Clinical trials: GI Disorders
Stress, Irritable Bowel Syndrome
Evaluating and Treating Potential Research Participants With Digestive Disorders
Background: Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these…
- Conditions
- Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
- Trial name
- NCT01736280
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
GI Cancer
Prevalence of Types and Patterns of Gastrointestinal Polyps in Assiut University Hospitals ( Cross Sectional Study
Gastrointestinal polyps (GIPs) are unusual growths of epithelial tissue projecting from the mucosa of gastrointestinal tract (GIT) and one of the most common pathologies affecting GIT .
- Trial name
- Polyp (NCT06929117)
- Volunteers
- 130 people
- Sponsor
- Assiut University
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors
Screening for Disorders of Lipid Metabolism and Familial Hyperlipidemia in Children and Adolescents With Increased Cardiovascular Risk Due to Chronic Diseases Such as Congenital Heart Disease, Chronic Inflammatory Bowel Disease, Celiac Disease and Rheumatic Disorders
Preventive measures are increasingly coming to the forefront of medicine. Many of these measures can be implemented as early as childhood and adolescence.
- Conditions
- Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Congenital Heart Disease, Inflammatory Bowel Disease (IBD)
- Trial name
- FAMELIPIDCHILD (NCT07716488)
- Testing
- blood test, questionaire
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Alexandra Miriam Kiess
Rectal Neoplasms
Palliative Short-Course Radiotherapy in Rectal Cancer
Radiotherapy (RT) is a potentially effective method in the treatment of symptoms of rectal carcinomas. Nevertheless, almost all the evidences about palliative RT in rectal cancer have been published more than two decades ago and…
- Trial name
- NCT02639403
- Testing
- Conformal three-dimensional Radiotherapy
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sentinel Lymph Node, Early Gastric Cancer
Feasibility Study of Sentinel Navigation Surgery After Non-curative Endoscopic Resection
Purpose: To prove the feasibility of sentinel node navigation surgery (SNNS) in early gastric cancer patients with the risk of lymph node metastasis after endoscopic resection and preparation of multicenter phase 3 trial of…
- Trial name
- SENORITA2 (NCT03123042)
- Testing
- Sentinel basin dissection
- Where
- 9 sites in South Korea
- Volunteers
- 243 people
- Sponsor
- National Cancer Center, Korea
Colorectal Neoplasms
Diagnostic Value of Endocytoscopy for Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and resection of…
- Trial name
- NCT06324097
- Testing
- endocytoscopy
- Where
- China
- Volunteers
- 463 people
- Sponsor
- Hong Xu
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Probiotics as Adjuvant Therapy in the Management of Irritable Bowel Syndrome
Studying the effects of adding probiotics to the drug regimen of patients with diarrhea predominant IBS
- Trial name
- NCT05523427
- Testing
- Two probiotic strains (L. plantarum and L. acidophilus)
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University of Mosul
Crohn Disease, Infliximab
Combined Immunosuppression for Pediatric Crohn's Disease
This is a randomized controlled trial to compare the efficacy and safety of infliximab and immunosuppressives therapy alone or in combination for pediatric Crohn's disease.
- Conditions
- Crohn Disease, Infliximab, Immunosuppression, Children, Only
- Trial name
- NCT05043870
- Testing
- Infliximab and immunosuppressives, Infliximab
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Children's Hospital of Fudan University
Oesophageal Cancer
Study of Chemoradiotherapy in Oesophageal Cancer Including PET Response and Dose Escalation
Research has shown that increasing the dose of radiotherapy improves outcomes in patients with lung and head and neck cancers. This study aims to see whether this is also the case for patients with tumour of the oesophagus.
