Clinical trials: Behavior And Behavior Mechanism
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression and CVD
Study on the Mechanism of Multi-group Analysis of the Influence of Depression on Common Cardiovascular Diseases
Cardiovascular disease is the main cause of death in the world, accounting for 32% of all deaths. In 2019, the number of people suffering from cardiovascular diseases in the world was about 523 million, of which about 18.6…
- Trial name
- NCT06975592
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder
Characterization and Brain Mechanisms of Frustration in Youth With Severe Irritability or Attention Deficit Hyperactivity Disorder (ADHD)
Background: Irritability is an elevated proneness to anger. Children with irritability have difficulty tolerating frustration. They get angry and have temper outbursts more easily than their others their age.
- Conditions
- Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder, Normal Physiology
- Trial name
- NCT05357495
- Testing
- Affective Posner fMRI frustration induction task
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Self Esteem, Suicide and Self-harm
Self-Esteem: A Protective Mechanism for Adolescent Mental Health
This study will explore the effects of the Injeti Self-Love Model intervention on adolescents challenged with low-self-esteem leading to self-harming, suicidal thoughts and suicidal attempts.
- Trial name
- NCT04296812
- Testing
- Self-Love Model
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Loma Linda University
Autism Spectrum Disorder
Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders
This study is a prospective, multicenter, randomized, single-blind controlled trial to enroll 200 children with autism spectrum disorders (ASD).
- Trial name
- NCT05927792
- Testing
- repeated transcranial magnetic stimulation (continuous theta-burst stimulation)
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Behavior and Behavior Mechanisms, Health Knowledge, Attitudes, Practice
Learning and Living With Wildfire Smoke
The proposed intervention in this Youth Participatory Action Research (YPAR) proposal will improve knowledge and awareness of the health impacts of air pollution exposure, will elevate the youth voice, improve youth self-efficacy…
- Trial name
- NCT06322966
- Testing
- Air Action Curriculum
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pediatric Obesity, Inhibition
Brain Mechanisms of Overeating in Children
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical…
- Conditions
- Pediatric Obesity, Inhibition, Decision Making, fMRI
- Trial name
- RO1 (NCT03341247)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Penn State University
Mental Health, Conflict
The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
- Trial name
- NCT04980794
- Testing
- Parent-child intervention, Self-study Intervention
- Where
- 3 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Self Efficacy, Mental Health Wellness 1
Leaving Care - a Comparison Study of Implementation, Change Mechanisms, and Effects of Transition Services for Youth Leaving Out-of-home Care
The purpose of this project is to increase understanding of the development, implementation and effectiveness of interventions for young people transitioning from societal care to independent living.
- Conditions
- Self Efficacy, Mental Health Wellness 1, Help-Seeking Behavior, Frustration
- Trial name
- NCT05813197
- Testing
- My Choice - My Way!, Usual services
- Where
- Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Jonkoping University
Executive Dysfunction, Autism Spectrum Disorder
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD
This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation…
- Conditions
- Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
- Trial name
- NCT05131659
- Testing
- Executive function group therapy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Autism Spectrum Disorder, Mental Disorders
Physiological Mechanisms of Therapeutic Horseback Riding Intervention Effects in a Psychiatric Population of ASD Youth
This randomized control trial (RCT) seeks to assess the mechanisms underlying Therapeutic Horseback Riding's (THR) previously observed significant positive effects on ASD youth, particularly those with co-occurring psychiatric…
- Trial name
- NCT04606966
- Testing
- Therapeutic Horseback Riding, Barn Activity, Hybrid
- Where
- 2 sites in United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Health Behavior
The Together on Diabetes Intervention - a Realist Evaluation
The Danish healthcare system is universal and free of charge for Danish citizens, as all healthcare services are financed by general taxes.
- Conditions
- Type 2 Diabetes Mellitus, Health Behavior, Delivery of Health Care
- Trial name
- NCT04722289
- Testing
- Together on Diabetes
- Volunteers
- 20 people
- Sponsor
- Center for Diabetes, Copenhagen Municipality
Anxiety Disorders, Depressive Disorder
Big Feelings: A Study on Children's Emotions in Therapy
The goal of this clinical trial is to learn about how psychotherapy works for children and adolescents aged 8 - 15 with anxiety, depression, trauma, or disruptive behaviour.
- Conditions
- Anxiety Disorders, Depressive Disorder, Mood Disorders, Conduct Disorder
- Trial name
- NCT05637320
- Testing
- Modular Approach to Therapy for Children with Anxiety, Depression, Trauma or Conduct Problems
- Where
- 2 sites in Canada
- Volunteers
- 202 people
- Sponsor
- University of Guelph
Chronic Widespread Pain, Stress, Psychological
Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment.
- Conditions
- Chronic Widespread Pain, Stress, Psychological, Stress, Physiological
- Trial name
- NCT04488757
- Testing
- functional Magnetic Resonance Imaging (fMRI), Allostatic Load Composite
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Child Behavior Problem
Effectiveness of the Social-Emotional Prevention Program Enhanced Version
The current study is intended to investigate the effectiveness of the Social-Emotional Prevention Program enhanced version (SEP+) for increasing preschoolers' social-emotional competencies and reducing their risk for behavior…
- Trial name
- SEP+ (NCT05057728)
- Testing
- Social-Emotional Prevention Program enhanced version
- Where
- Romania
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Anxiety Disorders, Social Anxiety Disorder
Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing Problems
To investigate the efficacy and mechanisms of change of an Internet-delivered transdiagnostic REBT intervention for adolescents with internalizing problems.
- Conditions
- Anxiety Disorders, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- REBTonAd (NCT04179526)
- Testing
- Transdiagnostic Internet-delivered REBT
- Where
- Romania
- Volunteers
- 106 people
- Sponsor
- Babes-Bolyai University
Child Abuse, Self-control
Coaching Alternative Parenting Strategies (CAPS) Study
This is a randomized, controlled trial (RCT) of Parent-Child Interaction Therapy (PCIT) designed to test the effects of PCIT on self-regulation and behavior in child maltreating (CM) parents and their elementary-school children.
- Conditions
- Child Abuse, Self-control, Parenting
- Trial name
- CAPS (NCT02684903)
- Testing
- Parent Child Interaction Therapy
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- University of Oregon
Rural Left-Behind Children, Social Adaptation
Music Therapy for Character Development and Social Adaptation Among Rural Left-Behind Children
Rural left-behind children (LBC) are children in rural China whose parents have migrated to cities for work. They often face emotional and social difficulties because of long-term separation from parents.
- Conditions
- Rural Left-Behind Children, Social Adaptation, Character Development
- Trial name
- MT-LBCCDSA (NCT07877961)
- Testing
- Group Music Therapy, Psychoeducational Lectures
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shangqiu Normal University
Alcohol Drinking
Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms
This study will help to determine whether the medication, topiramate, reduces alcohol use among adolescents with alcohol dependence.
- Trial name
- IMPACT (NCT01641445)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University