Clinical trials: Continuous Insulin Infusion System
Type 1 Diabetes
Expanding Coverage of Continuous Subcutaneous Insulin Infusion in Pediatric Patients With Diabetes
The purpose of the study is to present evidence based literature and clinical data to the medical directors at Missouri Medicaid to help modify the existing policy regarding insulin pump therapy in pediatric patients with…
- Trial name
- NCT00829062
- Testing
- Continuous glucose glucose sensor- physician ordered
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
Management of Glycemia Following a Pizza Meal
Glycemia following pizza consumption is typically managed with a dual wave insulin bolus. This study evaluated the effect of a simple bolus on glycemia following consumption of traditionally prepared pizzas with long (22 hours)…
- Trial name
- NCT03748251
- Testing
- the patients ate a pizza that fermented for 8 hours, the patients ate a pizza that fermented for 24 hours
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type1 Diabetes
Effect of Dual-wave Insulin Bolus on Postprandial Glycaemia
A study was conducted in adolescents with type 1 diabetes (T1D) examining the effect of different bolus types on 6-h postprandial glucose levels after the consumption of 3 standard meals with varying composition.
- Trial name
- NCT03179280
- Testing
- insulin
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Diabetes Mellitus Type 1
Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections to Reach HbA1c Targets in Children and Adolescents With Type 1 Diabetes
This study is to compare metabolic control, treatment satisfaction, and quality of life during continuous subcutaneous insulin infusion (CSII ) therapy with a new insulin pump system with multiple daily injections (MDI) therapy.
- Trial name
- Insight Kids (NCT02403375)
- Testing
- Accu-Chek Insight Pump System
- Where
- 9 sites in Austria, Germany and 1 more
- Volunteers
- 43 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Diabetes Mellitus, Type 1
Automated Closed-loop in Children and Adolescents With Type 1 Diabetes
People with type 1 diabetes need regular insulin injections or continuous delivery of insulin using a pump. Keeping blood sugars in the normal range is known to reduce long term complications.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam09 (NCT02129868)
- Testing
- Closed-loop (Android Closed-Loop platform)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Cambridge
Quality of Life, Burden, Dependency
Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life
The use by diabetes patients of real-time Continuous Glucose Monitoring (CGM) system is becoming widespread and has changed diabetic practice. Automated closed-loop (CL) insulin therapy has come of age.
- Trial name
- IMPLIQUE (NCT04939766)
- Testing
- Activation of a closed loop device in an insulin pump device with GCM
- Volunteers
- 250 people
- Sponsor
- VitalAire
Diabetes Mellitus, Diabetes Mellitus, Type 1
Closing the Loop in Children and Adolescents With Type 1 Diabetes in the Home Setting
Type 1 diabetes (T1D) is one of the most common chronic childhood diseases requiring lifelong insulin therapy. Children and adolescents with T1D need regular insulin injections or the continuous insulin delivery using an insulin…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam08 (NCT01778348)
- Testing
- Overnight closed-loop, Real-time CGM alone
- Where
- 3 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Cambridge
Type 1 Diabetes Mellitus
Shared Medical Decision Making in Pediatric Diabetes
This work is testing a shared medical decision making intervention for adolescents with type 1 diabetes and their parents who are candidates for adding either an insulin pump or continuous glucose monitor to their treatment plan.
- Trial name
- NCT02496156
- Testing
- Usual Clinical Practice, Shared Medical Decision Making
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
Clinical Efficacy of Insulin Pumps in Type 1 Diabetes Mellitus Patients in Spain
Observational cross-sectional multicenter study about clinical efficacy of insulin pumps in type 1 diabetes mellitus patients.
- Trial name
- NCT04761094
- Testing
- Insulin pump
- Where
- 25 sites in Spain
- Volunteers
- 2,977 people
- Sponsor
- Castilla-La Mancha Health Service
Type 1 Diabetes Mellitus
Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes
The Pizza-Salami-Study aims to investigate the efficacy of carbohydrate plus fat/protein (CFP) counting compared with carbohydrate (CARB) counting using normal and dual-wave bolus in sensor-augmented pump therapy in children and…
- Trial name
- NCT01400659
- Testing
- CFP counting, CARB counting
- Volunteers
- 42 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Type 1
Assessment of an Automatic Closed-loop Insulin Delivery System
The overall aim of this research proposal is to determine the safety, feasibility and efficacy of an automatic closed-loop insulin delivery system.
