Clinical trials: Developmental Disorder
Autism
Folate Rechallenge
New evidence suggests that autistic disorder (AD) may be associated with abnormalities in folate metabolism, which is a process that affects genetic expression by facilitating the formation of methyl donors for DNA methylation.
- Trial name
- NCT00672360
- Testing
- Folic acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Autism
Effects of Hyperbaric Oxygen Therapy on Children With Autism
PURPOSE The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism spectrum disorder. HYPOTHESIS 1.
- Trial name
- NCT00406159
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thoughtful House
Autism Spectrum Disorder
Interest of Oxytocin as an Adjuvant Treatment of Psycho-educational Measures in Challenging Behaviors in Children With Autism Spectrum Disorders and Moderate to Severe Intellectual Disability: Feasibility and Safety Study.
The investigation team propose in this study to specifically evaluate the feasibility of using oxytocin in the form of an intranasal spray in a specific population of children with autism spectrum disorder and intellectual…
- Trial name
- OT-DEFI (NCT05864508)
- Testing
- Oxytocin nasal spray
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Relation, Mother-Child, Family Conflict
Children's Learning Centers Group FNI
The purpose of this study is to compare the effects of Family Nurture Intervention in a mother-child group setting with a Standard Children's Learning Center (CLC) Program for preschool-aged children (ages 2-4.5).
- Conditions
- Relation, Mother-Child, Family Conflict, Emotional Disturbances, Behavior Problem
- Trial name
- NCT03908268
- Testing
- Family Nurture Intervention (FNI), Standard Children's Learning Center (CLC) Program
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV, AIDS
The DC Cohort Longitudinal HIV Status Neutral Study
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for patients diagnosed with Human Immunodeficiency Virus/Acquired Immune…
- Trial name
- DC Cohort (NCT01206920)
- Where
- 14 sites in United States
- Volunteers
- 19,000 people, healthy volunteers welcome
- Sponsor
- George Washington University
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Marfan Syndrome
A Randomized, Open-label, LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With Marfan Syndrome
To assess the efficacy of angiotensin II receptor blocker, Losartan, to prevent progressive dilation of aortic root in patients with Marfan syndrome.
- Trial name
- MFS (NCT00651235)
- Testing
- Losartan and Atenolol or Propranolol, Atenolol or Propranolol
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- National Taiwan University Hospital
Viral Hepatitis
Seroepidemiology of Viral Hepatitis in Hong Kong
Immunisation policies have strong influences on the epidemiology of hepatitis A and B infection. In Hong Kong, vaccines against both viruses have been available through different channels and programmes in the past 3 decades.
- Trial name
- NCT04371276
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,888 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obesity Associated With Defects in Leptin-melanocortin Pathway
Open-Label Extension Study of Setmelanotide
This is an open-label extension study designed to evaluate the long-term safety and tolerability of continued setmelanotide treatment in male and female patients ≥2 years of age who have completed or transitioned from a previous…
- Trial name
- NCT06596135
- Testing
- Setmelanotide
- Where
- 13 sites in United States
- Volunteers
- 28 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Environmental Exposures, Other Pregnancy With Abortive Outcome
The China-Anhui Birth Cohort Study (C-ABCS)
The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development.
- Conditions
- Environmental Exposures, Other Pregnancy With Abortive Outcome, Birth Defects, Children Development
- Trial name
- NCT02391610
- Testing
- No intervention
- Volunteers
- 16,766 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Latent Tuberculosis Infection, Tuberculosis
Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis
This is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease.
- Trial name
- NCT01622140
- Where
- 10 sites in United States
- Volunteers
- 21,334 people
- Sponsor
- Centers for Disease Control and Prevention
Autism Spectrum Disorder (ASD)
Coaching and Leadership in Autism Support Settings
Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based practices: 1) an intervention gap characterized by limited availability of evidence-based practices…
- Trial name
- CLASS (NCT07276750)
- Testing
- RUBIES, HELM, Educator Psychoeducation
- Where
- United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Preterm Birth, Prenatal Care Late
This Study Was to Investigate the Efficacy of Fetal Right Heart Doppler Findings in Determination of Pulmonary Maturity
Objective: The aim of this study was to investigate the efficacy of fetal right heart doppler findings in determination of pulmonary maturity.
- Conditions
- Preterm Birth, Prenatal Care Late, Preterm Labor
- Trial name
- NCT04296591
- Testing
- fetal heart doppler findings
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Brain Tumor
Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors
This study will examine the safety and effectiveness of treating brain tumors in children with a continuous infusion of phenylbutyrate.
- Trial name
- NCT00006450
- Testing
- Phenylbutyrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder
A Family Study of Copy Number Variations in Patients With Autism Spectrum Disorder
This 3-year proposal is a family-based cohort study to establish a representative sample of probands with ASD and their parents with well-characterized environmental, clinical phenotypes, endophenotypes, and genetic data to…
- Trial name
- NCT02228876
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder, Neurofibromatosis 1
From Molecules to Cognition: Inhibitory Mechanisms in ASD and NF1
This study aims to investigate synaptic physiology and behavioral inhibition in patients with NF1 and ASD and to answer whether inhibitory deficits at these levels are modulated by lovastatin.
- Trial name
- ASD/NF1inhib (NCT03826940)
- Testing
- Lovastatin 60 MG
- Where
- Portugal
- Volunteers
- 16 people
- Sponsor
- University of Coimbra
Autism, Autism Spectrum Disorder
Placebo-Controlled Study of Terpenes-Enriched Cannabis Oil T1/C28 for Children With Autism
The goal of this clinical trial is to determine whether cannabidiol (CBD, 28%) combined with terpenes and a small amount of THC (1%) can help reduce symptoms of autism, and to evaluate the safety of this treatment.
- Trial name
- TECA (NCT07199218)
- Testing
- Terpenes-Enriched CBD-Predominant Oil, Terpenes-Enriched CBD Oil (THC-Free)
- Where
- Israel
- Volunteers
- 78 people
- Sponsor
- Bazelet Nehushtan LtD.
Developmental Coordination Disorder
Tai Chi-muscle Power Training for Primary School Children With Developmental Coordination Disorder
Objectives: To compare the effectiveness of Tai Chi-muscle power training (TC-MPT), Tai Chi (TC) alone, muscle power training (MPT) alone, and usual care (as a control) for improving the limits of stability (LOS) of balance…
- Trial name
- NCT03598478
- Testing
- TC-MPT, TC, MPT
- Where
- Hong Kong
- Volunteers
- 156 people
- Sponsor
- The University of Hong Kong
CNS Germinoma, CNS Tumor
Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors
<Purpose of the Research> Primary Establishing an Asian consortium to establish a database of pediatric CNS tumors in the prospective manner The target disease of this research focuses on pediatric tumors, and initially the…
- Conditions
- CNS Germinoma, CNS Tumor, Asian Consortium
- Trial name
- NCT05982691
- Testing
- Radiation Therapy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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