Clinical trials: Cost-effectiveness
Osteoarthritis
Cost Efficacy of a Clinical Pathway to Patients Undergoing Hip and Knee Replacement Surgery
In this randomised study a proactive care and rehabilitation intervention is compared to the current care and rehabilitation in patients undergoing primary hip and knee replacement surgery.
- Trial name
- NCT00175201
- Testing
- Proactive care and rehabilitation
- Where
- Denmark
- Volunteers
- 247 people
- Sponsor
- University of Aarhus
PrEP, HIV Prevention
The Community PrEP Study to Assess the Acceptance of PrEP Delivered Through CBCT Platforms
The investigators aim to 1) speed up access to and delivery of PrEP to young women, and 2) compare interventions to support and maximize the prevention-effective use of PrEP.
- Conditions
- PrEP, HIV Prevention, Adolescence, Cost-effectiveness
- Trial name
- NCT03977181
- Testing
- Group-based Community Health Club, Individual-based Adherence Support
- Where
- South Africa
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Psychological Distress
Investigating the (Cost-)Effectiveness of an Online Social Therapy Platform (ENYOY) for Young People Aged 16-25 on Mental Healthcare Waiting Lists
This study, run by Amsterdam UMC in the Netherlands, looks at whether an online mental health platform called ENYOY can help reduce psychological distress in young people aged 16 to 25 who are waiting for mental health care.
- Trial name
- ENYOY:nextstep (NCT07594756)
- Testing
- ENYOY, Care As Usual
- Where
- Netherlands
- Volunteers
- 225 people
- Sponsor
- Academisch Medisch Centrum - Amsterdam UMC Research BV
Substance Use Disorders, Recidivism
Preventing OUD in Justice-Involved Youth
The United States is experiencing an opioid epidemic. Sadly, opioid-related fatalities are on the rise, causing profound emotional, financial, and cultural impacts.
- Trial name
- POST (NCT04901312)
- Testing
- Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Seattle Children's Hospital
Parkinson Disease
Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease
The majority of people with Parkinson's disease incur Freezing of Gait (FoG), which is not addressed adequately by medication. Cueing is a proven strategy to overcome FoG.
- Trial name
- NCT06416345
- Testing
- Cue2Walk, Usual Care
- Where
- 2 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Amsterdam UMC, location VUmc
Severe Malaria, Severe Anaemia
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria…
- Trial name
- PDMC-SL (NCT06601712)
- Testing
- Adherence support strategy A, Adherence support strategy B, Control
- Where
- 2 sites in Benin
- Volunteers
- 648 people
- Sponsor
- Institut de Recherche Clinique du Benin
Dental Caries
Cost-efficacy of Atraumatic Restorations (ART) Using Different Encapsulated Glass Ionomer Cement
Given the clinical damage caused by errors commonly made during the dosage and handling of glass ionomer cement (GIC) of high viscosity powder-liquid type, the use of encapsulated ionomer has been recommended for final…
- Trial name
- NCT02730000
- Testing
- ART with Equia, ART with Riva Self Cure
- Where
- Brazil
- Volunteers
- 148 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease (COPD)
A Randomized Controlled Trial to Determine Outcome and Cost Effectiveness of Case Management of Chronic Obstructive Pulmonary Disease (COPD) Patients
This randomized controlled trial (RCT) will examine a nurse case management model for patients suffering from chronic obstructive pulmonary disease (COPD) in a Danish municipality, and is performed in order to evaluate the use of…
- Trial name
- NCT01512836
- Testing
- Case Management
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Kronikerenheden Nordjylland
Cyanide Poisoning
Hydroxycobalamin and Rural Emergency Medical Services Cyanide Exposure Patients: A Cost Analysis
The costs to a rural emergency medical services (EMS) system of a change from a traditional cyanide antidote kit to a kit containing hydroxocobalamin alone are currently unknown.
- Trial name
- NCT01656616
- Testing
- Cyanide antidote administration
- Where
- United States
- Sponsor
- MaineHealth
Fever, Malaria
Parasite-based Diagnosis for Malaria in Uganda: Feasibility and Cost-Effectiveness
The purpose of this study is to compare the cost-effectiveness of treating malaria based on three methods of diagnosis (rapid test, microscopy and presumptive diagnosis) among patients attending level three government health…
- Trial name
- NCT00565071
- Testing
- Field microscopy and Paracheck Pf®
- Where
- Uganda
- Volunteers
- 102,087 people
- Sponsor
- Makerere University
Severe Acute Malnutrition
Modified Dosage for Severe Acute Malnutrition
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-SAM (NCT06061484)
- Testing
- ready-to-use therapeutic food (RUTF), Amoxicillin
- Where
- 3 sites in Ethiopia
- Volunteers
- 2,400 people
- Sponsor
- Action Against Hunger USA
Depression
Implementing Telemedicine-Based Collaborative Care for MDD in Contract CBOCs
Small contract VA Community Based Outpatient Clinics present unique challenges to implementation of collaborative care because of their distinct organizational characteristics and lack of on-site psychiatrists.
- Trial name
- NCT00317018
- Testing
- Evidence-Based Quality Improvement
- Where
- 2 sites in United States
- Sponsor
- US Department of Veterans Affairs
Second Degree Burn
Evaluating the Cost-effectiveness, Efficacy, Safety and Tolerance of Mepilex® Ag Versus Silvadene®
The primary objective is to compare the incremental costs (direct and indirect) and benefits (healing outcomes, quality of life) of using foam silver dressing (Mepilex® Ag) to a Silver sulfadiazine 1% cream (Silvadene®) from the…
- Trial name
- NCT00742183
- Testing
- Mepilex, Silvadene
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Molnlycke Health Care AB
Childhood Obesity
Hyvinkää Childhood Obesity Study (HCOS), Randomized Controlled Clinical Trial for Effectiveness and Costs of a 1-year Lifestyle Intervention.
The aim of this study is to evaluate the effects of lifestyle intervention on the management of childhood overweight and to explore the factors that contribute to the outcome, as well as the costs for the health care system.
- Trial name
- HCOS (NCT06126679)
- Testing
- 1-year dietary and physical activity intervention of childhood obesity
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Helsinki University Central Hospital
Solution-focused Capability, Mental Well-being
Evaluation of the School-based SIM Program in Upper Secondary School Students
The Solution-Focused Intervention for Mental Health (SIM) is a universal, school-based programme designed to promote mental well-being among adolescents.
- Conditions
- Solution-focused Capability, Mental Well-being, Mental Problems, Perceived Stress
- Trial name
- SIMRCT1 (NCT07111676)
- Testing
- The Solution-focused Intervention for Mental health (SIM)
- Where
- Sweden
- Volunteers
- 727 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Sarcomas
An Adequate Cost Effective Follow Up Protocol For Bone and Soft Tissue Sarcomas
Bone and soft tissue sarcomas are rare tumors, accounting for approximately 1% of all adult malignancies. The majority of bone and soft tissue sarcomas occur in the extremities.
- Trial name
- TOSS (NCT05827458)
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Tata Memorial Hospital
Cholera
Cholera Vaccine Investment Strategy in Bangladesh
To evaluate the preventive impact, demand, acceptability, uptake, feasibility, and cost-effectiveness of a two-dose regimen of the OCV Shanchol in children living in urban slums in Bangladesh, Investigators will conduct a…
- Trial name
- CVIS (NCT02727855)
- Testing
- Shanchol
- Where
- Bangladesh
- Volunteers
- 75,170 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Endometrial Cancer
ENdometrial Cancer SURvivors' Follow-up carE (ENSURE): Less is More?
Background: It has often been hypothesized that the frequency of follow-up for patients with early-stage endometrial cancer could be decreased.
- Trial name
- ENSURE (NCT02413606)
- Testing
- Reduced follow-up schedule
- Where
- 47 sites in Netherlands
- Volunteers
- 319 people
- Sponsor
- Comprehensive Cancer Centre The Netherlands
Immunization Coverage, Vaccination
Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months
Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization…
- Conditions
- Immunization Coverage, Vaccination, Nutrition
- Trial name
- NCT06387511
- Testing
- Small-quantity lipid-based nutrition supplements (SQ-LNS) NutriVax, Sensitization on vaccination and on Infant and Young Child Feeding (IYCF) practices
- Where
- Nigeria
- Volunteers
- 3,814 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Cost-effectiveness of Exercise-based Rehabilitation Program
Effectiveness of Exercise Cardiac Rehabilitation
The objective of this multidisciplinary study is to employ health-economic evaluation in determining the health benefits achieved with exercise-based cardiac rehabilitation and the costs derived from it compared with conventional…
- Trial name
- EFEX-CARE (NCT01916525)
- Testing
- Exercise based cardiac rehabilitation
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- University of Oulu