Clinical trials: Bacterial Growth
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Diarrhea
Slow Versus Rapid Rehydration of Severely Malnourished Children
The recommendation for correction of dehydration of severely malnourished children with diarrhoea includes oral rehydration and if parenteral rehydration is necessary (for example, in severe dehydration) to infuse intravenous…
- Trial name
- NCT02216708
- Testing
- Rapid dehydration, Slow rehydration
- Where
- Bangladesh
- Volunteers
- 208 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera, Diarrhea
Cholera-Hospital-Based-Intervention-for-7-days
The Cholera Hospital Based Intervention for 7 Days (CHoBI7) randomized controlled trial for transition to scale aimed to: (1) Develop and evaluate scalable approaches to integrate the CHoBI7 intervention into the services…
- Conditions
- Cholera, Diarrhea, Stunting
- Trial name
- CHoBI7 (NCT04008134)
- Testing
- CHoBI7 health facility program, CHoBI7 mHealth program, CHoBI7 home visit program
- Volunteers
- 2,626 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pregnancy, Neonatal Mortality
Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model.
- Conditions
- Pregnancy, Neonatal Mortality, Tuberculosis, Hepatitis B
- Trial name
- SPHERES (NCT07126041)
- Testing
- Prescription for Action (SPHERES Model)
- Where
- 2 sites in Indonesia
- Volunteers
- 1,750,000 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Orthodontic Retainers
Biological Reaction of Direct 3d Printed Retainers
The aim of this study will be to evaluate the biological reaction of direct three dimensional printed retainers. Primary objective is to evaluate bacterial growth and color stability between different thicknesses of 3d printed…
- Trial name
- NCT07098325
- Testing
- retainer with .5 mm thickness, retainer with 1 mm thickness
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Al-Azhar University
Failure to Thrive, Infection, Bacterial
High Calorie Formula Intervention on Weight, Length Increment, Total Lymphocyte Counts, TNF-alpha and IGF-1 in Failure to Thrive Children
High calorie formula (Oral Nutrition Supplement/ONS) are products used for oral nutrition support with the aim to increase the nutritional intake. they are a nutrition treatment option children with limited intake.
- Conditions
- Failure to Thrive, Infection, Bacterial, Growth Faltering
- Trial name
- NCT05333133
- Testing
- high calorie formula (oral nutritional supplement/ONS)
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Airlangga
Growth
Evaluation of Safety, Growth, Tolerance and Effects on the Intestinal Fora of a New Milk for Healthy Infants
The purpose of the study is to assess growth and tolerance in new born and infant fed an experimental infant formula with reduced total protein concentration, enriched in alpha-lactalbumin and containing a symbiotic.
- Trial name
- Pétunia (NCT00920166)
- Testing
- Pétunia 1, Regular formula
- Where
- 4 sites in France
- Volunteers
- 97 people
- Sponsor
- Sodilac
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Tuberculosis, Tuberculosis, Multidrug-Resistant
Global Consortium for Drug-resistant Tuberculosis Diagnostics
The goal of this study is to evaluate time to diagnosis for three assays (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay [MODS]) to detect resistance to first and second-line anti-tuberculosis…
- Trial name
- GCDD (NCT02170441)
- Where
- 3 sites in India, Moldova and 1 more
- Volunteers
- 1,128 people
- Sponsor
- University of California, San Diego
Cystic Fibrosis, Lung Disease
Benefits and Risks of Newborn Screening for Cystic Fibrosis
Although cystic fibrosis (CF) is the most common, life-threatening autosomal recessive genetic disorder of the white population, there are often delays in diagnosis and hence start of treatment.
- Conditions
- Cystic Fibrosis, Lung Disease, Pseudomonas Infections
- Trial name
- NCT00014950
- Testing
- CF newborn screening
- Where
- 2 sites in United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Child Growth, Diversity of Microbiome
MORDOR II Burkina Faso: Longitudinal Trial
Globally, childhood mortality has shown a promising downward trend in recent years, however, many sub-Saharan countries still have relatively high child mortality rates.