- Trial name
- SCOPE2 (NCT02741856)
- Testing
- Carboplatin, Paclitaxel, Cisplatin
- Where
- 26 sites in United Kingdom
- Volunteers
- 584 people
- Sponsor
- Lisette Nixon
Colorectal Cancer, Postoperative Complications
Measuring Quality in Colorectal Cancer Surgery in Low- and Middle-income Countries
To test the applicability of the Clavien-Dindo Classification (CDC) in an LMIC setting and to compare the prevalence and severity of complications in patients <60 and ≥60 years of age a retrospective medical records review is…
- Conditions
- Colorectal Cancer, Postoperative Complications, Surgical Complication, Non-communicable Disease
- Trial name
- NCT05182762
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Eosinophilic Esophagitis, EoE
Dupilumab for Eosinophilic Esophagitis With Severe Strictures
The purpose of this research study is to determine how well an FDA-approved drug, dupilumab, works to treat patients with severe strictures and active Eosinophilic Esophagitis (EoE).
- Trial name
- DESTRICT (NCT06352073)
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Gastrointestinal Diseases
The Effects of an Infant Formula Containing Probiotic CECT7210 on Gastrointestinal Health
The purpose of this study is to determine whether an infant formula supplemented with a new probiotic CECT7210, is effective in reducing the incidence of infections, specially the gastrointestinal ones.
- Trial name
- GO-INF (NCT02096302)
- Testing
- Infant Formula with a novel probiotic CECT7210, Standard formula
- Where
- 3 sites in Spain
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Laboratorios Ordesa
Colorectal Cancer, Microsatellite Instability
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact
MSI (Microsatellite Instability) colorectal cancer (CRC) show improved survival, are less prone to metastasis and show poor response to chemotherapy (compared to MSS tumors).
- Trial name
- NCT03447431
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease, Active, Crohn's Disease (CD)
Tailored Anti-Inflammatory American Diet for Patients With Crohn's Disease
The purpose of this study is to test the effect of an anti-inflammatory diet tailored for patients living in the United States with Crohn's Disease (CD) on clinical symptoms and disease inflammation and to identify biomarkers of…
- Conditions
- Crohn's Disease, Active, Crohn's Disease (CD), Diet Interventions
- Trial name
- NCT07671872
- Testing
- Catered Anti-Inflammatory Diet, Diet Guidance for Usual Diet
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Miami
Colorectal Neoplasm
A LAparoscopic and TransAnal Total Mesorectal Excision (TME) for Rectal Cancer Trial
All patients planned for an anterior resection due to rectal cancer with a total mesorectal excision are included. This is a feasibility study, thus no randomization will be performed.
- Trial name
- LATA (NCT02324556)
- Where
- 2 sites in Sweden
- Volunteers
- 6 people
- Sponsor
- Sahlgrenska University Hospital
Short Bowel Syndrome
Fiber Use in Pediatric Short Bowel Syndrome
Short bowel syndrome (SBS) is a form of disease that results from removal of a significant portion of the intestine leading to poor nutrient absorption. Infants with short bowel syndrome suffer from diarrhea and poor growth.
- Trial name
- NCT00922805
- Testing
- guar gum
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute
Colorectal Cancer
Genetic Markers in Patients With Colorectal Cancer
RATIONALE: Determination of genetic markers for colorectal cancer may improve the identification of patients who are at highest risk for relapse.
- Trial name
- NCT00014079
- Testing
- DNA stability analysis, loss of heterozygosity analysis, microsatellite instability analysis
- Where
- 3 sites in United States
- Volunteers
- 675 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophagitis, Eosinophilic Esophagitis
Eosinophilic Esophagitis Databank
This study will establish a registry for participants with eosinophilic esophagitis (EoE) and create a research resource that will provide further insights into EoE.
- Trial name
- CoFAR5 (NCT01323803)
- Where
- 5 sites in United States
- Volunteers
- 709 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Lymphoblastic Leukemia, Pediatric, Obesity, Pediatric
Low GI Diet in Children and Adolescents With ALL
The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for acute lymphoblastic leukemia.
- Trial name
- NCT03157323
- Testing
- Low Glycemic Index Diet
- Where
- 5 sites in United States
- Volunteers
- 88 people
- Sponsor
- Columbia University
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