Clinical trials: Cerebral Cortex Dysfunction
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Parkinson's Disease, Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops
Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease
Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Parkinson's Disease (PD) and its amplitude…
- Trial name
- NCT01284686
- Testing
- subthalamo-cortical loops stimulation in a one-sided and bipolar way
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Attention Deficit Disorder With Hyperactivity, Mental Disorders Diagnosed in Childhood
Brain Changes in Children and Adolescents With Behavioral Problems
Purpose: This study will examine brain activity in children age 10-18 with disruptive behavior problems, including conduct disorder (CD), oppositional defiant disorder (ODD), and attention deficit hyperactivity disorder (ADHD)…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Mental Disorders Diagnosed in Childhood, Conduct Disorder
- Trial name
- NCT00104039
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.
- Trial name
- NCT03723733
- Testing
- screen high and low triat subjects
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Tourette Syndrome
Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)
Tourette's syndrome (TS) is a debilitating and severe syndrome whose pathophysiology remains unclear. In order to precise the cortical regions involved in the generation of tics, investigators will realize an electroencephalogram…
- Trial name
- TIC-EEG (NCT03604510)
- Testing
- Electroencephalographic recordings
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Bordeaux
Dyslexia, Executive Dysfunction
The Effects of Play and Competition-Based Cognitive Therapy
Purpose: The aim of this study was to investigate the effects of play and competition-based cognitive therapy (PCB-CT) on executive function and occupational routines in children with dyslexia.
- Trial name
- NCT03906097
- Testing
- Play and Competition-Based Cognitive Therapy
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Tuberous Sclerosis Complex, Aspirin
Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
There had been much evidence in aspirin controlling tumorous conditions conducted by basic researches, especially through mammilian target of rapamycin (mTOR) pathway.
- Conditions
- Tuberous Sclerosis Complex, Aspirin, Epilepsy, Cognitive Decline
- Trial name
- NCT03356769
- Testing
- Aspirin, AED
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
Brief Overview: Children and adolescents diagnosed with cancer will experience problems with learning, memory and attention during and after completing their cancer therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation, Executive Dysfunction
- Trial name
- NCT04105530
- Testing
- Anodal tDCS treatment, Cathodal tDCS treatment, NIH Toolbox List Sorting Working Memory Test
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- St. Jude Children's Research Hospital