Clinical trials: Effects of Chemotherapy
Liver Cancer, Ototoxicity
Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SIOPEL6 (NCT00652132)
- Testing
- cisplatin, sodium thiosulfate
- Where
- 16 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Birmingham
B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma
This phase III trial compares the effect of adding levocarnitine to standard chemotherapy versus (vs.) standard chemotherapy alone in protecting the liver in patients with leukemia or lymphoma.
- Conditions
- B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Lymphoblastic Lymphoma
- Trial name
- NCT05602194
- Testing
- Biospecimen Collection, Calaspargase Pegol, Levocarnitine
- Where
- 228 sites in United States, Canada
- Volunteers
- 440 people
- Sponsor
- Children's Oncology Group
Childhood Cancers, Pediatric Oncology
Parent-Child Mandala Painting During Chemotherapy
This randomized controlled trial aims to evaluate the effects of a parent-child mandala painting intervention conducted during the chemotherapy process on caregiver burden, psychological well-being, and child fear and pain levels…
- Trial name
- NCT07363005
- Testing
- Parent-Child Mandala Painting Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Yuzuncu Yil University
Chemotherapy Effect, Oncology
Modified Cephalica Venous Access Port Implantation
As long term totally implantable central venous access (TIVAPS) was increasingly needed in cancer patient, some modified techniques were introduced to improved the outcome and safety of the port implantation.
- Trial name
- NCT04348487
- Testing
- Modified cephalica venous access
- Where
- Indonesia
- Volunteers
- 3 people
- Sponsor
- Udayana University
Leukemia
Peppermint Inhalation Versus Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia
Clinical trials was used to compare the effect of peppermint inhalation and Swedish massage on chemotherapy induced-nausea and vomiting in children with leukemia.
- Trial name
- NCT06095726
- Testing
- Peppermint Inhalation, Swedish Massage
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Alexandria University
Nurse's Role
The Effect of Music Intervention on Anxiety, Fear, and Pain in Pediatric Patients Receiving Intrathecal Chemotherapy
Intrathecal chemotherapy is often used to prevent the spread of cancer to the central nervous system in pediatric patients and is one of the most invasive procedures.
- Trial name
- NCT06424587
- Testing
- Music intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ondokuz Mayıs University
Pain
The Effect of Distraction With a Kaleidoscope on the Level of Perceived Pain During Blood Sampling in Children
This experimental study aimed to determine the effect of distracting children with a kaleidoscope during blood sampling on their perception of pain during the procedure and to increase and improve the quality of evidence for the…
- Trial name
- NCT06352021
- Testing
- kaleidoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- İlknur KAHRİMAN
Pain, Anxiety
The Effect of Mandala on Nausea, Vomiting, Pain and Anxiety in Chemotherapy Patients
To determine the effect of mandala art therapy (coloring) on nausea, vomiting, pain and anxiety in children receiving outpatient chemotherapy.
- Trial name
- NCT06508632
- Testing
- Mandala group
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Cukurova University
Sleep Wake Disorders
Holy Qur'an Versus Music Sound on Sleep Quality in Children Undergoing Chemotherapy
This randomized controlled trial aims to evaluate the effect of listening to Holy Qur'an recitation compared with music sound on sleep quality among children aged 6 to 10 years undergoing chemotherapy.
- Trial name
- QMS-Sleep (NCT07621861)
- Testing
- Music Therapy, Holy Qur'an Recitation
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Rawand Shafeeq Ali
Peripheral Neuropathy
Effect of Shock Wave In Reducing Chemotherapy- Induced Peripheral Neuropathy In Adult and Pediatric Tumors Patients
This study aimed to assess the efficacy of shock wave in reducing Chemotherapy- Induced Peripheral Neuropathy in adult and pediatric tumors patients.
- Trial name
- NCT05111730
- Testing
- The Shock wave Therapy.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- South Valley University
HIV Infections
Safety and Effectiveness of Treating HIV-Positive Patients With an HIV Vaccine (Remune)
The purpose of this study is to see if giving HIV-positive patients an HIV vaccine plus anti-HIV drugs can help lower HIV levels in the blood (viral load).
- Trial name
- NCT00005001
- Testing
- HIV-1 Immunogen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Agouron Pharmaceuticals
Breast Cancer Females, Oncology
Effects of a Group Versus Individual Cognitive Training Program on Chemotherapy-induced Cognitive Impairment (Chemobrain) in Breast Cancer Patients Undergoing Active Treatment
Introduction: The significant improvement in breast cancer survival, largely attributable to biomedical and technological progress, makes it increasingly necessary to investigate the secondary effects linked to this pathology.
- Trial name
- NCT07165912
- Testing
- Health Education Program, Individual Cognitive Training Program, Group training program
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- University of Salamanca
Cancer
Health Literacy Multi-media Study
Cancer patients are presented with a lot of information about their diagnosis and different treatment options, which can be confusing.
- Trial name
- NCT02999529
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Cryotherapy Effect
Cryoprotection of Chemotherapy-induced Oral Mucositis After Autologous Stem Cell Transplantation, a Randomized Study
This study evaluates, among study patients with lymphoma or myeloma undergoing autologous SCT, whether cooling oral mucosa with a cooling device compared with ice cubes/crushed ice or ice pop succeeds in reducing the degree of…
- Trial name
- NCT03203733
- Testing
- Cooral™, cryotherapy
- Where
- 5 sites in Norway, Sweden
- Volunteers
- 182 people
- Sponsor
- Uppsala University
HIV Infections
A Study to Compare the Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients
The purpose of this study is to examine how the immune systems of HIV-infected patients react to 2 anti-HIV drug combinations.
- Trial name
- NCT00002448
- Testing
- Ritonavir, Efavirenz, Saquinavir
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hoffmann-La Roche
Effect of Drugs, Progression
Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma
Results of previous study showed high objective response but short-term activity of anti-angiogenesis tyrosine kinase inhibitors in advanced osteosarcoma.
- Conditions
- Effect of Drugs, Progression, Pediatric Cancer
- Trial name
- NCT04044378
- Testing
- Famitinib, Ifosfamide, Camrelizumab
- Where
- China
- Sponsor
- Peking University People's Hospital
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Neoplasms, Peritoneal Neoplasms
PIPAC for Peritoneal Metastases of Colorectal Cancer
This is multicentre, open-label, single-arm phase II study that investigates the feasibility, safety, tolerability, preliminary efficacy, costs, and pharmacokinetics or repetitive electrostatic pressurised intraperitoneal aerosol…
- Conditions
- Colorectal Neoplasms, Peritoneal Neoplasms, Appendiceal Neoplasms, Peritoneal Carcinomatosis
- Trial name
- CRC-PIPAC (NCT03246321)
- Testing
- repetitive ePIPAC-OX
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Koen Rovers
Osteosarcoma, Spindle Cell Sarcoma of Bone
Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?
Methotrexate is one of the most effective chemotherapy drugs in the treatment of osteosarcoma and some other types of bone sarcoma which are treated the same way as osteosarcoma.
- Trial name
- NCT02022358
- Testing
- Glucarpidase, Methotrexate, Folinic Acid
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Cancer, Chemotherapy-induced Nausea and Vomiting
Designed Music Narratives for the Reduction of Side Effects of Chemotherapy in Children (7-12 Years) With Cancer
The purpose of this study is to determine whether a specially-designed music-narratives are effective in reducing side effects of chemotherapy in 7- to 12-year-olds with cancer.
- Conditions
- Cancer, Chemotherapy-induced Nausea and Vomiting, Effects of Chemotherapy
- Trial name
- NCT02583139
- Testing
- Designed Music Narratives
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- University of Aarhus