- Conditions
- Child Growth, Diversity of Microbiome, Child Mortality, Resistance Bacterial
- Trial name
- GAMIN (NCT03676751)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diarrhea Infectious, Shigella
The Impact of Shigellosis and Recommended Treatment in Children
The purpose of this study is to evaluate whether antibiotic treatment of non-dysentery Shigella associated watery diarrhea (NDSD) cases improves clinical outcomes and growth in children.
- Conditions
- Diarrhea Infectious, Shigella, Growth & Development
- Trial name
- TrtNDSD (NCT07433426)
- Testing
- Azithromycin
- Where
- 4 sites in Bangladesh, Zambia
- Volunteers
- 700 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Infection, Bacterial, Antibiotic Resistant Infection
Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.
Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage.
- Conditions
- Infection, Bacterial, Antibiotic Resistant Infection, Diagnostic Self Evaluation, Meningitis, Bacterial
- Trial name
- NCT03252028
- Where
- 2 sites in Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fariba Nayeri
Stunting, Malnutrition; Protein
Protein Plus: Improving Infant Growth Through Diet and Enteric Health
This cluster-randomized controlled trial is designed to address linear growth faltering in 6-12-mo-old Bangladesh infants through a proof-of-concept package of interventions to a) increase intake of high quality protein and b)…
- Conditions
- Stunting, Malnutrition; Protein, Enteric Pathogens, Campylobacter Infections
- Trial name
- JiVitA-6 (NCT03683667)
- Testing
- Azithromycin Oral Product, Protein Supplement, Isocaloric Supplement
- Where
- Bangladesh
- Volunteers
- 5,283 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Premature Infants, Stool Bacterial Composition
Effects of Probiotic and Prebiotic Combinations on Premature Infants
The purpose of this study is to see how oral preparations containing both probiotics and prebiotics impact the growth, bacterial colonization of the intestines, and fecal short chain fatty acid content in premature infants.
- Conditions
- Premature Infants, Stool Bacterial Composition, Growth
- Trial name
- NCT00282113
- Testing
- ProBioPlus, Culturelle
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Stunting, Underweight
Spirulina Supplementation and Infant Growth, Morbidity and Motor Development
Background: In developing countries, micronutrient deficiency in infants is associated with growth faltering, morbidity, and delayed motor development.
- Conditions
- Stunting, Underweight, Pneumonia, Pneumocystis, Cough
- Trial name
- NCT03523182
- Testing
- Spirulina, Control
- Where
- Zambia
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Programme Against Malnutrition
Malnutrition; Mild, Iron-deficiency Anemia
The Effect of Fortified Growing-up Milk on Growth and Micronutrient Status of Nigerian Toddlers
It is well known than an important part of Nigerian children from the lower social economic class have nutrient deficiencies. Fortified products, such as growing up milks (GUM), may play an important role in reducing the risk and…
- Conditions
- Malnutrition; Mild, Iron-deficiency Anemia, Nutritional Stunting, Nutritional Wasting
- Trial name
- GaGA (NCT03411590)
- Testing
- Fortified milk Powder
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina WAMCO Nigeria PLC
Testing Effect of Intervention
Zinc Supplementation in Shigella Patients
Shigellosis is a major cause of morbidity and mortality in young children in Bangladesh and other developing countries. Further, the increasing emergence of resistance to a wide range of antibiotics is of great concern.
- Trial name
- NCT00321126
- Testing
- Children in the zinc group received 20 mg of elemental zinc as acetate per day in a twice-daily dose for two weeks.
- Volunteers
- 56 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Growth of Infants
Addition to Infant Formula of 2-fucosyllactose (2-FL)
OBJECTIVES: Primary: The primary objective is to determine whether the mean weight gain over a 16-week interval starting on or before 14 days of life differs between infants fed one of two infant formulas as their sole source of…
- Trial name
- 2-FL (NCT03109223)
- Testing
- sole source nutrition
- Where
- 6 sites in United States, Honduras
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- PBM Nutritionals