Clinical trials: Chronic Respiratory Failure
Nutrition
Individualized Metabolic Assessment and Nutritional Optimization in Children With Chronic Respiratory Insufficiency
The investigators aim to examine the feasibility of individualized diet intervention in children dependent on long-term mechanical ventilator support at home.
- Trial name
- NutriCAPE (NCT02354495)
- Testing
- Changes in energy and protein intake
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Dyspnea, Heart Failure
Dyspnea and Biomarkers in a Prehospital Setting
In patients presenting with acute dyspnea in a pre-hospital setting, the early and correct diagnosis may present a significant clinical challenge.
- Conditions
- Dyspnea, Heart Failure, Asthma, COPD
- Trial name
- NCT00878475
- Where
- Slovenia
- Volunteers
- 546 people
- Sponsor
- Community Healthcare Center dr. Adolf Drolc Maribor (HCM)
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tracheobronchomalacia
Pressure Dependent Tracheal Obstruction in Copd Patients
Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study.
- Trial name
- PDTO (NCT01679808)
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- LHL Helse
Pulmonary Hypertension
Effect of Nasal Highflow on Right Heart Function
In this study effect of NHF on pulmonary thermodynamic parameters will studied.
- Trial name
- HÄMOFLOW (NCT02885116)
- Testing
- Nasal high flow (NHF) supplementation, oxygen supplementation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Leipzig
Heart Failure, Chronic Obstructive Pulmonary Disease
Person-centred Care at Distance
The goal of the research project PROTECT is to translate the Person-Centred Care (PCC) principles into an eHealth (the use of information and communication technologies for health) context.
- Trial name
- PROTECT (NCT03183817)
- Testing
- Person-centred care at distance
- Where
- Sweden
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF
This study was conducted to evaluate the safety and pharmacokinetics of an echocardiographic contrast agent, AI-700, in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and/or congestive heart failure…
- Trial name
- NCT00156780
- Testing
- AI-700
- Where
- United States
- Sponsor
- Acusphere
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Blood Stem Cell Transplant Failure, Graft Versus Host Disease
Pilot Study: Patients With Chronic Active Graft Versus Host Disease That Have Failed or Not Tolerated Standard Therapy.
By doing this study, researchers hope to understand the many changes that occur in the blood of people who have chronic GvHD. This may also help the researcher understand how ECP works and help guide therapy for patients who have…
- Trial name
- NCT01174277
- Testing
- Collection of blood sample
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Dyspnea, Chronic Renal Failure
POCUS VS CT in Diagnosis of Acute Dyspnea in Chronic Hemodialysis Patients
Estimate the predictive value of POCUS in diagnosis of different causes of acute dyspnea in hemodialysis patients and compare between POCUS and CT in differentiation the causes of acute dyspnea in those population.
- Trial name
- NCT05729035
- Testing
- POCUS
- Volunteers
- 100 people
- Sponsor
- Randa Ahmed Sarhan
Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis
European Home Mechanical Ventilation Registry
The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Muscular Dystrophies
- Trial name
- EHMVR (NCT02315339)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- ResMed
Chronic Coronary Syndrome, Heart Failure
COVID-19 Related Lockdown Effects On Chronic Diseases
The containment associated with the VIDOC-19 pandemic creates an unprecedented societal situation of physical and social isolation.
- Conditions
- Chronic Coronary Syndrome, Heart Failure, AMD and Macular Edema, Chronic Respiratory Failure
- Trial name
- CLEO-CD (NCT04390126)
- Testing
- life questionnaires, questionnaire
- Where
- France
- Volunteers
- 1,343 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
High-Flow Nasal Cannula, COPD
Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypercapnic COPD
To test if high-flow conditioned oxygen therapy is noninferior to NIV for preventing postextubation respiratory failure and reintubation in patients with hypercapnic COPD, investigators plan to conduct the participants level, 1:1…
- Trial name
- COPD (NCT03928535)
- Testing
- High-FlowNasal Cannula, Noninvasive Ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Allergic Rhinoconjunctivitis, Chronic Urticaria
Pharmacokinetic Study of Bilastine in Children From 2 to < 12 Years of Age With Either Allergic Rhinoconjunctivitis (AR) or Chronic Urticaria (CU)
The conduct of this clinical trial is aimed at determining the most suitable dose regimen for children in different age groups, and secondarily to assess the safety and tolerability of bilastine in this paediatric population…
- Trial name
- NCT01081574
- Testing
- Bilastine
- Where
- 7 sites in Australia, Germany and 1 more
- Volunteers
- 36 people
- Sponsor
- Faes Farma, S.A.
Dyspnea and Respiratory Insufficiency in Children
Multidimensional Characterization of Dyspnea in Children
There is no specific tool existing to describe dyspnea in children in a multidimensional way. It has been shown in adult studies that multidimensional dyspnea evaluation scales are well correlated to quality of life and…
- Trial name
- DYSPED (NCT05500833)
- Testing
- Multidimentional observation scale (MDP)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Asthma, COPD
Exhaled Breath Metabolomic Biomarkers in the Acutely Breathless Patient
An acute study carried out across three acute admissions units within Leicestershire. The study is aimed at discovery and validation of volatile organic compounds (VOCs) in exhaled breath.
- Conditions
- Asthma, COPD, Heart Failure, Community-acquired Pneumonia
- Trial name
- EMBER (NCT03672994)
- Where
- United Kingdom
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
COPD, Asthma (Diagnosis)
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases
This is a prospective, multicenter, observational cohort study enrolling approximately 4,000 subjects across about 50 centers, including patients with COPD (confirmed and suspected), asthma (confirmed and suspected)…
- Conditions
- COPD, Asthma (Diagnosis), Chronic Respiratory Diseases, Bronchiectasis
- Trial name
- NCT07631507
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan