Clinical trials: Deformity of Face
Cleft Palate, Surgery
Analgesic Contribution of the Suprazygomatic Maxillary Nerve Block for Cleft Palate Surgery in Children
This is a monocentric prospective randomized simple-blind designed study evaluating the superiority of the suprazygomatic maxillary nerve block in analgesia after cleft palate surgery compared with a control group.
- Trial name
- Suprazyg (NCT04023825)
- Testing
- suprazygomatic maxillary nerve block
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Orbital Bone Fracture, Maxillary Cyst
Application of CAD-CAM Technology in Orbital Bone Reconstruction
Reconstruction of orbital defects resulting after trauma; tumor resection; maxillary cyst; craniofacial anomalies and sequestrated bone….
- Conditions
- Orbital Bone Fracture, Maxillary Cyst, Maxillary Neoplasms, Zygomatic Fractures
- Trial name
- CAD-CAM (NCT05438784)
- Testing
- orbital bone reconstruction with patient specific titanium implant, orbital bone reconstruction with preformed titanium plate preoperatively bended on stereolithographic model
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Hatem Adel Aboelhassan
Dento Facial Dysmorphism
Evaluation of Maxillary and Mandibulary Nerve Blocks on Morphine Consumption
Background and Objectives: Double-jaw surgery is one of the most painful oral surgery, requiring multimodal analgesia including controlled morphine pump and its secondary effects.
- Trial name
- NCT03299998
- Testing
- Maxillary and mandibular blocks, General anesthesia
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Hospices Civils de Lyon
22Q11.2 Deletion Syndrome
Open-Label Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents With 22q11.2 Deletion Syndrome (INSPIRE)
To evaluate the safety and tolerability of ZYN002 administered as a transdermal gel formulation, for up to 38 weeks, in participants ages 4 to <18 years, in the treatment of 22q.11.2 Deletion syndrome (22qDS).
- Trial name
- INSPIRE (NCT05149898)
- Testing
- ZYN002
- Where
- 3 sites in United States, Australia
- Volunteers
- 20 people
- Sponsor
- Harmony Biosciences Management, Inc.
Malignant Tumor, Benign Neoplasm
Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital
This retrospective observational study aims to evaluate the efficacy and toxicity of advanced radiotherapy (ART) techniques, including intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), and stereotactic…
- Conditions
- Malignant Tumor, Benign Neoplasm, Parkinson Disease, Trigeminal Neuralgia
- Trial name
- 25-ART-HSR (NCT07894900)
- Testing
- Advanced radiotherapy techniques
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorder
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.
CDK13 related disorder is mainly characterised by developmental delay (DD) and intellectual disability (ID), ranging from mild to severe, and malformation syndrome.
- Trial name
- CDK13 (NCT04382573)
- Testing
- Epigenetic signatures
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Temporomandibular Joint Ankylosis, Facial Asymmetry
Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity
Hypothesis：Computer-aided design virtual mandibular position is feasible for costochondral graft growing and occlusion stabilizing in the one-stage treatment of children temporomandibular joint ankylosis (TMJA) or condyle absence…
- Trial name
- NCT03845088
- Testing
- temporomandibular jont reconstruction with costochondral transplantation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking University
Deformity of Face
Postoperative Follow up After Head and Face Reconstructive Surgeries
In this observational follow-up study, patients with type III-IV head and face soft tissue deformities/defects following reconstructive surgeries will be asked to fill out 3 questionnaires, either through phone calls or video…
- Trial name
- NCT04405687
- Testing
- Severe head and face deformity reconstructive surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Facial Angiofibromas
Topical Everolimus in Patients With Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder characterized by the development of hamartomas in several organs (e.g. brain, heart, kidney, liver, lung), and skin in more than 90% of cases.
- Trial name
- EVEROST (NCT02860494)
- Testing
- Everolimus
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Angiofibroma of Face, Tuberous Sclerosis
Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex
The objective of this study is to evaluate the safety and efficacy of sirolimus (0.2% and 0.4% formulations) and its vehicle when applied topically once daily for 12 weeks for the treatment of cutaneous angiofibromas in pediatric…
- Trial name
- NCT03363763
- Testing
- Sirolimus 0.2%, Sirolimus 0.4%
- Where
- 8 sites in United States, China
- Volunteers
- 24 people
- Sponsor
- Aucta Pharmaceuticals, Inc
Dermatitis, Atopic
Protopic Ointment in Adult Atopic Eczema of the Face
Patients with facial atopic eczema and a poor response to topical corticosteroid applied either Protopic or Fluticasone ointment twice a day for 3 weeks.
- Trial name
- NCT00690105
- Testing
- tacrolimus 0.1%, fluticasone 0.005 %
- Where
- France
- Volunteers
- 577 people
- Sponsor
- Astellas Pharma Inc
Skin Pigmentation Over Contour Deformities of Face, Trauma, Rhomberg Disease
Long Term Effects on Skin Hyper Pigmentation With and Without Mesenchymal Stem Cell Enriched Adipose Tissue Grafting for "Contour Deformities With Pigmentary Changes on Face"
MSCs one injected along with fat, regulate pigmentation over the contour defects of face
- Trial name
- MSCs (NCT03564808)
- Testing
- MSC
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Class III Malocclusion, Skeletal Malocclusion
Comparison of Skeletal Anchorage Versus Conventional Tooth-Borne Face Mask Therapy Following the Alt-RAMEC Protocol
This study investigated two different methods of maxillary protraction in growing patients with skeletal Class III malocclusion characterized by maxillary deficiency.
- Conditions
- Class III Malocclusion, Skeletal Malocclusion, Maxillary Deficiency
- Trial name
- MiniFM (NCT07279662)
- Testing
- Skeletal Anchorage Supported Maxillary Protraction, Tooth-Borne Maxillary Protraction Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Murat Kaan Erdem
Molar-Incisor Hypomineralization (MIH)
Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor Hypomineralization
This randomized clinical trial compares Er:YAG laser-assisted and conventional rotary cavity preparation in children aged 6-12 years with molar-incisor hypomineralization.
- Trial name
- NCT07759739
- Testing
- Er:YAG Laser-Assisted Cavity Preparation, Conventional Rotary Cavity Preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ege University
Atopic Dermatitis
Ruxolitinib Cream in Participants With Facial and/or Neck Atopic Dermatitis Involvement
This is a randomized, double blind, vehicle controlled Phase 2 study with a 4-week open label extension in adolescent and adult participants with atopic dermatitis and head and/or neck involvement.
- Trial name
- NCT05127421
- Testing
- Ruxolitinib cream, Vehicle
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Incyte Corporation
Orthognathic Surgery, Maxillofacial Abnormalities
Study Evaluating the Performance and Safety of Global D Implants Indicated for Orthognathic Surgery
This study is set up within the framework of the European Union regulation 2017/745 on medical devices. Its objective is to confirm the performance and safety of the Global D implants (ORTRAUTEK® and MINITEK®) used for…
- Conditions
- Orthognathic Surgery, Maxillofacial Abnormalities, Maxilla Fracture
- Trial name
- CMF-ORTHO (NCT05271383)
- Testing
- Orthognathic surgery using Global D's implants.
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Global D
Craniofacial Abnormalities
FACE.S-4-KIDS : A Deep Phenotyping Database of Craniofacial Anomalies During Development With 4 Pilot Projects
FACE.S-4-KIDS is an ambitious database project addressing the scientific question of the variable expression of craniofacial disorders in humans, to reach a sound clinical management (diagnosis, prognosis), and the establishment…
- Trial name
- FACES-4-KIDS (NCT07422454)
- Where
- France
- Volunteers
- 3,100 people
- Sponsor
- Imagine Institute
Plagiocephaly, Craniosynostosis
Hanger Helmet Study
The purpose of this study is to examine a group of patients requiring helmet therapy (either patients with plagiocephaly or post-surgical patients) to compare outcomes of infants treated with the Hanger helmet (Hanger, Inc.) to…
- Trial name
- NCT02561728
- Testing
- Hangar Helmet, P-Pod Helmet
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Head and Neck Cancer, Radiotherapy Side Effect
DENTOFACIAL-PBT Stage 2 - Feasibility Study
What is the health problem? Proton beam therapy (PBT), a type of radiotherapy treatment, can be especially beneficial to children and teenagers with cancer.
- Conditions
- Head and Neck Cancer, Radiotherapy Side Effect, Adverse Effect of Radiation Therapy, Childhood Cancer
- Trial name
- NCT07057284
- Testing
- Orthopantomogram (or a set of Lateral Oblique Radiographs)
- Where
- 2 sites in United Kingdom
- Volunteers
- 255 people
- Sponsor
- Manchester University NHS Foundation Trust
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health