Clinical trials: Bronchial Hyperresponsiveness
Asthma, Lung Diseases
Genetics of Asthma and Bronchial Hyperresponsiveness
To investigate the genetics of asthma by reexamining a carefully characterized population of patients with asthma, and by studying their families.
- Trial name
- NCT00005359
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Sensitivity and Specificity of Aridol Challenge for a Diagnosis of Asthma by a Specialist Pulmonologist
The purpose of this study is to estimate the sensitivity, specificity and positive and negative predictive values of a positive Aridol challenge with respect to a specialist pulmonologist diagnosis of asthma in corticosteroid…
- Trial name
- NCT00491153
- Where
- 3 sites in Norway
- Volunteers
- 35 people
- Sponsor
- St. Olavs Hospital
Asthma, Bronchial Hyperresponsiveness
The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Respiratory diseases including Asthma are high prevalent among preschool children. Specific treatment, nowadays, include steroid inhalers and anti leukotrienes.
- Trial name
- NCT01006655
- Testing
- Beclomethasone dipropionate HFA
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Rambam Health Care Campus
Bronchial Hyperreactivity, Bronchial Asthma
Comparison of Two Methods of Bronchial Methacholine Provocation
This study is meant to compare two routine diagnostic approaches in patients with bronchial asthma. Patients are challenged with methacholine in order to measure their bronchial response.
- Trial name
- NCT00503659
- Testing
- Bronchial methacholine provocation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma, Airway Hyperresponsiveness
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are…
- Trial name
- proto nage (NCT00686452)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Asthma in Children
Adjustment of Asthma Treatment in Children Based on an Indirect Hyperresponsiveness Test
The aim of the study is to assess the usefulness of the indirect bronchial hyperresponsiveness test (with hypertonic NaCl) in determining the optimal dose of inhaled steroids to maintain asthma control.
- Trial name
- NCT04509921
- Testing
- asthma treatment adjustment taking account on degree of bronchial hyperresponsiveness
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
House Dust Mite Allergy, Bronchial Hyperresponsiveness
Safety of Bronchial Allergen Challenge and Predictors for Positive Reaction.
The present study is aimed to evaluate a bronchial allergen challenge with house dust mite and alternaria. Firstly, the years 2005, 2006, 2007, 2008 and 2009 will be retrospectively reviewed.
- Trial name
- NCT01134757
- Testing
- house dust mite and alternaria allergen bronchial challenge
- Where
- Germany
- Volunteers
- 425 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bronchial Hyperreactivity, Hypersensitivity
Influence of Nutrition on Nasal and Bronchial Affliction in Patients With Allergy on Grass-Pollen
The study is meant to observe the influence of nutrition on nasal and bronchial discomfort in patients with allergy on grass pollen after specific bronchial provocation.
- Conditions
- Bronchial Hyperreactivity, Hypersensitivity, Allergy, Bronchial Asthma
- Trial name
- NCT00519740
- Testing
- inhalative specific bronchial provocation with grass-pollen
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma Chronic
Inflammatory Indices in Predicting the Failure of Inhaled Corticosteroids Reduction in Young Participants With Asthma
A prospective, observational, interventional, single-blind study (blinded for a clinician in the field of inflammatory parameters).
- Trial name
- NCT03788057
- Testing
- ICS dose reduction
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Asthma
Asthma and Allergy Screening AA2000 (Cross Sectional)
Asthma screening of 493 asthma patients
- Trial name
- AA2000 (NCT04727112)
- Testing
- Usual care versus primary care
- Volunteers
- 493 people
- Sponsor
- Bispebjerg Hospital
Allergic Rhinitis
Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic Disease
Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups: 1.
- Trial name
- NCT00569361
- Testing
- Collection of nasal epithelial cells
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Bronchial Hyperreactivity
Different End Points for Bronchial Hyperactivity (BHR) Tests.
Bronchial challenge tests (BCT) are being used to diagnose bronchial hyperactivity (BHR) and quantify its severity.In older children and adults, BCT is done using spirometry to measure the value of 20% fall in FEV1 as an…
- Trial name
- NCT01654588
- Where
- Israel
- Volunteers
- 501 people
- Sponsor
- Wolfson Medical Center
Asthma
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers.
The prevalence of airway hyperresponsiveness (AHR) is very high in elite swimmers, reaching 80% in certain studies. Repeated Chlorine-derivatives exposure may be a major causative factor for its development.
- Trial name
- NCT00876135
- Testing
- Ventolin
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Laval University
Primary Ciliary Dyskinesia, Healthy
Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia
The purpose of this study is to look at children with PCD and see if they have another condition called "bronchial hyperresponsiveness".
- Trial name
- BHR (NCT07288827)
- Testing
- Lung Function Testing, Phlebotomy, Allergy skin prick testing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma
Treatment Of Symptomatic Asthma In Children
This study is being conducted to investigate whether in childhood salmeterol/ fluticasone propionate 50/100 bd delivered via the Diskus® inhaler and fluticasone propionate 200 mcg bd delivered via the Diskus® inhaler are non…
- Trial name
- NCT00197106
- Testing
- Salmeterol/ fluticasone propionate Diskus® inhaler 50/100 mcg, fluticasone propionate 2 x 100 mcg
- Where
- 18 sites in Netherlands
- Volunteers
- 176 people
- Sponsor
- GlaxoSmithKline
Asthma
GSK BHR Study (Sont)
The purpose of this study was to determine whether asthma control and reduced bronchial hyperresponsiveness could be achieved and maintained at a lower dose of inhaled corticosteroids with ADVAIR DISKUS twice-daily or FP…
- Trial name
- NCT00920543
- Testing
- FP 100mcg, FP 500mcg, FP 250mcg
- Where
- 58 sites in United States, Brazil and 2 more
- Volunteers
- 464 people
- Sponsor
- GlaxoSmithKline
Asthma
Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics
This is a Phase 3 study to determine the sensitivity and specificity of the Aridol bronchial challenge test to detect bronchial hyperresponsiveness in patients with suspected asthma.
- Trial name
- NCT00252291
- Testing
- Aridol, Methacholine, Exercise challenge
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Syntara
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Asthma
Pediatric Asthma Study Using Stepwise Treatment With Two Food And Drug Administration Approved Asthma Medications
This study was designed to evaluate if, in children with asthma, a stepwise treatment (five levels varying from once daily fluticasone propionate 100mcg until twice daily a fixed combination of salmeterol and fluticasone…
- Trial name
- NCT00158834
- Testing
- Salmeterol/Fluticasone propionate combination product, Fluticasone propionate
- Where
- 16 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- GlaxoSmithKline