaxant |
| Revimed group | Experimental | Other: ReviMed groupVirtual reality implementation |
Who may qualify
- Ages
- 2 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- Diagnostic bone, renal, or perfusion-ventilation scintigraphy
- Glasgow Coma Scale >13
- Adequate communication skills and understanding of the primary language (Spanish or English)
- Age over 2 years
Key exclusion criteria (4 listed)
- Intolerance to devices in the facial area
- Facial malformation
- Acute or significant visual impairment
- Dizziness or discomfort prior to the test
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ReviMed groupIncorporation of an interactive experience using virtual reality headsets and 360-degree video projections accompanied by long-form relaxing background music | Other | Revimed group |
| Control Group (A):no action | Other | control group |
Primary outcome
anxiety
Time frame: From enrollment to the end of treatment, 1 DAY
The Spanish version of the Modified Yale Preoperative Anxiety Scale (m-YPAS) (EAPY-m, translated into Spanish) will be used (Jerez et al., 2016), which was designed specifically for children aged 2-12 years and has good inter- and intra-observer reliability and good validity (Kain et al., 1997; MacLaren et al., 2009; Sadhasivam et al., 2010). The measurement will be the percentage of patients with anxiety and the mean score for anxiety by intervention group. The measurement will be taken before and after the procedure, immediately following its completion.
2 secondary outcomes
level of satisfaction
Time frame: From enrollment to the end of treatment, 1 DAY
level of pain
Time frame: From enrollment to the end of treatment, 1 DAY
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Background: PubMed 32618627Jung MJ, Libaw JS, Ma K, Whitlock EL, Feiner JR, Sinskey JL. Pediatric Distraction on Induction of Anesthesia With Virtual Reality and Perioperative Anxiolysis: A Randomized Controlled Trial. Anesth Analg. 2021 Mar 1;132(3):798-806. doi: 10.1213/ANE.0000000000005004.
- Background: PubMed 20692769Schmitt YS, Hoffman HG, Blough DK, Patterson DR, Jensen MP, Soltani M, Carrougher GJ, Nakamura D, Sharar SR. A randomized, controlled trial of immersive virtual reality analgesia, during physical therapy for pediatric burns. Burns. 2011 Feb;37(1):61-8. doi: 10.1016/j.burns.2010.07.007. Epub 2010 Aug 7.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ReviMed group in people with Virtual Reality, run by Fundacion Miguel Servet at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
anxiety (time frame: From enrollment to the end of treatment, 1 DAY). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07866417, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026; AzTrials last refreshed its copy on 4 Nov 2026.