Clinical trials: Focus
Mental Disorder in Adolescence, Bipolar Disorder
Investigation of the Effects of Family-Focused Therapy in the Early Period of Bipolar Disorder and Psychotic Disorder
Family-focused therapy (FFT) is a comprehensive therapy approach applied to individuals and their families. In the present study, the researchers aimed to investigate the effects of family-focused therapy (FFT) in the early…
- Conditions
- Mental Disorder in Adolescence, Bipolar Disorder, Psychosis, Family Relations
- Trial name
- NCT05809193
- Testing
- Family-Focused Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Dokuz Eylul University
Epilepsy
A Study to Evaluate the Efficacy and Safety of Perampanel Monotherapy in Untreated Participants With Focal Onset Seizures With or Without Focal to Bilateral Tonic-clonic Seizures
The primary purpose of this study is to evaluate the efficacy of perampanel monotherapy measured by the seizure-free rate during the Maintenance Period (24 weeks) of the Treatment Phase in untreated participants with focal onset…
- Trial name
- NCT05533814
- Testing
- Perampanel
- Where
- 10 sites in South Korea
- Volunteers
- 125 people
- Sponsor
- Eisai Korea Inc.
Morphea
Genetic Variants in Linear Localized Scleroderma
The purpose of this study is to investigate the genetic architecture of Linear Localized Scleroderma (LLS) (linear morphea) by whole exome sequencing.
- Trial name
- NCT02222038
- Testing
- skin biopsy
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University Children's Hospital, Zurich
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
FUS Etoposide for DMG
The blood brain barrier (BBB) prevents some drugs from successfully reaching the target tumor. Focused Ultrasound (FUS) using microbubbles and neuro-navigator controlled sonication is a non-invasive method of temporarily opening…
- Trial name
- NCT05762419
- Testing
- Etoposide; Oral, 50 Mg, Focused ultrasound with neuro-navigator-controlled sonication
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Post-Traumatic Stress Disorder in Children
Evaluating Effectiveness of Dyadic Prolonged Exposure on 2-4 Years Old vs. Toddler-parent Focused Treatment
Traumatic events have potentially debilitating long-lasting effects on the child's normal development and, therefore, should be effectively treated.
- Trial name
- NCT02226393
- Testing
- Prolonged exposure, Child-parent Play Therapy
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Association for Children at Risk
Child Behavior Problem
Effectiveness of the Social-Emotional Prevention Program Enhanced Version
The current study is intended to investigate the effectiveness of the Social-Emotional Prevention Program enhanced version (SEP+) for increasing preschoolers' social-emotional competencies and reducing their risk for behavior…
- Trial name
- SEP+ (NCT05057728)
- Testing
- Social-Emotional Prevention Program enhanced version
- Where
- Romania
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Neuroblastoma
Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00025428
- Testing
- carboplatin, cyclophosphamide, doxorubicin hydrochloride
- Where
- 12 sites in Austria, Belgium and 10 more
- Volunteers
- 100 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Personality Disorders
Biological Effects of Schema Therapy
Background: The major aim of this study is to compare the effects of emotion focused (experiential) and cognitive interventions of schema therapy (ST) on emotion regulation deficits in patients with borderline personality…
- Trial name
- BE-ST (NCT06367907)
- Testing
- schema therapy
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Perinatal Mortality
Low-dose High-frequency Training of Facility Health Care Providers in Mali
This 3-arm cluster randomized trial (C-RCT) has the following objectives: Primary Aim To evaluate the effectiveness of an on-site case-based focused low-dose high-frequency training strategy in a primary health care facility…
- Trial name
- NCT03656237
- Testing
- Usual Training, Audits + LDHF Training
- Where
- Mali
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome
Olanzapine in the Prevention and Treatment of Anorexia-Cachexia Syndrome in Patients Receiving Neoadjuvant/Preoperative Chemotherapy
The goal of this clinical trial is to learn if olanzapine works to prevent and treat anorexia-cachexia syndrome and appetite loss in cancer patients.
- Conditions
- Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome, Oncology
- Trial name
- NCT07633236
- Testing
- OLANZapine 2.5 MG
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Scleroderma, Localized
Imiquimod in Children With Plaque Morphea
Morphea is very hard to treat. In a small number of adult patients, Imiquimod has proven to be beneficial in decreasing the thickness of the morphea plaques , while improving their appearance.
- Trial name
- NCT00147771
- Testing
- Imiquimod 5% cream
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Communication, Multidisciplinary
The Effect of Communication Training on the Communication Skills of the Students
Patient safety, which is an important concept in terms of providing effective and high-quality health care, is defined as "preventing health care errors and eliminating or reducing patient damage caused by health care errors".
- Trial name
- NCT05187598
- Testing
- Effective communication training in perinatal patient safety
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Leukemia, Lymphoma
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
This trial collects feedback from patients to develop a video game in improving the outcomes in stem cell transplant survivors. A video game may help to improve health behaviors for leukemia or lymphoma patients after stem cell…
- Trial name
- NCT01608152
- Testing
- Focus Group, Internet-Based Intervention, Interview
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- M.D. Anderson Cancer Center
Depression, Postpartum
Look - Your Baby is Talking to You.
It is well documented that the formation of the early relation between parents and infant has a significant impact on the child's mental, social and cognitive development and competencies.
- Trial name
- NCT04169334
- Testing
- Prolonged planned program for the stay at the obstetric department
- Where
- Denmark
- Volunteers
- 121 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Sensorimotor Disorder
Improving Postural Control Through Innovative Stimulation of the Proprioceptive System
Every movement humans make in everyday life is based on a continuous integration of sensory information. A good interaction between sensory processes and motor control, called sensorimotor integration, is necessary for the…
- Trial name
- IMPULSES (NCT05367791)
- Testing
- POSTUR, Localised Vibration, Somatosensory Electrical Stimulation
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Mood Disorders, Bipolar Disorder
Technology Enhanced Family Treatment
The investigators propose to enhance the scalability of family-focused therapy (FFT), a 12-session evidence-based therapy for youth at high risk for mood disorders, through augmentation with a novel mobile phone application…
- Conditions
- Mood Disorders, Bipolar Disorder, Major Depression
- Trial name
- NCT03913013
- Testing
- Family-Focused Treatment with MCC App
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Neuroblastoma
Combination Chemotherapy and Surgery With or Without Radiation Therapy in Treating Patients With Stage 2 or Stage 3 Neuroblastoma
RATIONALE: Drugs used in chemotherapy, such as vincristine, cyclophosphamide, cisplatin, etoposide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- NCT00416676
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Volunteers
- 30 people
- Sponsor
- Children's Cancer and Leukaemia Group
Epilepsy
Evaluation of Functional MRI and DTI (Imaging Techniques) in Children With Epilepsy and Focal Brain Lesions
This study is being done to look at the relationship between brain structure and brain function in patients with epilepsy or focal brain lesions (abnormal areas) that require surgery.
- Trial name
- NCT00229840
- Testing
- Functional MRI, Diffusion Tensor Imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Healthcare of Atlanta
Posttraumatic Stress Disorder
Stepped Care for Young Children After Trauma
The aim of this R34 study is to develop and test the feasibility of a Stepped Care intervention for young children with Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01603563
- Testing
- Stepped Care TF-CBT, Standard TF-CBT
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of South Florida
Liver Cancer, Metastatic Cancer
Chemotherapy in Treating Patients With Unresectable Primary or Metastatic Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of pyrazoloacridine in treating patients who have…
- Trial name
- NCT00003714
- Testing
- Pyrazoloacridine
- Sponsor
- M.D. Anderson Cancer Center