Clinical trials: Cell Invasion
Bladder Cancer
Validation of VI-RADS for the Detection of Detrusor Muscle Invasion
To evaluate the accuracy of Multiparametric MRI in differentiation between invasive and non-invasive bladder cancer using vesical imaging reporting and data system (VI-RADS) score.
- Trial name
- NCT05123404
- Testing
- multi parametric MRI, transurethral resection of bladder tumor
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egyptian Biomedical Research Network
Oral Squamous, Cell Carcinoma
Radio/Pathological Evaluation of Tongue Cancer Infiltration
The aim of the study is to assess the good correlation and prediction of the DOI for the post-operative pathological results and prognosis.
- Trial name
- RaP E ToC (NCT04821128)
- Testing
- Radiologic and pathological review.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Squamous Cell Carcinoma Mouth
Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma
To evaluate the diagnostic accuracy of preoperative MRI in the determination of the primary tumor depth of invasion (DOI) as a predictor factor in neck lymph nodes management in T1T2N0 oral cavity squamous cell carcinomas as…
- Trial name
- NCT07127614
- Testing
- MRI, Histo-Pathological examination of the resected tumor tissues
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Al-Azhar University
Rectal Neoplasms, Prognosis
Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer
Rectal cancer (RC) is among the most prevalent gastrointestinal cancers [1], characterized by significant tumor heterogeneity [2].
- Trial name
- NCT07269912
- Testing
- intravoxel incoherent motion magnetic resonance imaging
- Volunteers
- 400 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Cutaneous Squamous Cell Carcinoma, Bowen's Disease
OCT and Invasion in Cutaneous Skin Lesions
The increasing incidence of actinic keratosis (AK), morbus Bowen (MB) and cutaneous squamous cell carcinoma (cSCC), the patients with often multiple lesions and the disadvantages of invasive diagnostics show the need for an…
- Conditions
- Cutaneous Squamous Cell Carcinoma, Bowen's Disease, Actinic Keratoses, Keratosis, Actinic
- Trial name
- NCT06014697
- Testing
- Optical Coherence Tomography, Clinical assessment
- Where
- Netherlands
- Volunteers
- 71 people
- Sponsor
- Maastricht University Medical Center
Placenta Previa
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
Placenta previa cases are one of the difficult groups of patients to manage in modern obstetrics. When the literature is evaluated extensively, no clear information can be seen especially in terms of hospitalization time.
- Trial name
- NCT04264234
- Testing
- Vaginal Ultrasonography, Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ege University
Surgical Infants Requiring Total Parenteral Nutrition
Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine
We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.
- Trial name
- NCT00647036
- Testing
- Isonitrogenous Vaminolact, Dipeptiven (L-glutamine- Lalanine)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Institute of Child Health
Pancreatic Cancer, Adult, Perineural Invasion
Neutrophil-to-lymphocyte Ratio and CA 19.9 as Predictors of Perineural Invasion in Pancreatic Cancer
Pancreatic cancer has an incidence of 1,401,450 new cases diagnosed annually worldwide and is the third leading cause of cancer-related death in Spain.
- Conditions
- Pancreatic Cancer, Adult, Perineural Invasion, Neutrophil-to-Lymphocyte Ratio, CA 19.9
- Trial name
- NCT06747481
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- University of Las Palmas de Gran Canaria
Bladder Cancer
Validity of Computed Tomography Versus Magnetic Resonance Imaging in Predicting Muscular Invasion of Bladder Cancer
The aim of this work is to compare validity between CT and MRI in detecting muscular invasion in Patients with bladder cancer.
- Trial name
- NCT06046469
- Testing
- CT with contrast, MRI pelvis, TURBT
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Menoufia University
Placenta Accreta
Role of Placental Invasion Index in Decision Making of Placenta Accreta
This study will be conducted on women who have a diagnosis of placenta previ and using ultrasound to make the placenta invasion index and compare the accuracy of the diagnosis during the caesarean section whether it is accreta or…
- Trial name
- NCT05806528
- Testing
- Ultrasound
- Volunteers
- 100 people
- Sponsor
- Sohag University
Urothelial Bladder Carcinoma, Bladder Carcinoma
Tumor Budding and T1 Substaging in Urothelial Bladder Cancer
Bladder cancer is a significant global and local health concern, and predicting how aggressive a patient's tumor will behave is critical for guiding treatment.
- Conditions
- Urothelial Bladder Carcinoma, Bladder Carcinoma, Non-Muscle-Invasive Bladder Cancer (NMIBC), Muscle-Invasive Bladder Cancer (MIBC)
- Trial name
- NCT07529639
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rectal Cancer, Neoplasm Metastasis
A Study of Preoperative Radiation Therapy and Capecitabine in Locally Advanced Rectal Cancer
The purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.
- Trial name
- NCT00122291
- Testing
- Capecitabine, Pelvic radiation
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Alberta Health services
Central Nervous System Embryonal Neoplasm
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Genetic study to learn more about genes involved in the development of central nervous…
- Trial name
- NCT00010114
- Where
- 9 sites in United States
- Volunteers
- 83 people
- Sponsor
- Pediatric Brain Tumor Consortium
GI Cancer
Improving Diagnosis and Treatment for Patients With Rectal Cancer
The cancer stage information from scans guides pre-operative treatment and the type of surgery offered. The investigators are studying whether a new Magnetic Resonance Imaging (MRI) staging method can improve the accuracy of…
- Trial name
- MERCURY 3 (NCT07054047)
- Testing
- mrTDV
- Where
- 3 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- Imperial College London
Rectal Adenocarcinoma
Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
Recent research shows that tumour deposits-small spots of cancer found near the main bowel tumour-may give doctors important information about how aggressive the cancer is and how likely it is to come back.
- Trial name
- RADAR (NCT07345273)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- Imperial College London
Placenta Accrete Spectrum
The Accuracy Of 3D Color Ultrasonography for Detecting the Degree of Placenta Accreta Spectrum Invasion
To evaluate the correlation between preoperative ultrasound imaging findings by 3D Color Doppler Ultrasound and the intraoperative severity of Placenta Accreta Spectrum (PAS) disorders, in order to assess the diagnostic accuracy…
- Trial name
- NCT07250412
- Testing
- Cesarian section
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Bladder Cancer
Optimized Treatment Strategy for HighGrade1 (HGT1) Bladder Cancer Based on Substaging: a Prospective Observational Cohort Study
Non-muscle invasive bladder cancer of High Grade stage T1 (HGT1), has up to 20% risk of progression to invasive disease. Because the depth of substaging seems to identify two separate groups with different progression risk…
- Trial name
- NCT02113501
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hepatocellular Carcinoma, Portal Vein Thrombosis
Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or…
- Conditions
- Hepatocellular Carcinoma, Portal Vein Thrombosis, Hepatic Portal Vein Tumor Invasion
- Trial name
- HSL2012-06 (NCT01690715)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes
Head and Neck Cancer
Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899704
- Testing
- microarray analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Sponsor
- Alliance for Clinical Trials in Oncology
Placenta Accreta Spectrum, Placenta Accreta
Evaluation of Cervical Invasion and Length in Placenta Accreta Patients
Placenta accreta spectrum (PAS), also called morbidly adherent placenta, is a serious pregnancy problem where the placenta attaches too deeply to the uterus wall and does not come out normally after birth.
- Conditions
- Placenta Accreta Spectrum, Placenta Accreta, Placenta Previa
- Trial name
- NCT07452185
- Volunteers
- 200 people
- Sponsor
- Sohag University