Clinical trials: Endocrine System Disorder
Type 1 Diabetes Mellitus
Carb Counting vs. Simplified Qualitative Meal-Size Estimation
The goal of this study is to compare qualitative meal-size estimation to accurate carb counting in adolescents with Type One Diabetes using all available AID (Automated Insulin Delivery) systems.
- Trial name
- NCT06687434
- Testing
- accurate carb counting, Simplified qualitative meal size estimation
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 2
GLucobay M - Evaluation Of Safety and Effectiveness in Type 2 Diabetes Not Well Controlled on Monotherapy in Real Life Practice
The study is designed as non interventional to collect data on the safety especially, severe hypoglycemia or documented symptomatic hypoglycemic episodes and effectiveness of acarbose/metformin fixed-dose combination under…
- Trial name
- GLORY (NCT01915264)
- Testing
- Acarbose/Metformin (Glucobay M, BAY81-9783)
- Sponsor
- Bayer
Type 1 Diabetes
Novel mHealth Physical Activity Intervention for Youth With Type 1 Diabetes Mellitus
The goal of this longitudinal cohort study is to learn about a mHealth intervention in Type 1 Diabetes (T1D) The main question[s] it aims to answer are: Does the intervention increase the amount of text messages between the…
- Trial name
- NCT06018844
- Testing
- NUDGE
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Mercy Hospital Kansas City
Indirect Inguinal Hernia, Undescended Testis
INVESTIGATION OF THE GENETIC ETIOLOGY OF HERNIA SAC DEVELOPMENT IN MALE CHILDREN WITH UNDESCENDED TESTIS AND INGUINAL HERNIA
The aim of the project is to elucidate the genetic etiology underlying the development of the processus vaginalis (PV) in male children with indirect inguinal hernia (IIH) and undescended testis (UT), through the investigation of…
- Trial name
- NCT07586332
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Trakya University
Diabetes Mellitus, Type 1
Super-Bolus: Effects on Postprandial Glycemia After High Glycemic Index Meal
The aim of this study is to determine whether Super-Bolus is more effective in postprandial glycemic control than Normal-Bolus after the high glycemic index (H-GI) meal in children with type 1 diabetes (T1DM) treated with insulin…
- Trial name
- NCT04019821
- Testing
- Insulin Glulisine, Insulin Aspart, Insulin Lispro
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Medical University of Warsaw
Patient Care, Drug Therapy
Comparison of Two Management Systems in Patients With Type 1 Diabetes (Pediatric SmartHome)
Closed loop technology has been shown to reduce both hypoglycemia and hyperglycemia, as well as reduce glycemic variability. Sensor augmented pump (SAP) therapy means the addition of alerts according to high or low glucose values…
- Trial name
- NCT03815487
- Testing
- Medtronic MiniMed 670G Insulin Pump in Auto Mode, Medtronic MiniMed 670G Insulin Pump without Auto Mode
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetic Nephropathies
Serum Uromodulin and DN Systematic Review and Meta Analysis
Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial.
- Trial name
- NCT06596863
- Testing
- The association of serum uromodulin with DN, The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN
- Where
- Egypt
- Volunteers
- 1,774 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cardiovascular Diseases, Diabetes Mellitus
Long-Term Predictors of Morbidity in Older Age
To use existing longitudinal data from the Chicago Heart Association and Western Electric Company studies to examine adiposity in relation to heart failure, multimorbidity and to examine heart rate in relation to incident…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Heart Diseases, Heart Failure
- Trial name
- NCT00094263
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Head and Neck Cancer
Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer
RATIONALE: Azacitidine may help thyroid cancer cells regain the ability to take up iodine. This would allow the cancer to be detected and treated by radioactive iodine.
