Clinical trials: Bowel Dysfunction
Digestive System Disease
Epidemiological Screening of IL10RA Mutation Rate in China
The presentation of IBD in early childhood is uncommon and the monogenetic defects, especially IL-10 signaling pathway play a key role in very early onset inflammatory bowel disease (VEO-IBD).
- Trial name
- Yes (NCT03097731)
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Inflammatory Bowel Disease
Resistance Training Intervention to Promote Lean Mass in Youth With IBD
Evaluate feasibility, safety, and preliminary estimates of resistance training (RT) efficacy to promote lean body mass accrual in patients with CD aged 14-18.
- Trial name
- NCT04017637
- Testing
- Resistance Training
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Colorectal Cancer
Curative Proton Beam Therapy for Patients With Lung Metastasis of Colorectal Cancer
Proton alone therapy is performed -> 5 times a week, 7200 cGy / 15 fractions for 3 weeks total
- Trial name
- NCT03566355
- Testing
- curative proton therapy
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- National Cancer Center, Korea
Colorectal Cancer
A Study of Avastin With Chemotherapy for Treatment of Metastatic or Advanced and Unresectable Colorectal Adenocarcinoma
This is an observational study designed to follow patients with metastatic or locally advanced and unresectable colorectal cancer who are receiving Avastin in combination with chemotherapy and whose cancer has been either…
- Trial name
- NCT00097578
- Where
- United States
- Volunteers
- 1,953 people
- Sponsor
- Genentech, Inc.
Inflammatory Bowel Diseases
Markers of Oxidative Stress in Inflammatory Bowel Diseases: Risk Factors and Implications for a Dietetic Approach
Inflammatory bowel disease (IBD), including Crohn's disease (CD), Ulcerative Colitis (UC) and IBD-unclassified (IBD-U) is a chronic inflammatory intestinal disorders that affect both children and adults.
- Trial name
- OxIBDiet (NCT04513015)
- Testing
- Antioxidant diet, Normal dietetic scheme
- Where
- 2 sites in Italy
- Volunteers
- 155 people
- Sponsor
- Università Politecnica delle Marche
Crohn's Disease, Recurrence
Crohn's Extent of Resection Trial
The trial will investigate if removing an additional length of small bowel will result in lower risk of recurrence at the surgical join (anastomosis), thereby decreasing the need for further surgery in the future.
- Trial name
- CERT (NCT01876264)
- Testing
- Extended resection, Conventional resection
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Inflammatory Bowel Disease, Crohn Disease
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy
The investigators will be administering oral high dose interval vitamin D, concurrently when participants are receiving biologic therapy for their inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Vitamin D Deficiency
- Trial name
- NCT04331639
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Bladder and Bowel Dysfunction
Bladder and Bowel Dysfunction in Children
Background: Bladder and bowel dysfunction (BBD) is characterized by lower urinary tract symptoms accompanied by bowel complaints. BBD is a common condition in childhood.
- Trial name
- NCT05318365
- Testing
- Polyethylene Glycol 3350, Urotherapy
- Where
- 3 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Appendicitis
IA Model for Acute Appendicitis in CT
the investigators's study group has developed a fully automated 3D convolutional neural network (CNN)-based diagnostic framework using information of appendix (IA) model to identify non-appendicitis and simple and complicated…
- Trial name
- NCT06175169
- Testing
- Information of Appendix (IA) model
- Where
- South Korea
- Volunteers
- 568 people
- Sponsor
- Hallym University Medical Center
Crohn's Disease
An Efficacy and Safety Study of Omega-3 Free Fatty Acids (Epanova™) for the Maintenance of Symptomatic Remission in Subjects With Crohn's Disease
The purpose of this study is to see if Epanova™ is able to maintain the symptomatic remission in subjects with Crohn's Disease who are responding to steroid induction therapy.
- Trial name
- NCT00074542
- Testing
- Epanova™ (Omega-3 Free Fatty Acids)
- Where
- 31 sites in United States, Canada
- Volunteers
- 364 people
- Sponsor
- Tillotts Pharma AG
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Colorectal Neoplasms Malignant
Significance of Benign Lymph Node Enlargement in Colorectal Cancer
The objective of this observational study was to investigate the clinical significance of benign mesenteric lymph node （BLNE） enlargement in patients with colorectal cancer.
- Trial name
- NCT06410729
- Testing
- Observational study, no intervention
- Volunteers
- 2,270 people
- Sponsor
- Peking University Third Hospital
Intestinal Diseases, Parasitic
Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Women of reproductive age are considered a high-risk group for worm infections by the World Health Organization. Maternal infection and anemia contribute to infant malnutrition by affecting milk quality and quantity, and duration…
- Trial name
- NCT01748929
- Testing
- Albendazole
- Where
- Peru
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Gangrenous Appendicitis
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis
A prospective, randomized controlled clinical trial was conducted at the Hospital Universitario de Santander to test the effectiveness of providing a single 1-dose therapy of antibiotic prophylaxis versus a 5-day antibiotic…
- Trial name
- NCT01115153
- Testing
- prophylaxis, therapy
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Universidad Industrial de Santander
Leukemia, Inborn Errors of Metabolism
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT).
- Conditions
- Leukemia, Inborn Errors of Metabolism, Bone Marrow Failure Syndromes, Immunodeficiencies
- Trial name
- ExpMACs (NCT02356653)
- Testing
- Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Philadelphia
Rectal Cancer, Obesity
Does Obesity Increase the Risk of Conversion and Short Term Complications in Laparoscopic Rectal Surgery?
Obesity is on the rise in the Western population and BMI has been shown to be associated with an increased risk of per- and postoperative complications.
- Trial name
- NCT02153853
- Where
- Denmark
- Volunteers
- 335 people
- Sponsor
- Hvidovre University Hospital
Hepatosplenic T-Cell Lymphoma
A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL)
This study is designed to collect tissue samples from the biopsy specimen that was used to diagnose hepatosplenic T-cell lymphoma (HSTCL), additional patient information, and if possible, to obtain additional samples including a…
- Trial name
- NCT01804166
- Testing
- Infliximab, Golimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Janssen Scientific Affairs, LLC
Colorectal Cancer, Metastasis
Trial Comparing Two Strategies of Chemotherapy for Metastatic Colorectal Cancer
The standard treatment of metastatic colorectal cancer is based on systemic chemotherapy. Several effective drugs are currently available and can be administered either sequentially or in combination.
- Trial name
- NCT00126256
- Testing
- 5-fluorouracil, leucovorin, irinotecan
- Where
- France
- Volunteers
- 570 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Appendicitis
Geographic Influences on Appendicectomy Outcomes
Introduction Appendicitis is a common condition which represents a significant resource burden for the Scottish National Health Service (NHS).
- Trial name
- NCT02017951
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Colon Cancer
Specific Training After Stoma Surgery
In Sweden, approximately 43,000 people have undergone surgery with ileo-, colo- or urostomy. The most common type of stomy is a sigmoidostomy.
- Trial name
- STASS (NCT04701853)
- Testing
- Specific abdominal muscle training, Usual care
- Where
- 4 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Göteborg University
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