Clinical trials: Cancer Patients and Physical Activity
Locally Advanced Solid Tumors, Metastatic Solid Tumors
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult…
- Trial name
- TRIDENT-1 (NCT03093116)
- Testing
- Oral repotrectinib (TPX-0005)
- Where
- 165 sites in United States, Australia and 17 more
- Volunteers
- 500 people
- Sponsor
- Turning Point Therapeutics, Inc.
Acute Myeloid Leukemia (AML)
Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants of Any Age With Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) is an aggressive and rare cancer of myeloid cells (a white blood cell responsible for fighting infections) and is the most common acute leukemia in adults.
- Trial name
- NCT04813263
- Where
- 281 sites in Japan
- Volunteers
- 424 people
- Sponsor
- AbbVie
Thyroid Cancer
The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients
This study will examine whether and how levothyroxine (Synthroid, a synthetic thyroid hormone) affects the way the body handles other drugs.
- Trial name
- NCT00080574
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cancer, Pediatric Cancer
Massage Impact on Sleep in Pediatric Oncology
This study aims to determine the impact of massage therapy for pediatric patients receiving intensive chemotherapy or stem cell transplant (SCT).
- Conditions
- Cancer, Pediatric Cancer, Chemotherapy Effect, Acute Myeloid Leukemia
- Trial name
- NCT06892158
- Testing
- Massage therapy, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiovascular Diseases, Cardiovascular Risk Factor
Cooking for Health Optimization With Patients
Cooking for Health Optimization with Patients (CHOP) is the first known multi-site prospective cohort study with a nested Bayesian adaptive randomized trial in the preventive cardiology field of culinary medicine.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Nutrition Disorders, Diabetes
- Trial name
- CHOP (NCT03443635)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 7,192 people, healthy volunteers welcome
- Sponsor
- Tulane University
Quality of Life
Quality of Life in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy
The purpose of the study is to evaluate the impact of exercise on physical activity levels and quality of life in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy.
- Trial name
- NCT03132948
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Connecticut Children's Medical Center
Acute Myeloid Leukemia
A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)
To find a recommended dose of ASTX727 (cedazuridine/decitabine) in combination with venetoclax for pediatric patients with relapsed AML.
- Trial name
- NCT06191978
- Testing
- ASTX727, Venetoclax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Fallopian Tube Cancer, Ovarian Cancer
CA 125 Levels in Treating Patients With Relapsed Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Who Are Receiving Tamoxifen
RATIONALE: Estrogen may cause the growth of ovarian cancer cells. Hormone therapy using tamoxifen may fight ovarian cancer by blocking the use of estrogen by the tumor cells.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00305838
- Testing
- tamoxifen citrate, diagnostic laboratory biomarker analysis
- Where
- 24 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Mount Vernon Cancer Centre at Mount Vernon Hospital
Oropharynx Cancer
Staying Connected: a Mobile Health Study With the Noona® and Mobili-T® Systems
Mobile health applications are an attractive technological solution that facilitates access to care for patients conveniently and efficiently.
- Trial name
- NCT05368025
- Testing
- Mobili-T/Noona
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Chronic Lymphocytic Leukemia, Exercise
Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients
Chronic lymphocytic leukemia (CLL) is a hematological neoplasm that primarily affects older individuals and is the most common type of leukemia in adults in Western countries.
- Trial name
- NCT06654206
- Testing
- Exercise, Home exercise
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Esophageal Cancer
Rehabilitative Strategies Following Oesophageal Cancer
The ReStOre trial is a multi-disciplinary intervention of exercise, diet and education for patients who have completed treatment for oesophageal cancer.
- Trial name
- ReStOre (NCT03314311)
- Testing
- Rehabilitation programme
- Where
- Ireland
- Volunteers
- 44 people
- Sponsor
- University of Dublin, Trinity College
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, Classical Hodgkin Lymphoma
Allogeneic CD30 Chimeric Antigen Receptor Epstein-Barr Virus-Specific T Lymphocytes in Relapsed or Refractory CD30-Positive Lymphomas
This study involved patients that have a cancer called diffuse large B cell lymphoma (DLBCL), NK and T cell lymphomas (NK/TL) or classical Hodgkin lymphoma (cHL) (hereafter these 3 diseases will be referred to as lymphoma).
- Trial name
- NCT04952584
- Testing
- CD30.CAR-EBVST cells
- Where
- 2 sites in United States
- Sponsor
- Baylor College of Medicine
Prostate Cancer
The Physical Exercise and Prostate Cancer Study
The purpose of this study is to determine the effectiveness of a four months strength training program on physical and psychological health in patients with prostate cancer during androgen deprivation therapy.
- Trial name
- PEPC (NCT00658229)
- Testing
- Strength training group
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Advanced Solid Tumor
Study of FCN-011 in Patients With Advanced Solid Tumor（Phase I）and NTRK Fusion Positive Advanced Solid Tumor （Phase II）
A multicenter, open, single-arm phase I dose exploration and phase II extended study was conducted to evaluate the safety, tolerability, pharmacokinetic characteristics, and primary antitumor activity of FCN-011 in patients with…
- Trial name
- NCT04687423
- Testing
- FCN-011
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Fochon Pharmaceuticals, Ltd.
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder
The objective of this study is to evaluate the safety and efficacy of eculizumab in pediatric participants (aged 2 to < 18 years) with relapsing neuromyelitis optica spectrum disorder (NMOSD).
- Trial name
- NCT04155424
- Testing
- Eculizumab
- Where
- 35 sites in United States, Canada and 5 more
- Volunteers
- 5 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Allo Transplantation With Mylotarg, Fludarabine and Melphalan for AML, CML and MDS
The goal of this clinical research study is to find the highest safe dose of Mylotarg that can be combined with chemotherapy in patients receiving allogeneic bone marrow transplantation.
- Conditions
- Acute Myelogenous Leukemia, Myelodysplastic Syndrome, Chronic Lymphocytic Leukemia
- Trial name
- NCT00038831
- Testing
- Mylotarg, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- M.D. Anderson Cancer Center
Pediatric Cancer
Initiation of Adapted Physical Activity for Patients With Advanced Pediatric Malignancies
Adapted physical activity (APA) in the context of cancer is a field of growing interest and has been explored in numerous publications.
- Trial name
- NCT03659968
- Testing
- Physical activity training
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
B Cell Leukemia, B Cell Lymphoma
A Study Evaluating UCART019 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma
Autologous T cells engineered to express chimeric antigen receptors (CARs) against leukemia antigens such as CD19 on B cells have shown promising results for the treatment of relapsed or refractory B-cell malignancies.
- Trial name
- NCT03166878
- Testing
- UCART019
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Cancer
IMPLEMENT - Model Project for Quality-assured Exercise Therapy for Cancer Patients
IMPLEMENT aims to develop, test and establish a sustainable access structure for quality-assured oncological exercise therapy (qOET) in Germany as a model within the funding period of three years.
- Trial name
- NCT06496711
- Testing
- Cancer Patients; Institutions and their employees in the treatment and/or counseling of cancer patients
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Cologne
Advanced Cancer
Yoga for Adolescent and Young Adult Non-Curative Cancer Patients
Adolescents and young adults who are living with cancer are not benefiting from the same age-appropriate physical and psychosocial care, as are children and older adults.
- Trial name
- NCT01901237
- Testing
- Hatha Yoga
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Rob Rutledge