Clinical trials: Adolescent Overweight
Prader-Willi Syndrome, Hyperphagia
Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome
The investigators propose a randomized double-blind 8 week treatment trial of intranasal oxytocin (IN-OXT) vs. placebo in 24 subjects aged 5 to 18 years with PWS in order to assess IN-OXT's affect on (1) Eating behaviors (2)…
- Trial name
- OXT-PWS (NCT02629991)
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Montefiore Medical Center
Obesity, Overweight
Mobile Attention Retraining in Overweight Female Adolescents
Background: People are constantly exposed to unhealthy foods. Some studies of adults show that training attention away from unhealthy foods might reduce overeating.
- Conditions
- Obesity, Overweight, Binge Eating, Healthy Volunteers
- Trial name
- NCT02977403
- Testing
- Attention Bias Retraining
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bipolar Disorder
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs
A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs.
- Trial name
- MOBILITY (NCT02515773)
- Testing
- Metformin, healthy lifestyle intervention (LIFE)
- Where
- 29 sites in United States
- Volunteers
- 1,565 people
- Sponsor
- Melissa Delbello
Type 2 Diabetes, Diabetes Type 2
Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
The current protocol plans to enroll participants with youth-onset Type 2 Diabetes (T2D) as well as obese and lean controls from the Renal-HEIR - Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2…
- Conditions
- Type 2 Diabetes, Diabetes Type 2, Diabetic Nephropathies, Nephropathy
- Trial name
- HEIRitage (NCT05530356)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Pediatric Obesity, Weight Loss
Our Lifestyles Our Lives
The purpose of the study was to examine the influence of step goals with pedometers to improve children's weight loss, physical activity, and psychosocial health during behavioral treatment.
- Trial name
- OLOL (NCT02965729)
- Testing
- Family-based weight management, Pedometer, Individualized step goals
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Adolescent Obesity, Adolescent Overweight
Helping Educate and Advance Learning Through Healthy Bite-Sized Eating Strategies
The goal of this clinical trial is to compare the effectiveness of a mobile health intervention in adolescents (14-17 years) with overweight or obesity.
- Conditions
- Adolescent Obesity, Adolescent Overweight, Diet, Healthy
- Trial name
- HEALTHY BITES (NCT06082830)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity, Adolescent
Promoting Resilience to Food Commercials Decreases Susceptibility to Unhealthy Food Decision-Making
The purpose of this study is to evaluate how food commercials influence food choices in children and their parents.
- Trial name
- NCT04905498
- Testing
- Commercial Advertising Literacy Training, Control
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Adolescent Obesity
Mobile Health Intervention to Identify Early Responders to Treatment in Adolescent Obesity
Background: The Expert Committee on the Assessment, Prevention and Treatment of Child and Adolescent Overweight and Obesity recommends a staged based approach to the management of adolescents with overweight and obesity from…
- Trial name
- NCT03561597
- Testing
- Mobile health intervention
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- KK Women's and Children's Hospital
Prader-Willi Syndrome
Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is one of the most common genetic causes of obesity. Obesity is a major source of morbidity and mortality in this population.
- Trial name
- NCT01444898
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Los Angeles
Prader-Willi Syndrome, Hyperphagia
Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome
This study is a phase 2 randomized double blind 8-week treatment trial of intranasal OXT vs. placebo in 50 subjects aged 5 to 17 years with PWS in order to assess IN-OXT's affect on measurements of (1) eating behaviors (2)…
- Trial name
- NCT03197662
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Eric Hollander
Binge Eating, Eating Disorders in Adolescence
Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating
This study will develop and test a cognitive-behavioral intervention for adolescents with binge/loss-of-control eating.
- Conditions
- Binge Eating, Eating Disorders in Adolescence, Overweight and Obesity
- Trial name
- NCT04088097
- Testing
- Cognitive-Behavioral Therapy for Adolescent Binge/Loss-of-Control Eating, Control Condition
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Obesity, Childhood
Time Limited Eating in Adolescents (Time LEAd): a Pilot Study
The investigators propose a randomized controlled trial in 90 children (age 13-21y) with obesity recruited from clinical programs at the Children's Hospital Los Angeles (CHLA).
- Trial name
- TimeLEAd (NCT03954223)
- Testing
- Low sugar and carbohydrate diet, Time Limited Eating, Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Obesity, Meal Timing
Impact of Meal Timing on Glycemic Profile in Latino Adolescents With Obesity
In adolescents, conventional obesity treatment comprehensively addresses nutritional, activity, and behavioral topics. Due to limited resources in historically marginalized communities, implementation of nutrition-based…
- Trial name
- NCT05391438
- Testing
- Meal-timing
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's Hospital Los Angeles
Childhood Obesity
Translational Investigation of Growth and Everyday Routines in Kids
The purpose of this study is to determine the effect of severe obesity on physical activity, sedentary behavior and cardiometabolic risk factors during childhood and adolescence and whether these associations are modified by…
- Trial name
- TIGER Kids (NCT02784509)
- Where
- United States
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Energy Balance
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
The objective of the study is to quantify the relationship between physical activity, metabolic function, and appetite in adolescents.
- Conditions
- Obesity, Energy Balance, Appetite, Metabolism
- Trial name
- AAAA2INT (NCT05443347)
- Testing
- Aerobic exercise, Newsletter
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Obesity, Metabolic Disease
Activity, Adiposity, and Appetite in Adolescents 2
Our goal is to examine linkages between physical activity, appetite control, and energy metabolism in adolescents. The investigators will assess metabolic function and appetite control in male and female adolescents stratified by…
- Conditions
- Obesity, Metabolic Disease, Insulin Sensitivity
- Trial name
- AAAA2 (NCT04028921)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Children's Mercy Hospital Kansas City
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio