Clinical trials: Extremity
Achondroplasia
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
This is a Phase 2, multicenter, open-label, extension (OLE) study to evaluate the long-term safety, tolerability, and efficacy of infigratinib, an FGFR 1-3-selective tyrosine kinase inhibitor, in participants with ACH who…
- Trial name
- NCT05145010
- Testing
- Infigratinib
- Where
- 31 sites in United States, Argentina and 8 more
- Volunteers
- 325 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Bilateral Upper Limb Amputation, Transverse Short Amputation of the Hand
Bilateral Upper Limb Amputation Observatory
In France, there is currently no data to directly estimate the number of bilateral upper limb amputations, their characteristics and therapeutic care.
- Conditions
- Bilateral Upper Limb Amputation, Transverse Short Amputation of the Hand, Arm Amputation
- Trial name
- ARMOBS (NCT02835378)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Clubfoot
Predictive Value of the PBS-score in Children With Clubfoot
Evaluate the predictive value of the PBS-score in predicting recurrence of idiopathic clubfoot, measured as need for additional treatment.
- Trial name
- NCT06050746
- Testing
- Systematic screening
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Stockholm
Upper Extremity Fractures, Analgesia Post Fracture
Oral Morphine Versus Ibuprofen
Children 5-17 years of age who have sustained a non-operative distal forearm (radius and/or ulna) or clavicular fracture will be randomized to receive either ibuprofen or oral morphine as needed for pain relief for the first 24…
- Trial name
- NCT01690780
- Testing
- Oral morphine, Ibuprofen
- Where
- Canada
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Naveen Poonai
Varicose Veins, Venous Insufficiency
Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery
200 patients with insufficient great saphenous veins will be randomized to either radiofrequency ablation or high ligation/stripping (open surgery).
- Trial name
- NCT02397226
- Testing
- Radiofrequency ablation, High ligation/stripping, Radiofrequency ablation catheter
- Where
- 2 sites in Sweden
- Volunteers
- 198 people
- Sponsor
- University Hospital, Linkoeping
Flatfoot, Flexible
Plyometric vs. Intrinsic Foot Muscle Training in Pediatric Flatfoot
The purpose of this study is to investigate how the order of exercises in a training program affects foot mechanics and physical performance in children with flexible flatfoot.
- Trial name
- NCT07884162
- Testing
- Plyometric Training
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Faculty of Medicine, Sousse
Lower Extremity Muscle Strength
Pro-social Power Training Activity for Aging and Well-being With Chronic Kidney Disease
This is a pilot trial of a 16-week physical activity and power training program among up to 30 Veterans/arm with advanced chronic kidney disease. The trial aims to test whether the program is tolerable to Veterans.
- Trial name
- NCT06089057
- Testing
- Pro-social Power training Activity for Aging and Well-being with Chronic Kidney Disease, Attention Control for Pro-social Power training Activity for Aging and Well-being with Chronic Kidney Disease
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Perinatal Brain Injury
Feasibility of Action Observation Training [AOT] in Infants After Unilateral Brain Lesion
The study examines whether infants with a perinatal unilateral brain lesion can perform an "Action Observation Training" [AOT] at the age of 9-12 months .
- Trial name
- NCT04194281
- Testing
- Action Observation Training [AOT]
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Palsy
Project Falcon: Exploring a Virtual Reality-based Video Game for Young People With Cerebral Palsy
This study seeks to 1) adapt a low-cost controller, the Novint Falcon, and a set of video games that would provide rehabilitative feedback for young people with cerebral palsy, and 2) explore feasibility of the Falcon system and…
- Trial name
- NCT04298411
- Testing
- Falcon
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy
Cerebral Palsy Upper Extremity Orthotic Device
Upper extremity therapies for children with cerebral palsy (CP) have been validated for improving function in higher functioning patients.
- Trial name
- NCT05024409
- Testing
- Upper Extremity Orthotic, Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Cerebral Palsy, Muscle Spasticity
Effects of Repeated Botulinum Toxin Injections in Children With Cerebral Palsy
One of the disorders observed in children with cerebral palsy (CP) is abnormal muscle tone, and the most common tone problem is spasticity.
- Conditions
- Cerebral Palsy, Muscle Spasticity, Vascularization
- Trial name
- NCT05295563
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Gazi University
Clubfoot Deformity, Forefoot Adductus
Outcomes of Eight-Plate Epiphysiodesis for Residual Clubfoot Deformities
Purpose: The purpose of this prospective clinical study is to evaluate the radiographic outcomes, effectiveness, and safety of lateral calcaneocuboid guided growth using an extra-periosteal tension-band plate (eight-plate) to…
- Trial name
- clubfoot (NCT07621328)
- Testing
- Lateral Calcaneocuboid Guided Growth (Eight-Plating)
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Cairo University
Congenital and Acquired Neuromotor Disorders, Developmental Coordination Disorder (DCD)
Pediatric Upper-Limb Rehabilitation With PhiCube, a Modular Bilateral End-Effector Device
The present investigation is configured as a multicenter clinical study in a within-group pilot phase. This study aims to investigate primarily the feasibility of use and effectiveness of a treatment for upper limb function in…
- Trial name
- NCT07092436
- Testing
- Robotic bilateral upper limb rehabilitation training
- Where
- 6 sites in Italy
- Volunteers
- 54 people
- Sponsor
- Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers
Use of Hydroprep Wound Therapy With Motion Negative Pressure Therapy for Treatment of Chronic Lower Extremity Wounds
Use of a motorized waterjet to debride wounds to improve healing outcomes.
- Conditions
- Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers, Pressure Injuries, Traumatic Wounds and Injuries
- Trial name
- NCT07653165
- Testing
- Motion NPWT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- West Boca Center for Wound Healing
Osteosarcoma
ABCB1/P-glycoprotein Expression Influence on Non-metastatic Osteosarcoma of the Extremities
Post-authorization, observational, multicenter and prospective study in patients between 2 and 30 years old diagnosed with non-metastatic high-grade osteosarcoma of the extremities.
- Trial name
- NCT04383288
- Where
- 17 sites in Spain
- Volunteers
- 115 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Adolescent, Foot Posture Index Score
Relationship Between Foot Posture, Toe Flexor Strength, and Balance in Adolescents
The foot plays a critical role in movement and postural control, with toe flexor strength linked to gait, performance, and stability. While these relationships are well studied in adults, evidence in adolescents is limited.
- Conditions
- Adolescent, Foot Posture Index Score, Toe Flexor Strength, Flat Foot Acquired Bilateral (Pes Planus)
- Trial name
- NCT07132424
- Testing
- Assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Unilateral Cerebral Palsy
Impact of Somatosensory Intensive Intervention on Motor Performance in Children With Unilateral Cerebral Palsy
This study aims to investigate the effectiveness of an intensive somatosensory intervention in the upper limb of children with hemiparesis regarding structure, function, activity and participation Hypothesis: Intensive…
- Trial name
- NCT04235088
- Testing
- Somatosensory intensive intervention
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Universidad San Jorge
Pain in Leg, Unspecified, Knee Sprain
Efficacy of Instrumental Chiropractic Treatment Using Activator Methods for Pain and Dysfunction in Juvenile Athletes
The goal of the study is to prove efficacy of instrumental chiropractic treatment for leg pain in juvenile athletes. A randomized placebo controlled clinical trial including juvenile athletes with functional impairment and pain…
- Trial name
- NCT01449994
- Testing
- Activator IV (Activator Methods Int. Phoenix, Arizona)
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Stroke
Effect of Segmental Muscle Vibration on Upper Extremity Functional Ability Post Stroke
Background and objective: Upper extremity functional impairments are common consequences post stroke. The aim of this study was to investigate the influence of Segmental muscle vibration (SMV) application along with supervised…
- Trial name
- NCT03419793
- Testing
- segmental vibration device, physical therapy exercises
- Volunteers
- 37 people
- Sponsor
- University of Rome Tor Vergata
Obstetric Brachial Plexus Injury, Birth Related Brachial Plexus Injury
Investigating the Effectiveness of Graded Motor Imagery Training in Children With Obstetric Brachial Plexus Injury
The aim of this study is to investigate the effect of graded motor imagery training on upper extremity motor function, proprioception, functional mobility, balance and quality of life in patients with obstetric brachial plexus…
- Conditions
- Obstetric Brachial Plexus Injury, Birth Related Brachial Plexus Injury, Neonatal Brachial Plexus Palsy
- Trial name
- NCT06966544
- Testing
- Conventional Physiotherapy, Graded Motor Imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Bakircay University
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