Clinical trials: Block
Adolescent Idiopathic Scoliosis, Juvenile Idiopathic Scoliosis
IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction
The goal of this pilot study is to assess the feasibility of conducting a randomized controlled trial at a single institution comparing erector spinae plane blockade (ESPB) with liposomal bupivacaine (LB, Exparel) to intravenous…
- Trial name
- AIMS (NCT05730920)
- Testing
- Methadone, Liposomal bupivacaine (LB, Exparel)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dr. Casey Stondell, MD
Hip Surgery Corrective, Anesthesia; Functional
Effectiveness of Fascia Iliaca Nerve Block for Post Hip Arthroscopy
There is currently no standard of care or best practice for managing post-operative pain for patients undergoing hip arthroscopy. Perioperative pain with these procedures can be substantial.
- Trial name
- NCT02717728
- Testing
- Drug group Fascia iliaca nerve block
- Where
- United States
- Sponsor
- Boston Children's Hospital
Pain, Postoperative
Spinal Versus Caudal Analgesia After Pediatric Infra-umbilical Surgery
Caudal analgesia along with general anesthesia is a very popular regional technique for prolonged postoperative analgesia in different pediatric surgical procedures where the surgical site is sub-umbilical.
- Trial name
- ITVSEpidural (NCT02988700)
- Testing
- Intrathecal hyperbaric bupivacaine 0.25mg/kg 0.5%, caudal plain bupivacaine 2.5mg/kg 0.25%
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Renal Cell Carcinoma, Urothelial Carcinoma
Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
This is a comparative study using resected/ biopsied tumors samples collected from renal cell carcinoma and urothelial carcinoma patients who underwent surgical removal of lesions, followed by immune checkpoint blockade (ICB)…
- Conditions
- Renal Cell Carcinoma, Urothelial Carcinoma, Bladder Cancer, Ureter Cancer
- Trial name
- NCT03291028
- Testing
- Immune checkpoint inhibitor targeting PD1
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Fox Chase Cancer Center
Uretro-pelvic Junction Obstruction, Poorly Function Kidney
Laparoscopic Assisted Dismembered Pyeloplasty Versus Open Pyeloplasty in (UPJO) With Poorly Function Kidney in Pediatrics
The management of kidneys with poor function less than 10% has been the subject of debate for more than a decade. Some authors have recommended nephrectomy while others favor renal salvage (pyeloplasty).
- Trial name
- NCT05953571
- Testing
- Dismembered Pyeloplasty
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Al-Azhar University
Orchiopexy, Inguinal Hernioplasty
Ultrasonographic Assessment of Optic Nerve Sheath Diameter in Children Receiving Caudal Block
The recent study revealed that high-volume caudal block caused reduction in cerebral blood flow velocity and cerebral oxygenation. It was supposed to be associated with increased intracranial pressure.
- Conditions
- Orchiopexy, Inguinal Hernioplasty, Hydrocelectomy, Diverticulectomy
- Trial name
- NCT02768493
- Testing
- 1.0 ml/kg of 0.15% ropivacaine, 1.5 ml/kg of 0.15% ropivacaine
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Hypertension, Portal, Interventional Radiology
Percutaneous Portal Vein Recanalization for Refractory Portal Hypertension in Children With Non-Cirrhotic Extrahepatic Portal Vein Obstruction
This monocentric, prospective, observational study aims to evaluate the clinical efficacy, safety, and technical success of percutaneous portal vein recanalization (PVR) performed via interventional radiology.
- Conditions
- Hypertension, Portal, Interventional Radiology, Percutaneous Portal Vein Recanalization (PVR), Extrahepatic Portal Vein Obstruction (EHPVO)
- Trial name
- PRIMO-01 (NCT07873021)
- Testing
- Percutaneous Portal Vein Recanalization (PVR)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Papa Giovanni XXIII Hospital
Anesthesia
Trans-incisional Quadratus Lumborum Block Versus Caudal Analgesia in Pediatric Open Renal Surgeries.
There is scare literature about the usage of QLB in pediatric population, particularly the trans-incisional approach. Hence, the purpose of this study is to compare the postoperative analgesic efficacy of ultrasound-guided caudal…
- Trial name
- NCT04790318
- Testing
- Trans-incisional Quadratus lumborum block, Caudal block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Aortic Valve Stenosis
Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease
The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification.
