Clinical trials: Acute Chest Pain
Pain Crisis
Natural History of Sickle Cell Disease
This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical, translational and basic research studies, or as medically indicated.
- Trial name
- NCT00081523
- Where
- 3 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chest Pain, Diabetes Mellitus
Chest Pain Symptoms Differences Between Diabetic Patients and Non
Cardiovascular disease is the most severe cause of death among all non-infectious diseases and accountable for 17.5 million deaths in the world.
- Trial name
- chestpaindm (NCT06718374)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction
Kitasato PCI Registry
The Kitasato PCI Registry is a single-center, observational, prospective study. This study aims to investigate the impact of characteristics in clinical manifestation, patients' background, procedure of percutaneous coronary…
- Conditions
- Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction, NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, Atherosclerosis
- Trial name
- NCT05308329
- Testing
- Intra-coronary imaging device, PCI procedural characteristics
- Where
- Japan
- Volunteers
- 4,500 people
- Sponsor
- Kitasato University
Pain, Sickle Cell Disease
Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally
The pathophysiology of sickle cell disease (SCD) manifestations, are complex with interactions of intracellular hemoglobin, membrane and endothelial activation but the hallmark remains recurrent and painful vaso-occlusive…
- Trial name
- COMPARE (NCT01380197)
- Testing
- Morphine, Nubain
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Nerve Block, Nephrectomy, Analgesia
QLB Versus PVB for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy
This trial is a prospective, randomized, single-center, open-label, parallel-arm, blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular quadratus lumborum block (TMQLB) in the pain relief and…
- Trial name
- NCT03975296
- Testing
- preoperative single-shot TMQLB, preoperative single-shot TPVB, patient controlled intravenous analgesia(PCIA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cui Xulei
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome
In patients with chest pain the diagnosis of a heart attack (myocardial infarction) is made where there is evidence of heart muscle damage using a blood test to measure the heart muscle protein troponin.
- Trial name
- High-STEACS (NCT01852123)
- Testing
- High-sensitivity troponin I assay
- Where
- United Kingdom
- Volunteers
- 48,282 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Stable Angina
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
Prospective, multi-center, registry designed to enrol up to 2,000 patients in up to 35 International centers. All patients will receive a BioMatrix AlphaTM stent as per clinical practice and will be followed for 2 years for data…
- Conditions
- Coronary Artery Disease, Stable Angina, Ischemia, Acute Coronary Syndrome
- Trial name
- NCT02871622
- Testing
- BioMatrix AlphaTM
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Biosensors Europe SA
Acute Coronary Syndromes
Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine
- Trial name
- NCT00718406
- Testing
- Metoprolol, metoprolol plus morphine
- Where
- Sweden
- Sponsor
- Sahlgrenska University Hospital
Acute Coronary Syndrome
MCG for Risk Stratifications of Patients With Chest Pain
This prospective cohort study is aimed at identification and risk stratification of patients who have symptoms of acute chest pain suspected with acute coronary syndrome （ACS） using Magnetocardiography （MCG）.
- Trial name
- NCT06316011
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 3,620 people
- Sponsor
- Qilu Hospital of Shandong University
Postoperative Pain
Prediction of Acute Postoperative Pain and Analgesic Consumption
Pain is an expected part of surgical recovery but effective pain management remains challenging. The high variability in postoperative pain experience and analgesic treatment response between patients is part of the challenge.
- Trial name
- MIRPEX-3 (NCT02230865)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Kasper Grosen
Hemoglobin SC Disease
Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes. Hemoglobin SCD (HbSC) is a form of SCD that is characterized by dense red blood cells.
- Trial name
- NCT00532883
- Testing
- Hydroxyurea, Magnesium Pidolate
- Where
- 19 sites in United States
- Volunteers
- 44 people
- Sponsor
- St. Jude Children's Research Hospital
Nerve Block, Nephrectomy, Analgesia
TMQLB Versus TPVB for Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery
This trial is a prospective, randomized, single-center, open-label, parallel-arm, blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular quadratus lumborum block (TMQLB) in the pain relief and…
- Trial name
- NCT03414281
- Testing
- TMQLB group 1, TMQLB group 2, TPVB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cui Xulei
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Acute Coronary Syndrome
A Comparison of the TIMI, GRACE and HEART Scores
Various elements of patient history are checked and entered in the admission Case Recor Form (CRF). Three risk scores are calculated out of these elements, combined with physical examination, laboratory values and ECG-findings.
- Trial name
- HEART (NCT01398631)
- Where
- 10 sites in Netherlands
- Volunteers
- 2,440 people
- Sponsor
- R&D Cardiologie
Heart Diseases, Cardiovascular Diseases
Acute Cardiac Ischemia in Women in the ACI/TIPI Trial
To conduct a series of five inter-related studies on acute cardiac ischemia (ACI) in women.
- Conditions
- Heart Diseases, Cardiovascular Diseases, Angina Pectoris, Myocardial Ischemia
- Trial name
- NCT00005701
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Postoperative Pain, Thoracic Surgical Procedures
Transcutaneous Electrical Nerve Stimulation for Acute Postoperative Pain After Video-Assisted Thoracoscopic Surgery
This randomized, double-blind, sham-controlled study aims to evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on acute postoperative pain, sleep quality, and quality of life in patients undergoing…
- Trial name
- NCT07732764
- Testing
- Active TENS
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Fooyin University
Acute Myocardial Infarction, Unstable Angina
Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study
The EMERALD II study is a multinational, multicenter, and retrospective study. ACS patients who underwent CCTA from 1 months to 3 years prior to the event will be retrospectively identified.
- Trial name
- EMERALD II (NCT03591328)
- Testing
- Coronary CT angiography
- Where
- South Korea
- Volunteers
- 429 people
- Sponsor
- Seoul National University Hospital