Clinical trials: Dobutamine
Shock
Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period
Haemodynamic insufficiency after birth is seen commonly in babies born prematurely and is associated with adverse outcomes. In current clinical practice, a combination of blood pressure and clinical signs is used to guide…
- Trial name
- NeoCirc-001 (NCT03311178)
- Testing
- Dobutamine
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Coronary Artery Disease
Hemodynamic Forces at Rest and Stress vs. Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
Stress perfusion CMR has recently considered as one of the methods of choice for establishing the diagnosis of CAD based on its high diagnostic accuracy, lack of ionizing radiation as well as its ability to simultaneously assess…
- Trial name
- CMR (NCT04247698)
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Assiut University
Dobutamine, Milrinone , Pediatrics , Low Cardiac Output
Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital
The aim of the study is to detect wither dobutamine or milrinone have a privilege in the management of low cardiac output pediatric patients over the other.
- Trial name
- NCT05999487
- Testing
- Dobutamine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Hemodynamic Instability
Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns
Low systemic flow as measured by Doppler-echocardiography has been associated with poor neurological outcome. Yet, it has not been systematically evaluated whether the treatment of this hemodynamic condition is beneficial or not.
- Trial name
- NCT01605279
- Testing
- Dobutamine
- Where
- Spain
- Volunteers
- 127 people
- Sponsor
- Adelina Pellicer
Coronary Disease
Comparison of Echocardiographic Techniques in Diagnosis of Coronary Artery Disease
This study is designed to compare two different echocardiographic techniques in the evaluation of heart disease (coronary artery disease).
- Trial name
- NCT00001889
- Testing
- Myocardial contrast echocardiography, Stress echocardiography with dobutamine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Right Ventricular Contractile Reserve in HF
Right ventricle dysfunction and pulmonary hypertension are related to a worse prognosis in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) or with normal left ventricular ejection fraction…
- Trial name
- RISE-HF (NCT05797584)
- Testing
- Dobutamine, Passive leg raising
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Arterial Hypotension
Dopamine Versus Dobutamine for Treatment of Arterial Hypotension in Term and Preterm Neonates
The purpose of this study is to examine the effects of Dobutamine as compared to Dopamine in term and preterm neonates with arterial hypotension on cerebral and renal oxygenation, fractional tissue oxygen extraction, mean…
- Trial name
- NCT01427686
- Testing
- Dobutamine, Dopamine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Ulm
Oral Cancer, Head and Neck Cancer
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck.
- Conditions
- Oral Cancer, Head and Neck Cancer, Free Flap, Hypotension
- Trial name
- Free4Flow (NCT01418118)
- Testing
- Epinephrine, Norepinephrine, Dobutamine
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford University Hospitals NHS Trust
Aortic Valve Insufficiency, Mitral Valve Insufficiency
Investigation of Heart Function in Patients With Heart Valve Defects
In this study researchers plan to perform a diagnostic test called transesophageal echocardiography in order to see and record the movement and function of the heart.
- Trial name
- NCT00001314
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pediatric Cardiac Surgery
Influence of Inotropic Choice on Morbidity and Mortality in Complex Pediatric Heart Surgery
Our study is based on the observation that management of the cardiopulmonary by-pass withdrawal in pediatric heart surgery is quite variable between medical teams.
- Trial name
- CHUBpedCSino (NCT04380181)
- Testing
- dobu
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Brugmann University Hospital
Circulatory Failure
NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
1 in 1000 babies are born suffering from a lack of oxygen. This is known as hypoxic ischemic encephalopathy (HIE). Infants with this condition can suffer multiple organ problems.
- Trial name
- NCT02051894
- Testing
- Dobutamine
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Right Ventricular Dysfunction
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction.
- Trial name
- TOF-Cond (NCT00557934)
- Testing
- dobutamine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Myocardial Ischemia
Assessment of HyperQ Signal for Detecting Ischemia During Dobutamine Stress ECG
The purpose of the study is to verify the ability of the HyperQ signal to detect Dobutamine induced Ischemia. The gold standard for ischemia will be the results of Angiography if performed, or Echocardiographic imaging, which was…
- Trial name
- NCT00310622
- Testing
- HyperQ Signal recording
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- BSP Biological Signal Processing Ltd.
Kawasaki Disease, Heart Disease
Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging
The present study is designed to: 1. investigate the safety and efficacy of Real time myocardial echocardiography (RT-MCE) in adolescents and adults ages 12-50 with congenital and acquired congenital heart disease 2.
- Trial name
- ECHOBIKE (NCT00861848)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Circulatory Failure
NeoAdapt 2: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency
Circulatory failure can affect up to 50% of premature infants that are admitted to neonatal intensive care. This can be because their heart muscle is not developed enough to send blood to vital organs such as the brain.
- Trial name
- NCT02051855
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Heart Failure, Ventricular Dysfunction, Left
Electrical Stimulation Improves Exercise Tolerance in Patients With Advanced Heart Failure on Continuous Dobutamine Use
The purpose of this study is to determine whether neuromuscular electrical stimulation can improve exercise tolerance for patients with heart failure and continuous dobutamine use in a hospital.
- Trial name
- NCT02668419
- Testing
- Neuromuscular Electrical Stimulator, Physical Therapy Session
- Where
- Brazil
- Volunteers
- 49 people
- Sponsor
- Federal University of São Paulo
Hypoxic-ischemic Encephalopathy (HIE)
The PROTECT-HIE Pilot Trial
Some babies experience a lack of oxygen and blood flow around the time of birth. This can lead to a serious condition called hypoxic-ischemic encephalopathy (HIE), which can injure the brain and other organs, including the heart.
- Trial name
- PROTECT-HIE (NCT07406477)
- Testing
- Dobutamine, TnECHO
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Infant, Premature, Diseases, Circulatory and Respiratory Physiological Phenomena
Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants
Single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (SVC) flow, in infants below 33 weeks' gestation during…
- Trial name
- NeoCirc-002 (NCT06878742)
- Testing
- Intravenous dobutamine 5 mcg/kg/min, Intravenous dobutamine 7.5 mcg/kg/min, Intravenous dobutamine 10 mcg/kg/min
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz