Clinical trials: Extremity
Cerebral Palsy
The Effect of Upper Limb Loading During Partial Body Weight Support Treadmill Training in Children With Cerebral Palsy
Objectives: To look for the effect of upper limb loading with external weights during partial body weight support treadmill training on gait speed, gait endurance and trunk control.
- Trial name
- NCT05444387
- Testing
- Upper limb loading
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Alya Abdelghafour Alkhajeh
Anesthesia, Local, Postoperative Pain
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Pediatrics
In upper extremity surgeries, the brachial plexus block can be performed with different techniques at various levels depending on the proximal and distal level of the surgery.
- Trial name
- NCT04782778
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Chronic Stroke
Error-enhancement for Arm Rehabilitation Post Stroke
Even in a chronic phase after stroke, most patients have difficulty moving the affected arm, resulting in limitations in simple tasks in daily living, most frequently limiting reaching task.
- Trial name
- NCT05229185
- Testing
- DeXtreme training (error-enhancement)
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Childhood Obesity
Biofeedback Gait Retraining to Reduce Lower Extremity Impact in Obese Children
The purpose of the study is to explore if self biofeedback program can reduce ground reaction force (GRF) from the lower extremity of the body and in the knee in particular and help obese children to avoid knee injuries.
- Trial name
- NCT02580825
- Testing
- Biofeedback gait retraining, Exercise
- Where
- Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Hypochondroplasia
An Interventional Study of Infigratinib in Children With Hypochondroplasia
ACCEL2/3 is a Phase 2/3 study. The purpose of the Phase 2 portion of the study (ACCEL2/3) is to evaluate the efficacy and safety of infigratinib in children with hypochondroplasia (HCH) receiving infigratinib at one of two doses…
- Trial name
- HCH (NCT06873035)
- Testing
- infigratinib 0.128 mg/kg/day, infigratinib 0.25 mg/kg/day
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Anisomelia, Deformity of Limb
RSA Study on the Behaviour of the Growth Plate During and After Temporary Hemi-epiphysiodesis and Epiphysiodesis
By using radiostereometric analysis (RSA) we will be able to study growth during and after temporary epiphysiodesis and with great accuracy be able to detect asymmetric growth following this procedure.
- Trial name
- NCT04235517
- Testing
- Temporary hemi-epiphysiodesis or epiphysiodesis
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Adolescent Idiopathic Scoliosis, Upper Extremity
Scapula and Upper Extremity Performance in Scoliosis
Adolescent Idiopathic Scoliosis s a three-dimensional spinal deformity that may alter shoulder girdle alignment, scapular orientation, and upper extremity biomechanics.
- Trial name
- NCT07249515
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istinye University
Joint Hypermobility, Femoral Anteversion
The Effect of Lower Extremity Rotational Profile on Postural Control, Muscle Strength, Functional Capacity and Lower Extremity Function in Children With Generalized Joint Hypermobility
Generalized joint hypermobility is when the range of motion in synovial joints exceeds its physiological limits. The aim of this investigation is to investigate the effect of lower extremity rotational profile on postural…
- Conditions
- Joint Hypermobility, Femoral Anteversion, Postural Control, Lower Extremity Muscle Strength
- Trial name
- NCT06998563
- Testing
- Rotational Profile- Hip Internal and External Rotation Measurement, Rotational Profile- Craig's Test Measurement, Rotational Profile- Foot/Thigh Angle Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cerebral Palsy, Hemiplegic Cerebral Palsy
Effects of Botulinum Toxin Injection on Sensation and Postural Control in Children With Hemiplegic Cerebral Palsy
In this study, the investigators aimed to investigate the effects of botulinum neurotoxin type A (BoNT-A) injection applied to the ankle plantar flexor muscles on lower extremity sensation and quantitative balance parameters in…
- Trial name
- NCT04940143
- Testing
- Botulinum toxin type-A (Onabotulinum toxin type-A), Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Marmara University
Functional Deficits, Manipulation
Effects of Mobilization in Conjunction With Therapeutic Exercise in Participants With a History of Ankle Sprain
Our purpose was to examine the combined effects of thrust mobilization of the proximal and distal ankle joints in conjunction with a six-week rehabilitation program on ankle function in subjects reporting chronic ankle…
- Conditions
- Functional Deficits, Manipulation, Rehabilitation
- Trial name
- NCT02945943
- Testing
- High Velocity Low Amplitude mobilization, Exercise Protocol
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Limb Girdle Muscular Dystrophy
A Gene Transfer Single Dose Study to Evaluate the Safety, Tolerability and Efficacy of SRP-9003 in Non-Ambulatory and Ambulatory Participants With Limb Girdle Muscular Dystrophy, Type 2E/R4 (Beta-Sarcoglycan [β-SG] Deficiency)
The primary purpose of this study is to evaluate the safety of SRP-9003 and to quantify expression of β-SG in the skeletal muscle of participants with limb-girdle muscular dystrophy, type 2E/R4 (LGMD2E/R4).
- Trial name
- NCT05876780
- Testing
- SRP-9003
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Sarepta Therapeutics, Inc.
Cerebral Palsy
Upper Extremity Function In Cerebral Palsy And Its Association With Balance And Trunk Control
Children with cerebral palsy (CP) have postural control problems due to the lack of motor and sensory development. Trunk control which has an important role in ensuring postural control, is the basis for sitting, mobility…
- Trial name
- NCT03179124
- Volunteers
- 62 people
- Sponsor
- Gazi University
Hemiparesis, Hemiplegic Cerebral Palsy
The Impact of Robot Assisted Therapy and Metacognitive Skills Training for Children With Hemiparesis
The Occupational Therapy Department at Boston Children's Hospital is teaming up with MGH Institute of Health Professions to explore the benefits of using robot assisted therapy (Amadeo) and a problem solving approach (Active…
- Conditions
- Hemiparesis, Hemiplegic Cerebral Palsy, Hemiparesis;Poststroke/CVA
- Trial name
- NCT04309266
- Testing
- Amadeo by Tyromotion, Active Learning Protocol for Stroke
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston Children's Hospital
Scoliosis
Relationship Between Spine Coronal Alignment and Lower Limb Biomechanical in Scoliosis
To examine the relationships between spine coronal alignment and lower limb biomechanical parameters in scoliotic adolescents
- Trial name
- NCT06276972
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Delta University for Science and Technology
Pediatric, Neuropathic Pain
Amputations in Childhood and Neuropathic Pain
This observational study aims to assess the presence of neuropathic pain in children and adolescents who underwent limb amputation during childhood.
- Conditions
- Pediatric, Neuropathic Pain, Phantom Limb Pain, Amputation
- Trial name
- NAPE (NCT07401966)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopitaux de Saint-Maurice
Patellofemoral Pain Syndrome, Anterior Knee Pain
Elite Athletes: Trunk Mobility, Lower Extremity Flexibility, and Functional Balance Across Sports
This cross-sectional observational study investigated the relationships among dynamic Q angle, core muscle endurance, hip flexibility, and lower extremity functional status in elite adolescent athletes with and without…
- Trial name
- NCT07326046
- Where
- Cyprus
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Achondroplasia
A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia
This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of infigratinib in children and adolescents with achondroplasia (ACH) who have completed at least 26 weeks of…
- Trial name
- PROPEL3 (NCT06164951)
- Testing
- Infigratinib 0.25 mg/kg/day
- Where
- 27 sites in United States, Argentina and 8 more
- Volunteers
- 114 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Muscular Dystrophies, Limb Girdle Muscular Dystrophy
Biomarker Development in LGMD2i
The overall goal of this natural history study is to define the key LGMD2i phenotypes as measured by standard clinical outcome assessments (COAs), and to validate a muscle biomarker for LGMD2i to support therapeutic development.
- Trial name
- MLB-01-001 (NCT04202627)
- Where
- 11 sites in United States, Denmark
- Volunteers
- 101 people
- Sponsor
- ML Bio Solutions, Inc.
Position Sense, Sex Characteristics
Shoulder Proprioception: a Comparative Study on Hand Dominance and Sex
The goal of this cross-sectional study is to examine the differences in proprioception sensation depending on sex and dominant side factors in healthy volunteers.
- Conditions
- Position Sense, Sex Characteristics, Glenohumeral Joint, Upper Extremity
- Trial name
- NCT06602427
- Testing
- Shoulder proprioception measurement using isokinetic dynamometer
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Parenting, Alopecia
Mindful Parenting - A Single Case Experimental Design Study
Some parents of children living with a visible difference can experience heightened stress due to the associated challenges of this. Parent's views of the child's visible difference and their responses to the child are important.
- Conditions
- Parenting, Alopecia, Skin Condition, Limb Difference
- Trial name
- NCT05779527
- Testing
- Mindful Parenting Programme
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cardiff University
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