Clinical trials: Folate
Malaria
The Effect of Folic Acid on Efficacy of Sulfadoxine-pyrimethamine in Pregnant Women in Western Kenya
The purpose of this study is to determine whether folic acid, which is often routinely given to pregnant women to prevent birth defects and anemia, affects the efficacy of sulfadoxine-pyrimethamine, another drug that is routinely…
- Trial name
- NCT00130065
- Testing
- Sulfadoxine-pyrimethamine/folic acid
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Centers for Disease Control and Prevention
Neurodevelopmental Disorders, Autism Spectrum Disorder
Patterns of Neurodevelopmental Disorders
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome
- Trial name
- NCT06213090
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Richard Frye
Preterm Labor, Small for Gestational Age at Delivery
Calcium Aspirin Multiple Micronutrients (CAMMS) to Reduce Preterm Birth
This trial will evaluate the impact of an integrated intervention of daily maternal calcium, aspirin, and multiple micronutrients (CAMMS) compared to iron-folic acid (IFA) during pregnancy on preterm birth and other adverse birth…
- Conditions
- Preterm Labor, Small for Gestational Age at Delivery, Hypertensive Disorder of Pregnancy, Low Birth Weight
- Trial name
- CAMMS (NCT05612984)
- Testing
- Calcium aspirin multiple micronutrients, Iron-folic Acid
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Autism Spectrum Disorder
Folinic Acid in Autism
An examination of changes in urinary metabolites with use of folinic acid in children with autism spectrum disorder (ASD). Investigators will also measure behavioral measures and academic measures monthly at school with teachers…
- Trial name
- NCT03771560
- Testing
- folinic acid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Contraception
INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)
The study compares the risks of short- and long-term use of contraceptives containing drospirenone (DRSP) or dienogest (DNG)/ethinylestradiol (EE) plus levomefolate calcium (metafolin) with the risks of short- and long-term use…
- Trial name
- NCT01266408
- Where
- Germany
- Volunteers
- 82,921 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Human Cancers
Phase I Study of MOv18 IgE
This first in human study of the new therapeutic antibody MOv18 immunoglobulin (Ig) E, which targets a protein called folate receptor alpha (FRa), in patients with advanced cancer seeks to demonstrate the potential for the use of…
- Trial name
- NCT02546921
- Testing
- MOv18 IgE
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Cancer Research UK
Celiac Disease
Celiac Disease and Vitamin Status: Evaluation of the Effect of Supplementation With a Probiotic (VIVOMIXX®) in a Cohoort of Celiac Patients
Celiac disease is a disorder caused by a disregulation of the immune system which leads to immune response to gluten. Diet therapy is the gold standard of treatment, and the only effective one.
- Trial name
- VIVOMIXX (NCT04160767)
- Testing
- Probiotic Vivomixx, Gluten free diet
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Milan
Osteosarcoma
A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma
The purpose of this study is to see if a new treatment could help patients who have osteosarcoma that does not go away with treatment (is refractory) or comes back after treatment (is recurrent).This study is testing a…
- Trial name
- NCT05312411
- Testing
- SCRI-E2CAR_EGFRtv1, UB_TT170
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Anemia
Periconceptional Iron Supplementation in Rural Bangladesh
The investigators hypothesize that periconceptional iron supplementation to married, nulliparous women in rural Bangladesh will significantly reduce anemia and improve hemoglobin concentrations before and during pregnancy.
- Trial name
- NCT00953134
- Testing
- Ferrous fumarate (iron), folic acid
- Where
- Bangladesh
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Conotruncal Cardiac Defects
Conotruncal Cardiac Defects and Nutrigenetic Etiopathogeny
The investigators planned to study the etiopathogenic factors of conotruncal cardiac defects regarding the relations between the metabolic, the genetic and the environmental factors which lead to these cardiopathy.
- Trial name
- CCOMET (NCT01460316)
- Testing
- Bood sampling for biochemicals and genetic analysis
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy Children
An Investigator-initiated Trial to Assess the Effectiveness of Three Different Gummies (Curcumin Gummies, Vitamin C Gummies, and Vitamin B Complex Gummies) in Healthy Children
An Open-Label, Three-Arm, Parallel, Investigator-Initiated Trial of Three Different Gummies (Curcumin Gummies, Vitamin C Gummies, and Vitamin B Complex Gummies) in Healthy Children.
- Trial name
- NCT05775237
- Testing
- Curcumin Gummies, Vitamin C Gummies, Multivitamin Gummies
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Dietary Habits
Acceptability of Folic Acid and Vitamin B12 Fortified Meals
Evaluation of sensory acceptability of fortified products prior to distribution is essential. We aim to evaluate whether fortification affects sensory qualities and whether these are acceptable to rural communities.
- Trial name
- NCT06094049
- Testing
- Preference test group, Triangle test group
- Where
- 2 sites in Ethiopia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Ghent
Autism Spectrum Disorder, Autistic Disorder
A Folinic Acid Intervention for Autism Spectrum Disorders
Researchers at Arkansas Children's Hospital Research Institute are conducting a study looking at the effects of Folinic Acid on language in Autism Spectrum Disorder and language impairment. The study has 3 phases.
- Conditions
- Autism Spectrum Disorder, Autistic Disorder, Autism, Asperger's Syndrome
- Trial name
- NCT01602016
- Testing
- Folinic Acid
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Arkansas
Adverse Effect of Other General Anesthetics
Folic Acid Intervention During Recovery
Research purposes：Comparison of preoperative folic acid and placebo intervention on postoperative recovery of sputum in children undergoing general anesthesia for head and neck and maxillofacial surgery Test type：Randomized…
- Trial name
- NCT04135885
- Testing
- Folic Acid
- Volunteers
- 300 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Type 1 Diabetes
D-chiro-Inositol in Overweight Type 1 Diabetes Patients
The purpose of this pilot study was to evaluate the effect of D-chiro-Inositol (DCI) oral supplementation in addiction to folic acid compared to folic acid alone on glycaemic control as assessed by HbA1c in overweight or obese…
- Trial name
- NCT02730949
- Testing
- D-chiro-inositol, Folic Acid
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Campus Bio-Medico University
Antenatal Care
Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis
Pregnancy increases the risk of malaria and nutritional deficiency. Despite some progress in ANC access over the past years, coverage of antenatal iron and folic acid supplementation (AIFAS) and intermittent preventive treatment…
- Trial name
- AIFASMaP (NCT04250428)
- Testing
- Demand intervention, Supply intervention
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Centre Suisse de Recherches Scientifiques en Cote d'Ivoire
Diarrhoea;Acute
Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age
Folic acid is a palatable and easily available drug with no serious adverse effects. L-methylfolate is its biologically activated form and is preferred because of its direct availability for certain metabolic processes.
- Trial name
- NCT04782037
- Testing
- L-Methylfolate Calcium
- Where
- Pakistan
- Volunteers
- 324 people
- Sponsor
- King Edward Medical University
Hyperhomocysteinemia, Obesity
Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children
The purpose of the present study was to determine whether folic acid supplementation could reduce plasma homocysteine in obese children and to determine the association between dietary folate, serum folate and homocysteine level…
- Trial name
- NCT01766310
- Testing
- Folic Acid
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Queen Sirikit National Institute of Child Health
First Episode Psychosis
Efficacy of Treating First Episode Psychosis With Folic Acid,B12 and B6 in Addition to Antipsychotic Medication
The purpose of this study is to determine whether Vitamin B12,B6 and Folic Acid are effective with antipsychotic medication in the treatment of First Episode Psychosis.The B-complex Vitamins' homocysteine lowering properties may…
- Trial name
- NCT00202280
- Testing
- Folic Acid 5mg, Vitamin B12 0.4mg and B6 50mg
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Melbourne Health