Clinical trials: Embryo
Child Development, Endometrial Preparation
Development of IVF/ICSI Children Born From Different Endometrial Preparation Protocols
The efficacy and safety of endometrial preparation regimens remain controversial. In the most recent meta-analysis, using natural and modified natural cycle protocol to prepare the endometrium in frozen embryo transfer resulted…
- Trial name
- MONARTBABIES (NCT05502770)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
De Novo Mutation, Preimplantation Genetic Testing
Optimized PGT-M Strategy for Patients With No Proband
The clinical practice of PGT-M for monogenetic disease usually adopted a double-checking strategy, which detect the mutation by Sanger sequencing and meantime construct haplotypes using the DNA sample of the proband so as to…
- Conditions
- De Novo Mutation, Preimplantation Genetic Testing, Without Proband
- Trial name
- NCT06722313
- Testing
- Gametes (sperm or second polar bodies, MI eggs) or arrested embryos were reserved for identification of a proband
- Where
- China
- Volunteers
- 5 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, in Vitro Fertilization
Ultrasound Guided Embryo Transfer: Abdominal Versus Transvaginal, a RCT
Ultrasound (US) guided embryo transfer (ET) appears to improve pregnancy outcomes in IVF-ET. Most reports are done using a transabdominal (TAS) approach, in contrast to a transvaginal ultrasound (TVS) which does not require a…
- Trial name
- NCT00682071
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Male Infertility
Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?
There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical…
- Trial name
- NCT06476379
- Testing
- Testicular sperm extraction (TESE), Ejaculate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ganin Fertility Center
Rabies Post-exposure Prophylaxis
Purified Rabies Vaccine for Human Use (Chick-embryo Cell)
Evaluate the immunogenicity and safety of rabies vaccine given in a post-exposure prophylaxis regimen to healthy children and adults aged 10-60 years.
- Trial name
- NCT00345319
- Testing
- rabies vaccine
- Where
- China
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Adenomyosis, IVF
Ambispective Study to Assess the Effect of Pretreatment With a Levonorgestrel-Releasing Intrauterine System Versus Oral Progestin
The study participants' relevant medical records will be collected and reviewed for the retrospective subjects and after obtaining informed consent for the prospective subjects.
- Trial name
- NCT05152667
- Testing
- levonorgestrel-releasing intrauterine device (LNG-IUS)
- Where
- Egypt
- Volunteers
- 354 people
- Sponsor
- Wael Elbanna Clinic
Infertility
Frozen Embryo Donation Study
The purpose of this study is to improve patient understanding of and interest in donating frozen embryos resulting from in vitro fertilization (IVF) to others undergoing infertility treatment.
- Trial name
- FREDS (NCT01883934)
- Testing
- Enhanced clinic-based support/counseling, Control
- Where
- United States
- Volunteers
- 3,568 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Infertility, Female, Sexual Intercourse
Sex or no Sex: That is the Question.
This study aims to evaluate the impact of sexual intercourse and orgasm in the 72 hrs following embryo transfer of blastocysts on the clinical pregnancy rate.
- Trial name
- NCT04880590
- Testing
- Sex intercourse
- Where
- Spain
- Volunteers
- 412 people
- Sponsor
- Fundación Santiago Dexeus Font
IVF, Infertility Treatment
Biomarkers of Endometrial Receptivity
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity.
- Conditions
- IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer
- Trial name
- BIOMER (NCT04619524)
- Testing
- Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos
- Where
- 3 sites in Czechia
- Volunteers
- 476 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Abnormal Fertilization, Infertility
Outcomes of Embryos Created From Abnormally Fertilized Oocytes
The purpose of this study is to retrospectively analyze data from multiple clinics in a fertility network on embryos that were created from abnormally fertilized oocytes (AFO) including the rate of transfers and any clinical…
- Trial name
- NCT07666243
- Volunteers
- 92 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility
Human MATER and Idiopathic Infertility
Approximately 15 percent of couples experience infertility, yet no abnormalities can be detected in the man or the woman. In a number of couples, their embryos unexpectedly slow down growth or stop growth completely.
- Trial name
- NCT00361816
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility (IVF Patients), Infertility Female
Norethindrone Impact on Receptiva Outcomes
This retrospective study aims to evaluate pregnancy outcomes in patients with a positive BCL6 test (ReceptivaDx, who were treated with either norethindrone acetate or Depo Lupron prior to embryo transfer.
- Trial name
- NIRO (NCT07134920)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Inception Fertility Research Institute, LLC
to Evaluate the Feasibility and Accuracy of Using cfDNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for PGD
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
This study aims to evaluate the feasibility and accuracy of using cfDNA analysis of spent embryo culture media as a non-invasive approach for PGD. Specifically, the objectives of the study are: 1.
- Trial name
- NCT07076719
- Testing
- Trophectoderm (TE) Biopsy, Non-invasive Preimplantation Genetic Diagnosis
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Sohag University
Infertility
Development of a Screening Tool for Difficult Embryo Transfers
This study aims to investigate the accuracy of a proposed screening tool in identifying difficult embryo transfers (ETs) without doing a mock ET.
- Trial name
- NCT05701072
- Testing
- Oocyte Pick Up, Embryo Transfer
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- ART Fertility Clinics LLC
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Embryo Hypoxia
Influence of Manipulation of Oocytes and Embryos in Low Oxygen Tension on Assisted Reproduction Technology Outcome
Nowadays, most assisted reproduction laboratories attempt to maintain as much as possible ex vivo culture conditions comparable to those in vivo.
- Trial name
- NCT04424784
- Testing
- 5% O2
- Where
- China
- Volunteers
- 1,160 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Fertility Disorders
ASA 81 mg vs 162 mg During Frozen Embryo Transfer (FET)
The use of low dose aspirin is recommended for high risk patients to reduce the risk of pre-eclampsia, placental abruption and antepartum hemorrhage.
- Trial name
- NCT06128395
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Infertility
Outcome of Embryos Transferred After Initial Chaotic Results on PGT-A
This is a retrospective review of treatment outcomes from fertility clinics in The Prelude Network who have used Igenomix for PGT-A and have transferred embryos with initial chaotic results, regardless if re-biopsy was performed.
- Trial name
- NCT06373237
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Implantation Failure
ISM1 Versus EmbrioGen Media for Embryo Culture With Previous Failure Implantation in ART Treatments
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689454
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi