Clinical trials: Cerebral Blood Flow
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)
It is a "proof of concept" study, aimed to evaluate whether the "optimal CPP", defined by the best PRx, corresponds to the acceptable CBF values in patients affected by CBF disfunction caused by TBI or SAH.
- Trial name
- NCT00807833
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Infant, Premature, Diseases, Respiratory Tract Diseases
Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates
A randomized controlled clinical trial evaluates cerebral blood flow changes associated with HFOV-VG in comparison to HFOV alone in preterm neonates with respiratory insufficiency during the period of invasive respiratory support
- Conditions
- Infant, Premature, Diseases, Respiratory Tract Diseases, Cerebral Blood Flow
- Trial name
- NCT05592431
- Testing
- High Frequency Oscillatory Ventilation with Volume Guarantee (SLE6000;SLE), High Frequency Oscillatory Ventilation (SLE6000;SLE)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Congenital Heart Disease in Children, Extracorporeal Circulation; Complications
Non-invasive Monitoring of Cerebral Autoregulation in Perioperative Neonatal Cardiac Surgery
Cardiac surgery under extracorporeal circulation (ECC) in newborns with congenital heart disease causes significant morbidity and mortality.
- Trial name
- NEMOCARD (NCT04295239)
- Testing
- MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome
Functional Near-Infrared Spectroscopy (fNIRS) Combined With Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls
Background: Neurocognitive disorders affect how the brain uses oxygen. They may affect mental development in children. These disorders can be studied with imaging scans that use radiation; however, these methods are not ideal for…
- Conditions
- Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome, Creatine Transporter Deficiency, Niemann-Pick Disease Type C1
- Trial name
- NCT05642221
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Healthy Adolescents
Activity Breaks for Brain Health in Adolescents
The main aim for this study is to investigate to what extent physical activity of moderate or low intensity, relative to prolonged inactivity, may acutely alter neural activity-related prefrontal cortex oxygenated hemoglobin…
- Trial name
- ABBaH teens (NCT04552626)
- Testing
- Prolonged sitting (social breaks), Prolonged sitting with step-up exercise break, Prolonged sitting with simple resistance activity breaks
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
High Frequency Oscillation, Volume Targeted Ventilation
Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications.
- Trial name
- NCT06719284
- Testing
- HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order, HFOV at the settings applied prior to the study
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College Hospital NHS Trust
Fabry Disease, Healthy
PET Scans in Normal Volunteers and Patients With Fabry Disease
This study will determine the rate of sugar metabolism in the brain of patients with Fabry disease, a genetic disease of abnormal lipid metabolism.
- Trial name
- NCT00005111
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Anesthesia, General, Infant
Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
- Trial name
- NCT03567031
- Testing
- EtCO2 modification
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Cerebrovascular Circulation, Premature Infants
Automated Adjustment of Inspired Oxygen to Maintaining Regional Cerebral Oxygenation in Preterm Infants on Respiratory Support
Background: fluctuation of cerebral blood flow and oxygenation in neonates who undergo intensive care is an important risk factor for risk of neurodevelopmental impairment.
- Trial name
- NCT02748447
- Testing
- Automated FiO2 adjustment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ASST Fatebenefratelli Sacco
Hemodynamic Monitoring
Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery
Cardiorespiratory changes during lung resection surgery, even though generally well tolerated, may lead to hemodynamic compromise, reducing venous return to the heart and hence cardiac output.
- Trial name
- NCT07808749
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Healthy, Hypercapnia
Role of Prostaglandins in the Regulation of Brain Blood Flow
This study will use magnetic resonance imaging (MRI) to examine the role of prostaglandins-a type of fatty acid with hormone-like actions-in the regulation of brain blood flow.
- Trial name
- NCT00006318
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Traumatic Brain Injury, Intracranial Hypertension
Investigating CBF and ICP Using DCS
We aim to acquire data using DCS on patients who are undergoing invasive ICP and ABP monitoring on ITU as part of their normal treatment. Data will then be correlated to derive various parameters including CBF and BFI.
- Trial name
- ICP-CBF (NCT06039098)
- Testing
- DCS
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Queen Mary University of London
Laparoscopic Surgery
A Comparative Study of Ventilation Strategies in Different Surgical Positions on Intracranial Pressure and Cerebral Blood Flow During Laparoscopic Surgery
The purpose of this clinical trial is to investigate the effects of laparoscopic surgery in the Trendelenburg and Reverse Trendelenburg positions, and variable tidal volume ventilation (V-VCV), pressure-regulated…
- Trial name
- NCT06805747
- Testing
- Variable tidal volume ventilation (V-VCV), Pressure-regulated volume-controlled ventilation (PRVC), Conventional volume-controlled ventilation (C-VCV)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Inner Mongolia Baogang Hospital
Congenital Heart Disease
Cerebral Oximetric Monitoring of the Posterior Circulation
One known risk of pediatric heart surgery is the possibility for brain damage. This problem results from a lack of oxygen rich blood flow to the brain during surgery.
- Trial name
- CerebralOx (NCT00751712)
- Testing
- Cerebral oximeter sensor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Sickle Cell Disease
Measurement of Cerebral Blood Flow Using Transcranial Doppler Ultrasound in Children With Sickle Cell Disease
Sickle cell disease (SCD) affects haemoglobin - the molecule in blood cells which carries oxygen. It causes red blood cells to become abnormal crescent (or sickle)- shaped.
- Trial name
- NCT02090881
- Testing
- Ultrasound scan
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College Healthcare NHS Trust
Altitude Training Adaptation, Cognitive Function
Effects of Bicarbonate Spring Water Immersion on Cognitive Reliability and Post-Maximal Exercise Recovery in Adolescent Rowers During Altitude Training: A Sex-Stratified Three-Arm Randomized Controlled Trial
This randomized controlled trial aims to investigate the effects of hot spring bath therapy on cognitive function recovery, cerebral hemodynamics, and athletic performance in athletes undergoing altitude training.
- Conditions
- Altitude Training Adaptation, Cognitive Function, Cerebral Hemodynamics, Exercise Performance
- Trial name
- NCT07608913
- Testing
- Control Group：Natural Recovery, Hot water immersion group, hot spring immersion group
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Behcet Syndrome
Neuro-ultrasound Assessment in Behcet's Disease
Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease
- Trial name
- NCT04738864
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University