Clinical trials: Cognitive Flexibility
Parkinson's Disease With Dementia
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
The project will investigate the effect of pharmacological and electric modulation of N-methyl-D-aspartate (NMDA) pathway on the cognitive flexibility and volitional movement preparation in patients with Parkinson's disease (PD).
- Trial name
- NCT01785628
- Testing
- Sarcosine Capsule
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Healthy Preschoolers
Fundamental Movement Skills Training Improves Executive Functions in Preschoolers
This randomized controlled trial investigated the effects of a 12-week structured fundamental movement skills (FMS) training program on executive functions in 34 healthy preschoolers aged 5-6 years.
- Trial name
- FMS-EF-RCT (NCT07725354)
- Testing
- Fundamental Movement Skills Training, Regular Physical Activity
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Xi'an Physical Education University
Anorexia Nervosa
Cognitive Remediation Therapy for Adolescents With Anorexia Nervosa
The purpose of the current study is to investigate the role of Cognitive Remediation Therapy (CRT) as a pre-treatment intervention for adolescents who are hospitalized for Anorexia Nervosa (AN).
- Trial name
- NCT02883413
- Testing
- CRT + Teach the Parent, CRT + Contact Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Child Development, Executive Functions (EF)
Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development
Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers.
- Conditions
- Child Development, Executive Functions (EF), Emotion Regulation
- Trial name
- STTT (NCT07666802)
- Testing
- Emotion-Focused Shared Picturebook Reading, Standard Dialogic Picturebook Reading
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Anorexia Nervosa, Atypical Anorexia Nervosa
Ketamine Effects on Learning In Eating Disorders
This is a single site, single dose clinical trial of intravenous (IV) ketamine for medically hospitalized adolescents and young adults with anorexia nervosa or atypical anorexia nervosa.
- Trial name
- KETTLE (NCT06736769)
- Testing
- Ketamine infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amanda Downey, MD
Military Personnel With High Pressure
Mindfulness-based Writing Expression Training Among Military Personnel
The goal of this clinical trial is to learn if mindfulness-based writing expression training works to improve stress and cognitive flexibility among military personnel.
- Trial name
- NCT07426341
- Testing
- mindfulness-based writing expression intervention, Regular Mental Health Education Group
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xiaofan Yan
Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy
Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients
The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD).
- Conditions
- Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy, Virtual Reality Cognitive Training, Cognitive Behavior Therapy
- Trial name
- OCD-VRET1 (NCT07245134)
- Testing
- Exposure Therapy (Virtual Reality), Cognitive flexibility training, Standard CBT program without VR interventions
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Cognitive Flexibility Among Female Teenagers
Correlation of Anti-gravity Muscle Strength With Glycemic Control, Duration of Disease, and Neuropathy Severity in Type 2 Diabetes Mellitus.
The study suggests that the high intensity exercise training program is beneficial for the female teenagers to enhance their cognitive abilities along with the physical strengthening.
- Trial name
- T2DM-AMS (NCT05873478)
- Testing
- High Intensity Interval Training
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Executive Function
Comparison Between Plyometrics and Calisthenics on Executive Function in School Going Children
The goal of this clinical trial is to compare the effects of calisthenics and plyometric exercises on executive functions in school-going children.
- Trial name
- NCT06770192
- Testing
- Calisthenics, Plyometric, Control
- Where
- Pakistan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Pain, Nociplastic Pain
Internet-Delivered Psychological Treatments for Chronic Pain in Adolescents: ACT and Pain Education.
One in four children in Sweden experiences chronic pain. For many, the pain is temporary, but for about 5% it significantly affects daily life, leading to sleep problems, school absence, and reduced physical activity.
- Conditions
- Chronic Pain, Nociplastic Pain, Pain Management, Acceptance and Commitment Therapy
- Trial name
- NCT06981312
- Testing
- Acceptance and Commitment Therapy, Pain Science Education
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Spastic Diplegic Cerebral Palsy
Effects of Transcranial Direct Current Stimulation Combined With Virtual Reality on Balance and Executive Functions in Children With Spastic Diplegic Cerebral Palsy
Children with spastic diplegic cerebral palsy commonly experience difficulties with balance and may also have challenges involving attention, working memory, cognitive flexibility, and inhibitory control.
- Trial name
- NCT07829770
- Testing
- Active Transcranial Direct Current Stimulation, Virtual Reality Rehabilitation, Conventional Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
ARFID, Anorexia Nervosa
Cognitive Evaluation of Patients With Eating Disorders
The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public…
- Conditions
- ARFID, Anorexia Nervosa, Bulimia Nervosa, Cognitive Flexibility
- Trial name
- DNA_ARFID (NCT07478510)
- Testing
- Go/No-go, IAT, WCST
- Where
- 3 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Eating Disorders, Hypoestrogenemia
The Role of Estrogen in the Neurobiology of Eating Disorders
This is a randomized, double blind, placebo-controlled study of the effects of transdermal estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder pathology in hypoestrogenemic female adolescents…
- Trial name
- NCT03740204
- Testing
- 17-β estradiol transdermal patches with cyclic progesterone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Anxiety Disorders, Depressive Disorder
Study on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents
This randomized controlled trial aims to evaluate the efficacy of a universal intervention based on Natural Psychotherapy in reducing anxiety and depressive symptoms among primary and middle school students.
- Conditions
- Anxiety Disorders, Depressive Disorder, Mental Health
- Trial name
- NP-A-MHP (NCT07639476)
- Testing
- Multi-modal Nature-based Meditation, Intervention diary
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Tic Disorders
Efficacy of Biofeedback in the Treatment of Tic Disorder
To investigate the efficacy of EEG biofeedback and drug therapy in the treatment of tic disorders
- Trial name
- NCT05361993
- Testing
- Drug Aripiprazole, biofeedback
- Where
- China
- Sponsor
- Children's Hospital of Fudan University