Clinical trials: Functional Colonic Disease
Irritable Bowel Syndrome
Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome
The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome.
- Trial name
- NCT01268709
- Testing
- Doxepin, Nortriptyline
- Where
- Iran
- Sponsor
- Qom University of Medical Sciences
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Irritable Bowel Syndrome
Effect of Curcumin on Gut Microbiota in IBS
To evaluate the effect of curcumin food supplement on gut microbiota of children with irritable bowel syndrome (IBS) and to review any correlation between the changes in the microbiota with symptoms.
- Trial name
- NCT03568513
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Irritable Bowel Syndrome
The FAIS-Trial: Faecal Microbiota Transplantation (FMT) in Adolescents With Refractory Irritable Bowel Syndrome (IBS)
A Double-blind randomised placebo-controlled pilot study as well as a reversed translational part To investigate whether two faecal transplantations from either allogeneic (healthy) or autologous (own) donor, administered through…
- Trial name
- FAIS (NCT03074227)
- Testing
- Allogeneic faecal transplantation, Autologous faecal transplantation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Probiotics as Adjuvant Therapy in the Management of Irritable Bowel Syndrome
Studying the effects of adding probiotics to the drug regimen of patients with diarrhea predominant IBS
- Trial name
- NCT05523427
- Testing
- Two probiotic strains (L. plantarum and L. acidophilus)
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University of Mosul
Hirschsprung's Disease (HD)
Neuropsychological Development and Functional Outcome Sin Children With Hirschsprung Disease at School Age
Hirschsprung's disease (HD) is a rare congenital disease (1:5000) characterized by neonatal functional low bowel obstruction that is caused by aganglionosis of the distal bowel.
- Trial name
- Hirschsprung (NCT03406741)
- Testing
- psychometric evaluation, neuropsychological evaluation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Irritable Bowel Syndrome
Probiotics in the Treatment of Irritable Bowel Syndrome
The aim of the present study is to assess the efficacy of two different probiotic products, lacto-fermented sauerkraut and the supplement Mutaflor, in the treatment of irritable bowel syndrome.
- Trial name
- NCT02953171
- Testing
- Raw, lacto-fermented sauerkraut, Mutaflor, Pasteurized sauerkraut
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- University of Copenhagen
Ulcerative Colitis
COLISURG : Exploratory Analysis of Sexual Function and the Impact of Biotherapies on Postoperative Morbidity.
The surgical treatment of the ulcerative colitis (UC) remains associate to a significant morbidity (up to 60%). Anastomotic fistula and pelvic sepsis are the most severe complications which could dramatically compromise the…
- Trial name
- COLISURG (NCT03504930)
- Testing
- Impact of biotherapy on postoperative morbidity in ulcerative colitis
- Where
- 22 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
Irritable Bowel Syndrome
Randomised Double-blind Active vs. Placebo Clinical Trial on the Effect of a Food Supplement on IBS in Children
The goal of this clinical trial is to test a food supplement in children of 3-17 years with IBS. The main questions it aims to answer are: Is the tested supplement able to improve and/or reduce IBS-related symptoms? After…
- Trial name
- NCT06123234
- Testing
- Verum
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Crohn's Disease
Long-term Safety Study of Brodalumab in Adults With Crohn's Disease
The purpose of this study is to evaluate the safety and efficacy of long-term treatment with brodalumab in adults with Crohn's disease.
- Trial name
- NCT01199302
- Testing
- Brodalumab
- Where
- 34 sites in United States, Australia and 6 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Functional Gastrointestinal Disorders (FGID), FGID According to the Rome III Criteria
Cognitive Behavior Therapy (CBT) for Children With Functional Gastrointestinal Disorders
The purpose of the trial is to develop a treatment protocol to be used in trials studying internet-delivered CBT for children with functional gastrointestinal disorders (FGID).
- Conditions
- Functional Gastrointestinal Disorders (FGID), FGID According to the Rome III Criteria, Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
- Trial name
- CBT (NCT02113605)
- Testing
- Cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Functional Abdominal Pain Disorder
Low-FODMAP Diet for Functional Abdominal Pain Disorders in Children.
This single-center, randomized, controlled, quadruple-blinded, superiority trial is performed to test the hypothesis that children with IBS and FAP-NOS who receive a low-FODMAP diet will have a lower mean abdominal pain intensity…
- Trial name
- NCT04528914
- Testing
- Low-FODMAP diet
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Medical University of Warsaw
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Diseases, Crohn Disease
Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)
This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- STRIDE (NCT06315179)
- Testing
- Esophagogastroduodenoscopy (EGD) with biopsy, Colonoscopy w/ biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Crohn Disease, Ulcerative Colitis
OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome
Study Aims: To analyze stool specimens to test and validate the CalproLab assay against the predicate PhiCal in order to determine performance characteristics. And to correlate Calpro levels to the gut microbiome composition.
- Conditions
- Crohn Disease, Ulcerative Colitis, Irritable Bowel Syndrome, Celiac Disease
- Trial name
- OptiCal (NCT03051204)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Functional Abdominal Pain Syndrome
The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders
Recurrent or chronic abdominal pain is one of the common gastrointestinal problems in children. While most children do not have organic origins (so called functional abdominal pain disorders; FAPDs), the symptoms can nevertheless…
- Trial name
- NCT06310733
- Testing
- LGG
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Irritable Bowel Syndrome, Dyspepsia Chronic
Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders
Abdominal pain (AP)-associated functional gastrointestinal disorders (FGIDs), particularly Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD), are common in pediatrics, and no safe and effective treatment is available.
- Trial name
- NCT02566876
- Testing
- Mixture of three Bifidobacteria
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Federico II University
Functional Abdominal Pain, Irritable Bowel Syndrome
Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain
IND application was submitted to FDA on November 17th.
- Conditions
- Functional Abdominal Pain, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- FAP (NCT01269671)
- Testing
- Melatonin, Peppermint Oil (mentharil), and Simethicone, Sugar pill
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Irritable Bowel Syndrome
Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood.
- Trial name
- NCT00235326
- Where
- Canada
- Volunteers
- 4,561 people, healthy volunteers welcome
- Sponsor
- McMaster University
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University