Clinical trials: Corneal Crosslinking
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Keratoconus
McNeel Eye Center Corneal Crosslinking Study
This study will investigate the effectiveness in treating keratoconus, pellucid marginal degeneration and post LASIK iatrogenic ectasia utilizing fluence rates and treatment times of Corneal Cross Linking other than the original…
- Trial name
- NCT02921009
- Testing
- Crosslinking using UV light of two different fluence rates
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McNeel Eye Center
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Keratoconus, Ectasia
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01189864
- Testing
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 16 sites in United States
- Volunteers
- 3,493 people
- Sponsor
- Cxlusa
Keratoconus
Conventional Collagen Crosslinking in Young Keratoconus
Keratoconus is a chronic progressive non - inflammatory disorder characterised by progressive steepening and thinning of cornea and high myopic astigmatism, accounting for poor visual acuity in such individuals.
- Trial name
- PED-CXL (NCT02008175)
- Testing
- Conventional CXL
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Vasan Eye Care Hospital
Infective Keratitis
The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis
This was a prospective, single centre, randomised controlled study to evaluate the clinical effectiveness of corneal collagen crosslinking as an adjuvant to antimicrobial therapy.
- Trial name
- NCT06967376
- Testing
- Corneal Collagen Cross-Linking Solutions, Topical Antimicrobial/Antifungal Medications
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Keratoconus, Keratoconus, Unstable
Epi-On Corneal Crosslinking for Keratoconus
Epithelium-On Corneal Crosslinking for Keratoconus.
- Trial name
- NCT03245853
- Testing
- Riboflavin 5'-Phosphate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Comprehensive EyeCare of Central Ohio
Keratoconus, Cornea Disease
Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
The cornea plays a fundamental role in vision, being a complex tissue essential for ocular health. In ophthalmological practice, there are situations such as corneal crosslinking, where damage to the corneal epithelium occurs.
- Conditions
- Keratoconus, Cornea Disease, Eye Diseases, Wound Healing
- Trial name
- NCT06601101
- Testing
- NPH insulin 50 IU/mL eye drops
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Campinas, Brazil
Unstable Corneas
Corneal Cross-Linking Comparing Variables
The purpose of this study is to evaluate the Safety and Efficacy of Corneal Cross Linking in a Continuous Beam versus Pulsed Treatments across epithelium on and epithelium off surfaces.
- Trial name
- NCT02095730
- Testing
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Crowd Health Research, LTD
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa