Clinical trials: Acid Base Disorder
PKU, Phenylketonurias
Market Research - Acceptability Study for a New PKU Protein Substitute
The aim of this study is to demonstrate that a new protein substitute is acceptable and well tolerated in children with PKU.
- Conditions
- PKU, Phenylketonurias, Inborn Errors of Metabolism, Metabolic Disease
- Trial name
- NCT04318509
- Testing
- GMPOWER
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people
- Sponsor
- Dr. Schär AG / SPA
HIV, Hepatitis B
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study is a prospective observational cohort study of 23,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina.
- Conditions
- HIV, Hepatitis B, Hepatitis C, AIDS
- Trial name
- EuroSIDA (NCT02699736)
- Where
- 110 sites in Argentina, Austria and 34 more
- Volunteers
- 23,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Chronic Daily Headache
Atkins Diet for Difficult-to-Control Headaches in Teenagers
This is a 3-month pilot study of 10 adolescents with chronic daily headache. Teens will be placed on a modified Atkins diet and followed with 2 subsequent visits to assess for headache improvement.
- Trial name
- NCT00181064
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Type 1 Diabetes, Celiac Disease
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies.
- Trial name
- PLEDGE (NCT04477928)
- Testing
- Sera and whole blood sampling, Differential Gene Expression (DGE)
- Where
- 4 sites in United States
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Anemia
School-Based Assessment of Micronutrient Interventions in Adolescents (SAMIA) in Zanzibar
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and school performance/attendance among in-school adolescents in Zanzibar…
- Trial name
- SAMIA (NCT05104554)
- Testing
- Iron and folic acid (IFA), Multiple Micronutrient Supplement (MMS)
- Where
- Tanzania
- Volunteers
- 2,480 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Starvation, Caesarean Section
Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study
The primary aim of this randomised control trial is to assess the impact of pre-operative carbohydrate loading on the incidence of urinary ketone bodies when compared to standard care in elective caesarean section.
- Trial name
- NCT03220997
- Testing
- Vitaflow Preload
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Anemia
School-Based Assessment of Micronutrient Interventions in Adolescents in Burkina Faso
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status, school performance/attendance and development outcomes among adolescents in…
- Trial name
- SAMIA (NCT04657640)
- Testing
- Iron and folic acid (IFA), Multiple Micronutrient Supplements (MMS) and loading dose of Iron and Folic Acid (IFA)
- Where
- Burkina Faso
- Volunteers
- 3,123 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Phenylketonurias
A 16 Week Study Evaluating the Introduction of a GMP Based Protein Substitute in Participants With PKU
This study aims to measure changes in participants' blood phenylalanine (Phe) levels in participants with PKU when switching from a conventional amino acid based protein substitute to a GMP based protein substitute (PKU Sphere)…
- Trial name
- GMP In PKU (NCT03771391)
- Testing
- PKU Sphere
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Vitaflo International, Ltd
Diabetes Mellitus
EtCO2 for Monitoring and Predicting Severity of DKA in Pediatric Emergency, Doha, Qatar.
Metabolic acidosis is one of the important and life-threatening pathophysiological changes in DKA and its monitoring is essential.
- Trial name
- NCT04121572
- Testing
- Nasal cannula capnography
- Where
- Qatar
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Diabetes Mellitus, Lactic Acidosis
Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media.
- Trial name
- NCT01873859
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 166 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Morbid Obesity, Bariatric Surgery Candidate
Preoperative Condition in Giant Obese Patients
The frequency of super-super obese who need immediate weight loss surgery is risen continuously. For those patients a prior-to-surgery conditioning therapy is mandatory to gain technical and physical operability.
- Trial name
- NCT02616003
- Testing
- Liraglutide, Aminosteril hepa 8%, Caloric diet with 1000 kcal
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
Fetal Distress, Stillbirth
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
This study is a pilot study taking place in Moshi, Tanzania at the Kilimanjaro Christian Medical Centre (KCMC). The study aims to introduce fetal scalp stimulation into the intermittent auscultation protocols at KCMC, and to…
- Conditions
- Fetal Distress, Stillbirth, Birth Asphyxia, Acidosis
- Trial name
- NCT02862925
- Testing
- Fetal Scalp Stimulation
- Where
- Tanzania
- Volunteers
- 550 people
- Sponsor
- Duke University
Hyperventilation Syndrome, Hypocapnia
Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
Hyper Ventilation Syndrome is a frequent disease affecting adults whose diagnosis is often belated or even unrecognized due to the lack of "gold standard" criteria.
- Conditions
- Hyperventilation Syndrome, Hypocapnia, Alkalosis, Respiratory, Hyperventilation
- Trial name
- TCvsPETCO2 (NCT03614806)
- Testing
- Simultaneous Transcutaneous and End-tidal CO2 measurements
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Rouen
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt
Enamel Discoloration, Fluorosis, Dental
21% Hydrochloric Acid Based Versus 6.6 % Hydrochloric Based Micro Abrasive Kit in Management of Patients With Mild to Moderate Fluorosis
compare the clinical performance of different concentrations of hydrochloric acid based as micro abrasive kits in management of patients with mild to moderate fluorosis over 6month follow up .
- Trial name
- NCT06949878
- Testing
- Antivet, opalustre
- Volunteers
- 35 people
- Sponsor
- Cairo University
Metabolic Acidosis, Neonatal Disease
Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition
The goal of this clinical trial is to learn if the addition of sodium acetate in neonatal PN works to prevent and treat metabolic acidosis and associated comorbidities in preterm neonates.
- Conditions
- Metabolic Acidosis, Neonatal Disease, Neonatal Complication
- Trial name
- PROTECT (NCT06545565)
- Testing
- sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN.
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Phenylketonurias
Evaluation of PKU Sphere
A prospective, open-label study of PKU Sphere in patients with PKU following a phenylalanine restricted therapeutic diet.
- Trial name
- NCT03419819
- Testing
- PKU Sphere
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vitaflo International, Ltd
Metabolic Acidosis, Diabetic Ketoacidosis
Diabetic Ketoacidosis Diagnosis and Management
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
- Conditions
- Metabolic Acidosis, Diabetic Ketoacidosis, Brain Edema
- Trial name
- NCT06327737
- Testing
- Capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Akdeniz University
Epilepsy, Drug Resistant Epilepsy
Ketonemia Through Menstrual Cycle
Ketogenic dietary therapies (KDTs) are well-established, safe, non-pharmacologic treatments used for children and adults with drug-resistant epilepsy and other neurological disorders.
- Conditions
- Epilepsy, Drug Resistant Epilepsy, GLUT1DS1, Ketogenic Dieting
- Trial name
- KETOMENS (NCT05234411)
- Testing
- Evaluation of ketogenic diet impact on ketonemia
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Pavia