- Trial name
- NCT02366767
- Testing
- Automatic closed-loop insulin delivery, Control
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Type 1 Diabetes
Obtain a Good Blood Glucose Control With the Paradigm Real Time System
In this study, subjects with insufficient metabolic control despite optimized basal-bolus injection regimens were randomily assigned to either the Mini- Med Paradigm REAL-Time insulin pump (PRT), an insulin pump that can receive…
- Trial name
- RTD (NCT00441129)
- Testing
- Minimed paradigm Real Time Sytem, Minimed Paradigm 512/712 Insulin pump
- Where
- 8 sites in France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type I
Evaluation of Pharmacokinetics and Pharmacodynamic Properties of Rapid-Acting Insulin Analogs
The aim of this study is to evaluate the variations in pharmacokinetic and pharmacodynamic properties of rapid-acting insulin analogs when given as a bolus by subcutaneous insulin infusion pump as typically encountered in the…
- Trial name
- PK/PD (NCT00652288)
- Testing
- Insulin analogs (Lispro and Aspart), Insulin analogs (Aspart and Detemir), Insulin analogs (Lispro and Glargine)
- Volunteers
- 36 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
Evaluation of Novel Trend Arrow Adjustment Tool for Diabetes Patients Using Continuous Glucose Monitoring to Guide Insulin Bolus Adjustment (TAAT Study)
Continuous glucose monitoring (CGM) provides up to 288 blood glucose levels per day, updated every 5 minutes and displayed in real-time on the insulin pump, which can be used to enhance delivery of insulin through pump therapy.
- Trial name
- TAAT (NCT02064647)
- Testing
- Trend Arrow Adjustment Tool, 10/20% bolus adjustment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Eastern Ontario
Type 1 Diabetes
Evaluation of Glycemic Changes During Exercise in Children With Type 1 Diabetes
The objectives of the study are: 1) to evaluate the effects of moderate exercise on SG evolution without insulin dose modification in patients with T1D under continuous subcutaneous insulin infusion (CSII) and multiple daily…
- Trial name
- TREAD-DIAB (NCT02824510)
- Testing
- Algorithmic changes in insulin therapy., Treadmill exercises, Insulin aspart, glargine and detemir
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diabetes Mellitus, Type 1, Pediatric ALL
Intensive Versus Standard One Year Monitoring on Glycaemic Control After Initiating CSII in Children With DT1. DEEP Study
More than half of type 1 diabetes (DT1) children are under CSII (Continuous Subcutaneous Insulin Infusion). Several studies showed that despite a patients' follow-up mostly by hospital-based paediatricians, there are still some…
- Trial name
- DEEP (NCT04100070)
- Testing
- Monitoring of the patients
- Where
- France
- Volunteers
- 320 people
- Sponsor
- ISIS Diabete Service
Diabetes Mellitus, Type 1 Diabetes
Closed Loop From Onset in Type 1 Diabetes
The purpose of the study is to use a novel treatment approach, the artificial pancreas, after diagnosis of type 1 diabetes (T1D) to improve glucose control with the anticipated improvements of residual C-peptide secretion.
- Trial name
- CLOuD (NCT02871089)
- Testing
- Closed-loop system (Florence M or CamAPS FX), Multiple Daily Injections
- Where
- 7 sites in United Kingdom
- Volunteers
- 96 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Insulin-Dependent
Insulin Pump Therapy in Adolescents With Newly Diagnosed Type 1 Diabetes (T1D)
Within 4 weeks after diagnosis of type 1 diabetes, 10 subjects (pubertal males, 12-17 years old) will be randomized to either receive multiple daily injection (MDI) using Lantus insulin, or continuous subcutaneous insulin…
- Trial name
- NCT00357890
- Testing
- Insulin pump therapy, Multiple daily injections using insulin glargine + rapid acting analog
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Diabetes Mellitus, Type 1
Home Testing of Day and Night Closed Loop With Pump Suspend Feature
The main study objective is to determine whether day and night automated closed loop glucose control combined with pump suspend feature will improve glucose control and reduce the burden of hypoglycaemia compared to sensor…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam11 (NCT02523131)
- Testing
- FlorenceM, Medtronic insulin pump 640G
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 84 people
- Sponsor
- University of Cambridge
Diabetes type1
Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps.
This is a randomized, cross-over study. The aim of this study is to compare the post-prandial glycaemic variability after pure protein meal following with an administration of square-wave bolus of meal-insulin or without any…
- Trial name
- NCT02685449
- Testing
- Insulin glulisine, Insulin aspart, Insulin lispro
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw