Clinical trials: Digestive System Neoplasm
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 3
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER3 (NCT05587725)
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Monash University
Colorectal Cancer, Refractory Colorectal Cancer
Fruquintinib in Refractory Metastatic Colorectal Cancer: A Real-world Study
Fruquintinib is an oral tyrosine kinase inhibitor (TKI), which improves progression-free survival (PFS) and overall survival (OS) in patients with refractory metastatic colorectal cancer (mCRC).
- Conditions
- Colorectal Cancer, Refractory Colorectal Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT06202417
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Liver Tumors
Prevention of Liver Damage During Liver Surgery
Liver damage as a consequnce of ischemia (I) and reperfusion (R) is known to harm the liver and could hence be a critical factor of the postoperative outcome of patients undergoing liver surgery.
- Trial name
- LTR (NCT00845689)
- Testing
- adenosine, Liver resection
- Sponsor
- Ludwig-Maximilians - University of Munich
Lynch Syndrome, Recurrent Uterine Corpus Carcinoma
Biomarkers in Samples From Patients With Endometrial Cancer
This research study is studying biomarkers in samples from patients with endometrial cancer. Studying samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify…
- Conditions
- Lynch Syndrome, Recurrent Uterine Corpus Carcinoma, Stage I Uterine Corpus Cancer, Stage II Uterine Corpus Cancer
- Trial name
- NCT01199250
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Sponsor
- Gynecologic Oncology Group
Sarcoma, Oral Mucositis
Caphosol in Sarcoma Patients With Mucositis
The goal of this clinical research study is to find out if Caphosol® (calcium phosphate) mouthwash is more effective than a baking soda solution at preventing and treating mucositis, in patients with sarcoma who are to be treated…
- Trial name
- NCT00965172
- Testing
- Caphosol, Baking Soda
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Anastomotic Leak, Anastomotic Leak Large Intestine
Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinical Trial
This study aim to determine if a different surgical technique could result in a lower anastomotic leak rate. The two techniques are equally used around the world and well described by the international literature but this is the…
- Conditions
- Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Colon Cancer
- Trial name
- LOTHVEIN (NCT05411783)
- Testing
- Low tie of IMV
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- San Carlo di Nancy Hospital
Stomach Neoplasms
Lifestyle Intervention for Prevention of Gastric Neoplasm
The purpose of this study is to determine whether positive lifestyle interventions (diet modification and smoking cessation) are effective in the prevention of gastric pre-cancer and cancer occurrences and reccurence of gastric…
- Trial name
- NCT02679495
- Testing
- Active measures of lifestyle modification
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong University
Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders
Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
The primary objective of this protocol is to provide expanded access to tabelecleucel to participants with Epstein-Barr virus-associated diseases and malignancies for whom there are no other appropriate therapeutic options, and…
- Conditions
- Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders, EBV+ Associated Lymphoma, EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
- Trial name
- NCT02822495
- Testing
- tabelecleucel
- Sponsor
- Atara Biotherapeutics
Colorectal Cancer
Natural Orifice Transluminal Endoscopic Surgery for Colorectal Cancer
The purpose of this study is to assess different hybrid natural orifice transluminal endoscopic surgery techniques in management of colorectal cancer as regard: feasibility of the technique, short term oncologic outcome and…
- Trial name
- NOTES (NCT02549456)
- Testing
- natural orifice specimen extraction, Laparoendoscopic resection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Hematopoietic and Lymphoid Cell Neoplasm
Fecal Microbiota Transplantation for Steroid Resistant/Dependent Acute GI GVHD
The purpose of this study is to evaluate the efficacy and safety of fecal microbiome transplantation in patients with steroid resistant/dependent acute gastrointestinal graft-versus-host disease (GVHD).
- Trial name
- FEMITGIGVHD (NCT03812705)
- Testing
- fecal microbiome transplantation
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colonic Neoplasms, Rectal Neoplasms
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum - International Study
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum
- Trial name
- NCT00537901
- Testing
- First-Line Bevacizumab and Chemotherapy, Bevacizumab
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Colorectal Cancer
Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003422
- Testing
- fluorouracil, leucovorin calcium, adjuvant therapy
- Where
- 9 sites in Canada, United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- Medical Research Council
Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
Pancreatic Cancer Recurrence in the Netherlands
The aim of this nationwide, observational cohort study is to evaluate current surveillance strategies after primary resection of pancreatic ductal adenocarcinoma (PDAC) in the Netherlands, with regard to the detection, treatment…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer, Pancreas Cancer, PDAC
- Trial name
- NCT04605237
- Where
- Netherlands
- Volunteers
- 1,750 people
- Sponsor
- UMC Utrecht
Colorectal Cancer
Carbohydrate Antigen 19-9 in Colorectal Cancer
4,972 patients who underwent surgery for primary CRC between January 2004 and December 2015 at Seoul National University Hospital were retrospectively reviewed.
- Trial name
- NCT04999072
- Testing
- Colectomy for colon cancer
- Where
- South Korea
- Volunteers
- 4,972 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
Assessment of Glypican 3 as Apredictive Marker in Colorectal Cancer Patients
Evaluation Of Glypican 3 in serum of colorectal cancer patients . Correlation between Glypican 3 and clinicopathological characteristics of colorectal cancer .
- Trial name
- NCT04728139
- Testing
- glypican 3
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hepatocellular Carcinoma
Impact of "Teaching the Teachers" Concept on Global Education and Application of Hepatocellular Carcinoma Diagnosis Guidelines
This study evaluates a concept called 'Teaching the Teachers' and whether it is helpful in disseminating guidelines on the national and international levels.
- Trial name
- NCT05143619
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Gastrointestinal Bleeding, Gastrointestinal Neoplasms
A Disposable Endoscopic Closing Device Used for the Closure of Gastrointestinal Tissue
This clinical trial employs a prospective, multicenter, randomized, single-blind, parallel-controlled, non-inferiority design with a positive comparator device.
- Trial name
- NCT07727564
- Testing
- disposable endoscopic closing device, metal clips, or metal clips in combination with nylon loops
- Volunteers
- 60 people
- Sponsor
- Jiangsu Vedkang Medical Science and Technology Co., Ltd
Colorectal Cancer, Inflammation
Reducing Metabolic Dysregulation in Dyads
This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening.
- Conditions
- Colorectal Cancer, Inflammation, Nutrition Related Cancer
- Trial name
- REMEDY (NCT06117241)
- Testing
- IMAGINE HEALTHY
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastric Cancer
Evaluation of Double Tract Reconstruction After Total Gastrectomy in Patients With Gastric Cancer
The purpose of this study is to evaluate the double tract reconstruction after total gastrectomy in patients with gastric cancer.
- Trial name
- NCT00746161
- Testing
- Reconstruction after total gastrectomy
- Where
- Japan
- Volunteers
- 44 people
- Sponsor
- Wakayama Medical University
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