Clinical trials: Cardiovascular Shock
Acute Coronary Syndrome, Recurrent Myocardial Infarction
Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients
This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.
- Conditions
- Acute Coronary Syndrome, Recurrent Myocardial Infarction, Cardiogenic Shock
- Trial name
- NCT03596944
- Testing
- Statin
- Where
- Indonesia
- Volunteers
- 145 people
- Sponsor
- Tarumanagara University
Heart Arrest, Ventricular Fibrillation
AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"
The aim of the trial is to evaluate a new AED algorithm that proposes a new timeline between the time devoted to administer a defibrillation shock, and the time devoted to chest compressions.
- Trial name
- DEFI2005 (NCT00139542)
- Testing
- One shock per minute AED protocol, Guidelines 2000 AED protocol
- Where
- France
- Volunteers
- 5,107 people
- Sponsor
- Fire Brigade Of Paris Emergency Medicine Dept
Shock, Cardiogenic
Impella in Cardiogenic Shock Registry
The purpose of the study is to evaluate the safety, efficacy and clinical usefulness of a mechanical support strategy with the impella device.
- Trial name
- Impella (NCT06007963)
- Testing
- Treatment with impella device.
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiogenic Shock, Cardiac Arrest
China Extracorporeal Life Support Registry
Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective cardiac and respiratory support to patients with lungs and/or heart failure.
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04158479
- Testing
- ECMO
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Anzhen Hospital
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Myocarditis, Myocarditis Acute
Outcome of Clinical Phenotypes of Pediatric Myocarditis at Assiut University Children Hospital
This study aims to investigate the clinical phenotypes, management approaches, and outcomes of myocarditis in children admitted to Assiut University Children's Hospital.
- Trial name
- PED-MYO (NCT07175948)
- Testing
- Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Appropriate and Inappropriate Shock Therapy With ICD, Arrhythmias Detection
Arrhythmias Detection in a Real World Population
The study is a prospective multicenter registry. Consecutive patients with indications of implant / replacement or upgrade of implantable cardioverter defibrillator (ICD) will be enrolled.
- Trial name
- RHYTHM DETECT (NCT02275637)
- Testing
- implantable cardioverter defibrillator
- Where
- 12 sites in Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Coronary Syndrome, Cardiogenic Shock
Outcome of Patients Treated With IABP
Intra-Aortic Balloon Pumps (IABP) is a widely used and effective left ventricular adjuvant therapy. IABP is an inflatable device placed in the aorta that inflates with diastole and deflates with systole.
- Conditions
- Acute Coronary Syndrome, Cardiogenic Shock, Coronary Artery Disease, Heart Failure
- Trial name
- NCT04405856
- Testing
- Intra Aortic Balloon Pump
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing Medical University
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock
Cerebral Autoregulation in Pediatric ECMO (ECMOX 2)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock, Cardiac Arrest
- Trial name
- ECMO-ECMOX2 (NCT04548739)
- Where
- 4 sites in France, Italy
- Volunteers
- 132 people
- Sponsor
- Nantes University Hospital
Intracranial Hypertension, Cerebral Circulatory Failure
Cerebral Compliance Impairment in COVID-19
Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing…
- Trial name
- NCT04429477
- Testing
- Cerebral compliance and hemodynamics monitoring
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Ischemic Stroke, Hemorrhagic Shock
Predictors Of Stroke Outcome In Chidren
Stroke can be defined as an abrupt loss of brain function that is caused by decreased cerebral blood flow. Stroke can occur at all stages of life, but presentation is variable depending on age, involved artery, and underlying…
- Trial name
- NCT04331457
- Testing
- Brain magnetic resonance imaging (MRI) , computed tomography (CT)
- Volunteers
- 30 people
- Sponsor
- Assiut University
Sudden Cardiac Death, Implantable Defibrillator User
S-ICD French Cohort Study (HONEST)
Implantable cardioverter-defibrillators have been proven to be effective in the prevention of sudden cardiac death in high-risk patients.
- Trial name
- HONEST (NCT05302115)
- Testing
- S-ICD
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Paris Sudden Death Expertise Center
Shock, Hypotension and Shock
ClearSight Validation in Pediatrics
Specific aim 1: The specific aim of this study is to compare cardiac output measurements as well as cardiac index, and stroke volume obtained via thermodilution during a cardiac catheterization with data obtained by the…
- Trial name
- NCT03701646
- Testing
- Measurement by Clearsight device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Shock, Cardiogenic, Cardiac Arrest
ECMO LEft Ventricle UNloading Strategy
The present study is an International multicentric prospective observational cohort study. This will be an international research campaign to prospectively collect and analyze clinical data of all VA ECLS patients admitted to…
- Conditions
- Shock, Cardiogenic, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- ECMOLENS (NCT06766006)
- Testing
- Venoarterial extracorporeal life support (VA ECLS) implant
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University