Clinical trials: Cornea
Keratoconus
Retrospective Digital Computer Analysis of Keratoconus Evolution - REDCAKE
The purpose of this study is to create a database of keratoconic eyes with two or more corneal topographies/tomographies, at least 5 months apart
- Trial name
- REDCAKE (NCT03235856)
- Where
- Belgium
- Volunteers
- 972 people
- Sponsor
- University Hospital, Antwerp
Corneal Transplantation
The German Keratoplasty Registry of the German Ophthalmological Society (DOG)
Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany.
- Trial name
- NCT03381794
- Testing
- Corneal transplantation
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- Universität des Saarlandes
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Keratoconus, Corneal Opacity
OCT in Diagnosis of Irregular Corneas
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.
- Conditions
- Keratoconus, Corneal Opacity, Corneal Dystrophy
- Trial name
- NCT03504800
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Persistent Corneal Epithelial Defect
Comparison of Topical Insulin and Amniotic Membrane Transplant for Persistent Corneal Epithelial Defects
After an initial period of standard treatment, they received further care aimed at helping the surface of the eye heal. Clear instructions were given on how to use and store the treatment properly.
- Trial name
- NCT07561398
- Testing
- Topical insulin eye drops, Amniotic Membrane Graft
- Where
- Pakistan
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Al-Shifa Trust Eye Hospital
Keratoconus, Collagen Diseases
Correlation Between Q-value Changes and Progression of Pediatric Keratoconus.
Keratoconus is a progressive corneal disease characterized by asymmetric corneal thinning and structural changes in corneal collagen which leads to decrease in visual acuity due to myopic shift, irregular astigmatism or corneal…
- Conditions
- Keratoconus, Collagen Diseases, Corneal Disease
- Trial name
- NCT05114928
- Testing
- Transepithelial Corneal Collagen Cross-linking, Scheimpflug camera
- Where
- Egypt
- Volunteers
- 9 people
- Sponsor
- Benha University
Eye Disease
Digital Photography to Evaluate Dry Eye
Surface eye problems (problems of the cornea and conjunctiva), such as dry eye, are often evaluated using ocular surface staining - the application of a colored dye to the surface of the eye.
- Trial name
- NCT00073099
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Eye Institute (NEI)
Vaccinia
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination
This study will evaluate patients with eye complications related to vaccination against smallpox to learn more about these conditions. Vaccinia vaccination has been used for more than 100 years for preventing smallpox.
- Trial name
- NCT00081835
- Testing
- NP-016 Vaccine Immune Globulin (IV-VIG)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)
Trachoma, Yaws
Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )
This is a cluster randomised trial evaluating the safety of co-administering Azithromycin alongside the new IDA (Ivermectin, Diethylcarbamazine, Albendazole) combination treatment for LF.
- Conditions
- Trachoma, Yaws, Lymphatic Filariases, Scabies
- Trial name
- NCT03676140
- Testing
- Albendazole on Day 1, Ivermectin on Day 1, Diethylcarbamazine on day 1
- Where
- Papua New Guinea
- Volunteers
- 20,000 people
- Sponsor
- Lihir Medical Centre
Trachoma
Azithromycin in Control of Trachoma II
Trachoma is the world's leading cause of preventable blindness. This disease, caused by Chlamydia trachomatis, is endemic in many parts of the developing world.
- Trial name
- NCT00286026
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Keratoconjunctivitis, Conjunctivitis
Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis
To investigate the long-term efficacy and safety of FK506 ophthalmic suspension in patients with vernal keratoconjunctivitis
- Trial name
- NCT00567918
- Testing
- FK506
- Where
- 8 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Astellas Pharma Inc