Clinical trials: Bowel Dysfunction
Appendicitis
Appendicitis During the National Lockdown During the COVID-19 Pandemic
The study aims to examine whether a nationwide lock-down with an entire population subjugated to social distancing reduces the incidence of appendicitis.
- Trial name
- NCT04407117
- Testing
- Lock-down and social distancing
- Where
- Denmark
- Volunteers
- 6,000,000 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Failure to Thrive, Nutritional Deficiency
Nasogastric Tube Securement Comparison Study
This study evaluates the use of tape to secure nasogastric tubes compared to securement with a nasal bridle device.
- Conditions
- Failure to Thrive, Nutritional Deficiency, Constipation, Bowel Obstruction
- Trial name
- NTSNB (NCT03202576)
- Testing
- Nasal Bridle
- Volunteers
- 43 people
- Sponsor
- University of Colorado, Denver
Functional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders
i-CBT Functional Gastrointestinal Disorders in Youth: the Impact of Negative Illness Understanding and Parental Illness Worries
The aim of the current study, embedded in The Danish FGID Treatment Study, is to test Danish versions of Swedish i-CBT programs for children and adolescents with FGID in a Danish clinical context and to further evaluate the…
- Conditions
- Functional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
- Trial name
- NCT05486585
- Testing
- Internet delivered cognitive behavioural therapy for functional gastrointestinal disorders
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Constipation, Fecal Incontinence
Development of an Instrument to Measure Quality of Life in Children With Chronic Constipation and Soiling
We propose to develop parent and child disease-specific instruments to assess health related quality of life (HRQoL) in children with constipation and fecal incontinence.
- Trial name
- NCT00677508
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Medical College of Wisconsin
Surgery
Acute Appendicitis in Foreign Workers of Northern Israel
To Compare the outcome to acute appendicitis in foreign workers to the native patients.
- Trial name
- NCT04895163
- Testing
- Laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 117 people
- Sponsor
- HaEmek Medical Center, Israel
Adenomatous Polyposis Coli
Post-Trial Access for Guselkumab in Participants With Familial Adenomatous Polyposis
The purpose of this post-trial access (PTA) program is to provide guselkumab to participants with Familial Adenomatous Polyposis (FAP) who are experiencing clinical benefit after completing 48 weeks of treatment in Study…
- Trial name
- NCT04948398
- Testing
- Guselkumab
- Sponsor
- Janssen Research & Development, LLC
Abdominal Pain, Irritable Bowel Syndrome
Pain Processing and Pain Neuroscience Education in Children With Chronic Abdominal Pain
The primary scientific objective of the study entails examining whether altered endogenous pain inhibition is present in children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS) compared with healthy…
- Trial name
- NCT02880332
- Testing
- Usual care, Pain Neuroscience education, Extra care
- Where
- Belgium
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Enteropathy, Necrotizing Enterocolitis
Use of Faecal Calprotectin to Predict Enteropathy of the Preterm Neonates
This study aims to evaluate a clinico-biological predictive score, associating the faecal calprotectin, for the diagnosis of enterocolitis and enteropathy of the preterm neonates.
- Trial name
- CALPROPREMA (NCT02010268)
- Testing
- Collection of stool samples
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitamin D on Tumor Response and Inflammatory Markers, Colo-rectal Cancer
Evaluation the of Role of Vitamin D Supplement on Tumor Response, Inflammation and Apoptosis in Patients With Stage II or III Colorectal Cancer Receiving Chemotherapy.
The aim of this work is to assess the of role of Vitamin D supplement on tumor response, inflammation and apoptosis in patients with stage II or III colorectal cancer receiving chemotherapy using BAX protein and Tumor necrosis…
- Trial name
- NCT07241247
- Testing
- Vitamin D
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tanta University
Celiac Disease
Gluten-free Diet Monitoring in Urine
The purpose of this study is to develope a novel method to determine gluten intake and to check gluten-free diet adherence in celiac patients by detection of gluten immunogenic peptides in urine.
- Trial name
- NCT02344758
- Testing
- Non-invasive lateral flow test for monitoring gluten intake, gluten-free diet (GFD), gluten-containing diet
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- University of Seville
Diarrhea Infectious, Shigella
The Impact of Shigellosis and Recommended Treatment in Children
The purpose of this study is to evaluate whether antibiotic treatment of non-dysentery Shigella associated watery diarrhea (NDSD) cases improves clinical outcomes and growth in children.
- Conditions
- Diarrhea Infectious, Shigella, Growth & Development
- Trial name
- TrtNDSD (NCT07433426)
- Testing
- Azithromycin
- Where
- 4 sites in Bangladesh, Zambia
- Volunteers
- 700 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Ulcerative Colitis
Effect and Mechanism of Baitouweng Decoction for Large Intestine Damp-heat Syndrome of Ulcerative Colitis
Baitouweng Decoction is traditionally used to treat large intestine damp-heat syndrome of ulcerative colitis (UC) by oral administration and rectal enema.The project applicant's invention of transendoscopic entral tubing (TET)…
- Trial name
- NCT06421818
- Testing
- Baitouweng Tang
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Acute Appendicitis, Acute Appendicitis With Rupture
Prioritisation of Acute Appendicitis Using Appendistat Score
Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment.
- Trial name
- APEX (NCT07197489)
- Where
- 2 sites in United Kingdom
- Volunteers
- 592 people
- Sponsor
- University College, London
Giardiasis
Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh
This longitudinal study aimed to assess whether regular anti-Giardia and antihelmintic treatment improved growth and small intestinal mucosal function of rural Bangladeshi infants.
- Trial name
- NCT00607074
- Testing
- Anti-Giardia and antihelmintic treatment (secnidazole or albendazole), Anti-Giardia treatment only (secnidazole or albendazole)
- Where
- Bangladesh
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Neonatal SEPSIS, Necrotizing Enterocolitis
A Panel of Biomarkers in Diagnosing Late-onset Neonatal Sepsis and Necrotizing Enterocolitis in Sibu Hospital
This is a cross-sectional study to evaluate the utilities of a panel of biomarkers (Procalcitonin, Interleukin-6, Serum Amyloid A and Apolipoprotein C2) versus the gold standard blood culture result diagnosing late-onset neonatal…
- Trial name
- PISALONS (NCT03578978)
- Testing
- No intervention
- Where
- 2 sites in Malaysia
- Volunteers
- 200 people
- Sponsor
- Clinical Research Centre, Malaysia
Appendicitis, Gastroenteritis
Study on the Difference of Axilo-rectal Temperature in Appendicitis
The investigators are studying prospectively the difference in axilo-rectal temperature in patients with acute appendicitis and using as a control group patients consulting with acute gastroenteritis at our emergency unit.
- Trial name
- NCT00674726
- Testing
- Observation and measurement of axilo-rectal temperature
- Where
- 2 sites in Chile
- Sponsor
- Cirujanos la Serena
Gastro-Intestinal Disorder
Advanced GastroInstestinal(GI) Surgery Training in Residency and Fellowship.
The aim of this anonymous survey is to identify who teaches GI procedures to general surgical residents during residency training and understand the need as well as desire for an Advanced Surgical GI fellowship amongst senior…
- Trial name
- NCT07494318
- Testing
- Advanced GI Surgery Training
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Methodist Health System
Ulcerative Colitis, Ulcerative Colitis Chronic
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD).
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
- Trial name
- SHINE-ON (NCT04844606)
- Testing
- Mirikizumab
- Where
- 69 sites in United States, Austria and 14 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Colitis, Ulcerative
A Study of Ustekinumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The purpose of this study is to evaluate: a) the efficacy of ustekinumab dosing in inducing clinical remission, b) safety profile of ustekinumab, and c) ustekinumab exposure (pharmacokinetics [PK]) in pediatric participants with…
- Trial name
- UNIFI Jr (NCT04630028)
- Testing
- Ustekinumab Dose Based on BSA and Body Weight
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 112 people
- Sponsor
- Janssen Research & Development, LLC
Total Colonic Aganglionosis, Hirschsprung Disease
Robot/Laparoscopic-Assisted Transanal Transection Duhamel Versus Modified Soave Pull-Through for TCA
Total colonic Hirschsprung disease (TCA) is the most severe form of Hirschsprung disease and is commonly managed with neonatal enterostomy followed by delayed definitive pull-through.
- Conditions
- Total Colonic Aganglionosis, Hirschsprung Disease, Duhamel, Soave
- Trial name
- NCT07343622
- Testing
- Transanal Transection Duhamel operation, Modified Soave Pull-Through
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zunyi Medical College
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