- Trial name
- NCT01939678
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Region Örebro County
Malaria, Falciparum
Mass-Drug Administration to Reduce Malaria Transmission
In the 1950s, the WHO included mass drug administration (MDA) with antimalarial drugs as a tool for malaria control in 'exceptional conditions when conventional control strategies have failed'.
- Trial name
- MDATRANS (NCT00509015)
- Testing
- Sulphadoxine-pyrimethamine (day 1: 500mg S&25mg P/20 kg), Artesunate (day 1,2,3: 4 mg/kg), Primaquine-base (day 3: 0.75 mg/kg)
- Where
- Tanzania
- Volunteers
- 6,000 people
- Sponsor
- Radboud University Medical Center
Class II Malocclusion
Conventional Versus 3D Printed Twin Block Appliances in Growth Modification of Class II Malocclusion
The present study was conducted to evaluate the outcomes of conventionl versus 3D printed twin block appliances in growth modification of class II malocclusion (comparative clinical study) in both groups.
- Trial name
- RCT (NCT07792525)
- Testing
- Twin Block
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Hyperopia
Effect of Light-Blocking Lenses on Pediatric Hyperopia
This study aims to assess the efficacy of light-blocking lenses in facilitating emmetropization in children with hyperopia and to explore their influence on various aspects of visual function.
- Trial name
- NCT07142915
- Testing
- light-blocking lenses, single-vision lenses
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
ACL Tear, Opioid Misuse
Exparel vs. ACB With Bupivacaine for ACL Reconstruction
Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. Post-surgical opioid prescriptions for commonly performed surgeries such as anterior cruciate ligament reconstruction (ACLR)…
- Conditions
- ACL Tear, Opioid Misuse, Pain, Anxiety
- Trial name
- NCT06274008
- Testing
- Exparel
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Hypoxemia
Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX)
The prevention of the occurrence of respiratory events is a constant concern in pediatric anesthesia, as these represent the main cause of the anesthesic mortality.
- Trial name
- ROC-HYPOX (NCT02589691)
- Testing
- Rocuronium, Sodium chloride 0.9%
- Where
- 6 sites in France
- Volunteers
- 412 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Palatal Expansion Technique
Investigation of Skeletally Anchored Expansion of the Maxilla
This study aims to compare two different methods for maxillary expansion in adult patients with transverse maxillary deficiency. Participants will receive either miniscrew-assisted rapid palatal expansion (MARPE-MICRO-4).
- Trial name
- NCT07383376
- Testing
- MARPE, SARME
- Where
- Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Regional Anesthesia, Postoperative Pain
Pudendal Block Versus Penian Block For Circumcision In Children
The authors study the efficacy of the pudendal versus penile block for the relief of postoperative pain in children receiving ambulatory circumcision.
- Conditions
- Regional Anesthesia, Postoperative Pain, Circumcision
- Trial name
- NCT03046290
- Testing
- circumcision, Lidocaine, Ropivacaine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Université Libre de Bruxelles
Lower Urinary Tract Obstructive Syndrome
Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions
There are two options of fetal treatment in cases of severe lower urinary tract obstructions: the vesico-amniotic shunting and fetal cystoscopy.
- Trial name
- CYSTUO (NCT01552824)
- Testing
- CYSTO, Vesico-amniotic shunt
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Aortic Stenosis, Severe
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects with symptomatic, severe, calcific aortic stenosis (AS).
- Trial name
- NCT05172960
- Testing
- SAPIEN X4 THV, SAPIEN X4S
- Where
- 65 sites in United States, Australia and 2 more
- Volunteers
- 1,234 people
- Sponsor
- Edwards Lifesciences
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
Post Operative Pain
Pectointercostal Block for Postoperative Pain Management After Sternotomy
This randomized, controlled study is designed to assess the quality of analgesia provided by ultrasound-guided bilateral pectointercostal facial block in children undergoing cardiac surgery via midline sternotomy.
- Trial name
- NCT05552417
- Testing
- Pectointercostal facial plan block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
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