Clinical trials: Defects
Congenital Heart Disease, Health Behavior
Heart2Heart for Teens With CHD
The goal of this clinical trial is to learn if teens living with congenital heart disease like and will use Heart2Heart and if it affects how they think and feel about e-cigarettes.
- Trial name
- NCT07764510
- Testing
- Heart2Heart
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Kristen Fox
Congenital Heart Diseases, Aortic Valve Disorder
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of…
- Trial name
- NCT01619982
- Testing
- Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
Bronchopulmonary Dysplasia, Patent Ductus Arteriosus
MISA to NRDS：a Multicenter Study in China
BACKGROUND Treatment of neonatal respiratory distress syndrome with exogenous surfactant and mechanical ventilation made millions of preterm infants survived in neonatal intensive care unit (NICU).
- Conditions
- Bronchopulmonary Dysplasia, Patent Ductus Arteriosus, Intraventricular Hemorrhage, Necrotizing Enterocolitis
- Trial name
- NCT04077333
- Testing
- Minimal Invasive surfactant administration
- Where
- China
- Volunteers
- 237 people
- Sponsor
- Peking University Third Hospital
Molar Incisor Hypomineralization
Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization
The goal of the study is to evaluate the clinical performance of giomer sealant preceded by etching versus resin-based sealants applied on first permanent molars affected by molar incisor hypomineralization (MIH) The main…
- Trial name
- NCT06922552
- Testing
- Giomer pit and fissure sealant with etching applied on Permanent Molars Affected by MIH, Resin based sealant applied on Permanent Molars Affected by MIH
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Wolff-Parkinson-White Syndrome
Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation
Prospective cohort study including 150 patients with pre-excitation on ECG referred to our clinic for risk assessment. There will be equal numbers of symptomatic and asymptomatic patients included in the study.
- Trial name
- RASAP (NCT03301935)
- Testing
- Electrophysiology testing and exercise stress testing
- Where
- Sweden
- Volunteers
- 168 people
- Sponsor
- Karolinska University Hospital
Spina Bifida, Cerebral Palsy
Assessing Transition Practices for Children With Disabilities: Pathways to a Successful Adulthood
Transition to adult care is a purposeful and structured movement of youth with complex disabilities from child centered to adult oriented services. This complex and potentially challenging period requires careful planning.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Spastic Paraplegia
- Trial name
- NCT07706517
- Testing
- Chart review, Semi-structured interview
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Congenital Heart Defect
XFM: (X-ray Fused With MRI) Guided Cardiac Catheterization
This study will evaluate the use of x-ray fused with MR images as an imaging tool to help guide catheter tools during diagnostic and therapeutic cardiac catheterization procedures.
- Trial name
- NCT02737579
- Testing
- XFM guidance
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Joshua Kanter
Congenital Heart Disease
Effect of eHealth Encouragements to Intensive Exercise in Adolescents With Congenital Heart Disease
All over the world 0.8 % of all live children are born with a Congenital Heart Disease (CHD) due to genetic end environmental causes.
- Trial name
- PReVaiL (NCT01189981)
- Testing
- Lifestyle counseling, eHealth intervention
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mechanical Ventilation Complication, Congenital Heart Disease
Application of Neurally Adjusted Ventilatory Assist to Children After Congenital Cardiac Surgery
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Trial name
- NCT01662011
- Testing
- mode of neurally adjusted ventilatory assist, Mode of pressure support ventilation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
22q11.2 Deletion Syndrome
Effects of Methylphenidate on Brain and Cognition in 22q11 Deletion Syndrome
Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated with a high risk of psychiatric disorders, including schizophrenia spectrum disorders.
- Trial name
- NCT04647500
- Testing
- Concerta
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Geneva, Switzerland
Long QT Syndrome
Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care
The purpose of this study is to further develop and evaluate a diagnostic procedure suitable for use in an inexpensive diagnostic instrument suitable for screening for Long QT Syndrome (LQTS) in the primary care environment.
- Trial name
- NCT04441892
- Testing
- QTc Meter
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Molar Incisor Hypomineralisation, Children
This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.
The aim of this study is three-fold: 1. To evaluate the clinical performance of glass ionomer fissure sealants and resin fissure sealants when placed immediately after or one week following the application of silver fluoride on…
- Conditions
- Molar Incisor Hypomineralisation, Children, Dental Caries
- Trial name
- NCT06641011
- Testing
- Immediate restoration (resin- based) after blot-drying silver fluoride application, Immediate restoration (GI- based) after blot-drying silver fluoride application, Immediate restoration (Resin based) after rinsing silver fluoride application
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Ebstein Anomaly, Tricuspid Valve Dysplasia
Fetal Ebstein Anomaly and Tricuspid Valve Dysplasia Registry
Ebstein anomaly and tricuspid valve dysplasia (EA/TVD) are rare congenital tricuspid valve malformations that carry among the highest mortality of all congenital heart disease diagnosed in utero.
- Trial name
- FEAT Registry (NCT05225311)
- Testing
- Observation
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- The Hospital for Sick Children
Marfan Syndrome
Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Marfan Syndrome
Transforming Growth Factor Beta (TGF-β) is a protein that controls proliferation, cellular differentiation, and other functions in most cells.
- Trial name
- NCT01361087
- Testing
- Blood draw
- Where
- United States
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH)
Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization
The main questions this study aims to answer are: Does computer-controlled local anesthesia cause less pain and anxiety than conventional local anesthesia in children with molar-incisor hypomineralization (MIH)? Is there a…
- Conditions
- Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH), Computer-Controlled Local Anesthesia
- Trial name
- NCT07733011
- Testing
- Computer-Controlled Local Anesthesia, Conventional Local Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dexmedetomidine, Congenital Heart Disease
Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease
The main objectives of the study are to determine peak plasma drug concentration levels and corresponding time of dexmedetomidine following intranasal administration in children age ≥1 mo to ≤ 6 yr with congenital heart disease…
- Trial name
- NCT03417999
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Defects
Neurodevelopmental Rehabilitation for Toddlers With Complex Heart Defects
The purpose of this project is to investigate the feasibility of using a home-based, parent-delivered model for providing neurodevelopmental rehabilitation programmes to infants who have had surgery for a complex heart defect.
- Trial name
- NCT01239784
- Testing
- Home-based neurodevelopmental rehabilitation programme
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Congenital Disorders
Optimal Timing for Repair of Right-to-Left Shunt Lesions
The primary aim of this study is to determine the optimal timing for repair of right-to-left shunt lesions such as Tetralogy of Fallot defects. The secondary aim being define the criteria for failing medical therapy.
- Trial name
- NCT00268099
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Children's Healthcare of Atlanta
Enterocolitis, Necrotizing, Congenital Heart Disease
Utility of Bowel Ultrasound in Diagnosing Necrotizing Eneterocolitis in Congenital Heart Disease
To evaluate the feasibility of performing a randomized pilot control trial of two diagnostic screening strategies for necrotizing enterocolitis in patients with congenital heart disease.
- Trial name
- NCT03142685
- Testing
- Bowel Ultrasound
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
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