- Trial name
- NCT00004062
- Testing
- azacitidine, liothyronine sodium, iodine I 131
- Where
- United States
- Sponsor
- Lucille P. Markey Cancer Center at University of Kentucky
Primary Monosymptomatic Nocturnal Enuresis, Copeptin
Serum Copeptin as Biomarker for Diagnosis and Classification of Polyuric Primary Monosymptomatic Nocturnal Enuresis
Primary monosymptomatic nocturnal enuresis (PMNE) is one of the most common urinary system problems in childhood. The exact pathological mechanism has not been fully elucidated yet, but excessive nocturnal urination is considered…
- Trial name
- NCT07496541
- Testing
- copeptin levels in NP-PMNE, Testing the level of copeptin in patients with NNP-PMNE, Testing the level of copeptin in healthy children
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
ERAS, Pediatric Disorder
Studding the Implementation of ERAS Protocols in Pediatric Surgery
this is a retrospective cohort, descriptive study, investigating the role of ERAS protocols, in pediatric surgery and evaluate the feasibility and effectiveness of implementing these protocols
- Conditions
- ERAS, Pediatric Disorder, Appendicitis, Hydrocele
- Trial name
- NCT04870242
- Testing
- Observational study, non-interventional
- Where
- Jordan
- Volunteers
- 178 people
- Sponsor
- University of Jordan
Diabetes Mellitus Type 1, Adolescents
Psychiatric Disorders Related to Diabetes Mellitus Type 1 Among Children in Egypt
Type 1 diabetes is the most common endocrine disorder in children and adolescents. It is characterised by a deficiency in insulin synthesis and requires daily insulin injections to manage glucose levels.
- Conditions
- Diabetes Mellitus Type 1, Adolescents, Psychiatric Disorders
- Trial name
- NCT05477173
- Testing
- The Strengths and Difficulties Questionnaire (SDQ) Parent Version Parent : It consists of 25 questionnaires used to screen for behavioral problems in children aged 4-17 years.
- Volunteers
- 140 people
- Sponsor
- Assiut University
Type 1 Diabetes Mellitus
Best Timing of Insulin Bolus Before Meals of Different Contents
Post-meal glucose excursions may contribute to the development of diabetes-related complications. These glucose excursions are affected by the food content of the meal and the timing of insulin injection (or insulin pump-bolus)…
- Trial name
- NCT01406496
- Testing
- insulin
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Type 1 Diabetes
Assessing the Impact of Control-IQ Technology
This is a single-centre, mixed-methods, prospective study in pediatric patients with T1D initiating Control-IQ technology on the Tandem t-slim X2 insulin pump.
- Trial name
- NCT04838561
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Children's Hospital of Eastern Ontario
Growth Hormone Deficiency, Dwarfism
rhGH Therapy on Hepatic Drug Metabolism
The purpose of the study is to understand the effect of rhGH therapy on hepatic drug metabolism in children with idiopathic growth hormone deficiency.
- Trial name
- NCT00458991
- Testing
- Dextromethorphan and Caffeine
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Louisville
Diabetes Type 1
Home and School Visits Intervention for Children With DM TYPE 1
Home and school visits by multidisciplinary team will improve metabolic control in kids having insulin dependent diabetes mellitus
- Trial name
- NCT02137174
- Testing
- Home and school visits
- Where
- Israel
- Volunteers
- 92 people
- Sponsor
- Ben-Gurion University of the Negev
Turner Syndrome
A Study of PEG-somatropin Injection to Treat Children of Turner Syndrome
This study aims to explore the optimal dose of pegylated recombinant human growth hormone (PEG-rhGH) injection to treat children of Turner syndrome (TS), preliminarily evaluate its safety and efficacy and provide scientific and…
- Trial name
- NCT03189160
- Testing
- PEG-rhGH low dose, PEG-rhGH high dose, Non-treatment control group
- Where
- 9 sites in China
- Volunteers
- 180 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Diabetes
Using Pharmacogenetics to Improve Treatment in Early-onset Diabetes
Monogenic diabetes is an unusual form of diabetes. It usually presents in patients under the age of 30, so is often misdiagnosed as Type 1 diabetes which is more common.
- Trial name
- UNITED (NCT01238380)
- Testing
- patient care pathway
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,916 people
- Sponsor
- University of Exeter
Colorectal Carcinoma, Endometrial Carcinoma
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory).
- Conditions
- Colorectal Carcinoma, Endometrial Carcinoma, Melanoma, Neuroblastoma
- Trial name
- NCT04851119
- Testing
- Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint
- Where
- 21 sites in United States
- Volunteers
- 147 people
- Sponsor
- Children's Oncology Group
Ovarian Cyst
Prognosis and Long Term Pubertal Outcome of Girls Previously Diagnosed With a Prenatal Ovarian Cyst
Puberty and long-term ovarian function of patients with a ovarian prenatal cyst has not described to date.
- Trial name
- KYSTOV (NCT02482467)
- Testing
- Hormonal analysis, pelvic US
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
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