Clinical trials: DNA Methylation
Aberrant DNA Methylation
Methyl-Donors and EpiGenetics in The Gambia
Accumulating evidence suggests that early-life nutrition can affect metabolism and thus increase the risk of disease in adulthood (e.g. type II diabetes and obesity).
- Trial name
- MDEG (NCT01811641)
- Testing
- season, dietary intake
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
Preterm Birth, Parent-Child Relations
Epigenetics and Protective Factors in the Preterm Infant
Preterm infants (PT) spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to unfavorable conditions with different effects on child development including long-term alterations in…
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- EPIC (NCT04804280)
- Testing
- DNA methylation of target genes, Functional Magnetic Resonance Imaging (fMRI) acquisition
- Where
- Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Bladder Cancer, Urocystitis
A Multicenter Clinical Trial of Urine DNA Testing for Bladder Cancer in China
The primary objective of this study is to assess the safety and effectiveness of Human Multigene Methylation Detection Kit (Fluorescent PCR Method) for help diagnose bladder cancer by comparing with clinical standard method…
- Conditions
- Bladder Cancer, Urocystitis, Urinary Bladder Stone, Urothelial Carcinoma
- Trial name
- NCT05337189
- Testing
- Urine DNA methylation analysis, medical imaging and/or cystoscopy and/or pathological examination
- Where
- China
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Type 1 Diabetes Mellitus
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)
Type 1 Diabetes Mellitus (T1DM) is a well-studied autoimmune disease resulting in insulin deficiency due to selective β-cell destruction.
- Trial name
- METHYLDIAB (NCT04139369)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Epigenomics, Developmental Disability
Early Parenting Intervention: Bio-behavioral Outcomes in Infants With Neurodevelopmental Disabilities
Infants with developmental disabilities present a high risk of behavioral and socio-emotional problems. Their parents are themselves at risk of developing emotional and affective disorders which can impact the quality of the…
- Conditions
- Epigenomics, Developmental Disability, Early Intervention, Parent-Child Relations
- Trial name
- EPI-BOND (NCT03853564)
- Testing
- Video-Feedback Intervention, Phone-Call Intervention
- Where
- 3 sites in Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Eugenio Medea
Maltreatment, Child
Differential DNA Methylation as a Function of a Parenting Intervention
The aim of this study is to experimentally assess whether an early parenting intervention for maltreating parents results in differential epigenetic marking of children's genome, particularly of DNA associated with immune system…
- Trial name
- NCT03374969
- Testing
- Attachment and Biobehavioral Catch-Up, Developmental Education for Families
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Stunting, Development, Child
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
The investigators will conduct a case-control study among under-two children in Lombok Timur, West Nusa Tenggara, Indonesia. The power required to detect changes in epigenetic markers may not be sufficient in the cohort study.
- Conditions
- Stunting, Development, Child, DNA Methylation, Epigenetics
- Trial name
- MINUTES (NCT05779904)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Urothelial Carcinoma
Arsenic Methylation Enzymes, Cigarette Metabolites, DNA Repair Enzymes, Inflammatory Factors and Urothelial Carcinoma
1. To investigate the relationship between arsenic methylation enzymes (AS3MT, PNP,GSTO1, and GSTO2) genetic polymorphism and UC risk. 2.
- Trial name
- NCT00854464
- Where
- Taiwan
- Volunteers
- 420 people
- Sponsor
- National Taiwan University Hospital
Liver Fibrosis
Multiomics Study of Fibrosis Factors After Liver Transplantation and Exploration of Fibrosis Methylation Biomarkers
This is a retrospective observational study in liver transplantation recipients with or without allograft liver fibrosis. Based on the GM-seq and Tcr-Seq data, a novel diagnostic model including DNA-methylation and TCR-Seq…
- Trial name
- NCT05926778
- Testing
- Liver allograft fibrosis
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Cardiovascular Risk Factor
Overcoming Obstacles in Epigenetic Analysis of Human Twins
Background Cardiovascular disease is the leading cause of death in the U.S., however scientists have failed to learn fully what are the causes of this disease.
- Trial name
- Epitwin (NCT04279704)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hepatocellular Carcinoma (HCC)
Hepatocellular Carcinoma 3 Gene Methylation Combination Detection Kit (PCR Fluorescent Probe Method) Multicenter Clinical Trial
This clinical trial aims to systematically evaluate the clinical performance and accuracy of the HepaAiQ test kit, a multi-gene methylation assay based on PCR with fluorescent probe detection.
- Trial name
- NCT06842563
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Singlera Genomics Inc.
Hashimoto Thyroiditis, Graves Disease
DNA Methylation and Autoimmune Thyroid Diseases
Hashimoto Thyroiditis (HT) and Graves Disease (GD) are known to be caused by abnormal immune response against self cells and tissues.
- Trial name
- THYRODNA (NCT02491567)
- Where
- Greece
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Gastric Carcinoma
DNA Methylation Biomarkers and Metastasis of Gastric Carcinoma
Gastric carcinoma (GC) is the second leading cause of cancer death throughout the world. In previous multi-center study, we have found that the prevalence of GDNF family receptor alpha 1(GFRA1), serum response factor (SRF), and…
- Trial name
- NCT02159339
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer Screening, Lynch Syndrome
DYNAMICS-LYNCH：DNA Methylation Analysis in Stool for Screening of Lynch Syndrome-Associated Colorectal Cancer
Colorectal cancer (CRC) has high incidence and mortality rates globally. Over 1 million new cases are diagnosed annually, and about 600,000 people die from the disease each year.
- Trial name
- NCT06772844
- Testing
- fecal DNA methylation testing
- Volunteers
- 400 people
- Sponsor
- Sun Yat-sen University
Lung Adenocarcinoma, Surgery
DNA Methylation Biomarkers to Predict Survival After Surgery for Lung Adenocarcinoma
This study is designed to assess DNA 5-methylcytosine (5mC) methylation modifications in lung adenocarcinoma (LUAD) samples and develop a prognosis-predictive model for LUAD based on cancer tissue DNA 5mC levels.
- Conditions
- Lung Adenocarcinoma, Surgery, Prognostic Cancer Model
- Trial name
- NCT06477211
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Nanjing University
Primary Brain Tumor
Serum DNA Analysis: Potential Application for Diagnosis and Prognosis in Brain Cancer.
Numerous studies document the ability of tumors to shed DNA into the blood stream. Circulating DNA can thus be recovered for analyses, representing a surrogate tumor material to test for potential applications in disease…
- Trial name
- NCT00265174
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Ovarian Cancer
The Epigenetic Regulatory Role of P-element Induced Wimpy Testis (Piwi) Interacting RNA-823 (piR-823) in Ovarian Cancer Progression
Ovarian cancer (OC) has one of the highest mortality rates for female malignant tumors, attributed to advanced cancer stages upon diagnosis as well as a high recurrence rate.
- Trial name
- NCT06320418
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Methylation, Body Composition
Diet and Nutrition Pilot Study for Chinese Adolescents and Their Mothers
Background: Researchers want to collect information on diet, physical activity, and sun exposure in children and young adults. The data can provide information on the effect these factors might have on the development of cancer…
- Conditions
- Methylation, Body Composition, Physical Activity, Puberty
- Trial name
- NCT01517139
- Where
- China
- Volunteers
- 278 people
- Sponsor
- National Cancer Institute (NCI)
Emergence Delirium, Postoperative Complications
Epigenetics in PostOperative Pediatric Emergence Delirium
Emergence delirium (ED) infers the occurrence of behavior and cognition changes during the early postoperative period. Main signs and symptoms of ED are the disturbances of consciousness and awareness of the environment, with…
- Conditions
- Emergence Delirium, Postoperative Complications, DNA Methylation
- Trial name
- EPOPED (NCT03787849)
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo