Clinical trials: Cerebral Cortex Dysfunction
Alzheimer Disease, Early Onset, Alzheimer Disease
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
This study attempts to identify two types of AD by using clinical and cognitive tasks and brain imaging. The subtypes of AD are separated into a "typical" group (memory loss) and a "variant" group (language, visuospatial, and…
- Conditions
- Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Disease, Late Onset, Dementia, Alzheimer Type
- Trial name
- EOAD-Subtype (NCT03153371)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cerebral Cortex Dysfunction
Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
This study will test whether primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) affect parts of the brain responsible for thinking, planning, memory and emotion.
- Trial name
- NCT00334516
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Dementia, Mild Cognitive Impairment
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
Widespread recognition of the current and projected impact of the dementia epidemic has spurred research into novel drug discovery efforts.
- Trial name
- SMArT-HS (NCT04120766)
- Testing
- Nicorandil
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gregory Jicha, MD, PhD
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Mild Cognitive Impairment, Dual Task
The Activation and Walking Speed of the Prefrontal Cortex of the Elderly Mild Cognitive Impairment During Dual Task.
The goal of this observational study is to compare to investigate the effect of dual task performance on straight and curved walking in elderly people with mild cognitive impairment.
- Trial name
- NCT05885867
- Testing
- Seniors with mild cognitive impairment over 65 years of age
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Sahmyook University
Mild Cognitive Impairment
Effects of tDCS on Cognition in MCI: A RCT
MCI is considered an intermediate stage between normal cognitive aging and dementia. As such, improving cognitive functions of people with MCI may delay dementia onset.
- Trial name
- NCT05584748
- Testing
- transcranial direct current stimulation
- Volunteers
- 48 people
- Sponsor
- Tung Wah College
Alzheimer Disease
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease.
- Trial name
- ADVISe (NCT04576793)
- Testing
- 11C-ER176, 18F-MK6240, 18F-Florbetaben
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Multiple Sclerosis
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
This study will test the ability of magnetic resonance imaging (MRI) to detect damage in different parts of the brain in patients with multiple sclerosis and to see if cognitive problems in patients can be correlated with the…
- Trial name
- NCT00393588
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Diabetic Neuropathy, Painful, Diabetes Mellitus, Type 1
Noninvasive Cortical Neurostimulation For Diabetic Neuropathic Pain
To investigate whether transcranial direct current stimulation can alleviate pain and sensory related disturbances in individuals with type 1 diabetes and peripheral neuropathy through neuromodulation of the CNS as compared to…
- Trial name
- NCT06152887
- Testing
- Sooma Oy (tDCS), Helsinki, Finland
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Jens Brøndum Frøkjær
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol in combination with cognitive training can improve cognitive abilities in older adults with Subjective…
- Trial name
- NACC-EC (NCT07212504)
- Testing
- Active Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Rotman Research Institute at Baycrest
Bipolar Disorder (BD), Cognitive Impairment
TMS for Improving Cognitive Function in Bipolar Disorder
Bipolar disorder is a highly disabling psychiatric illness, and cognitive impairment is common in patients with bipolar depression as well as during remission, contributing substantially to functional disability and poorer…
- Trial name
- NCT07414147
- Testing
- Active Intermittent Theta Burst Stimulation, Online Cognitive Training
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depressive Disorder, Major, Cognitive Impairment
Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder
Major depressive disorder (MDD) often involves cognitive deficits, particularly in cognitive flexibility, which is inadequately addressed by standard antidepressants.
- Trial name
- NCT07161492
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Second Xiangya Hospital of Central South University
Unipolar Depression, Bipolar Disorder
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat.
- Trial name
- NCT06363981
- Testing
- Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Stroke, Cognitive Deficit
Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits
The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.
- Conditions
- Stroke, Cognitive Deficit, Cognitive Impairment, Short-Term Memory Impairment
- Trial name
- TDCS-PSMWD (NCT03034109)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stony Brook University
Chronic Pain, Low Back Pain
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
The overarching goal of this study phase, Phase I component is to configure Computerized Chemosensory-Based Orbitofrontal Networks Training (CBOT) into Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment…
- Trial name
- CBOT-Pain (NCT06218407)
- Testing
- Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Evon Medics LLC
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas