Clinical trials: GI Disorders
Otitis Media With Effusion
Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion
The aim of the study was detection of pepsin in effusion in children with OME using Peptest as new quick and cheap method of detection and comparison results with results of other studies in which pepsin was detected by more…
- Trial name
- NCT02183974
- Testing
- Peptest
- Where
- Czechia
- Volunteers
- 44 people
- Sponsor
- University Hospital Ostrava
Laryngomalacia, Gastro Esophageal Reflux
Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia
Laryngomalacia (LM) is the most common cause of stridor in infants. Symptoms of gastroesophageal reflux (GER) are often seen in the setting of LM; therefore, acid suppression therapy (AST) has been empirically used in the…
- Trial name
- NCT04614974
- Testing
- Famotidine, Speech Language Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Reema Padia
Short Bowel Syndrome, Complications
Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications
There are no reports involved the intestinal microbiota from Chinese infants with short bowel syndrome (SBS) under different clinical status.
- Trial name
- MSBS (NCT02699320)
- Testing
- Complications
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Inflammatory Bowel Disease
Study Assessing Risk Factors for Abdominal Pain in Children With Inflammatory Bowel Disease
To characterize persistent abdominal pain in children with inflammatory bowel disease (IBD) by examining factors such as disease type, activity and location, psychosocial factors, and genetics.
- Trial name
- NCT02984059
- Testing
- Genomic DNA, RNA analysis, Microbiome
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Connecticut Children's Medical Center
Colorectal Cancer
Curative Proton Beam Therapy for Patients With Lung Metastasis of Colorectal Cancer
Proton alone therapy is performed -> 5 times a week, 7200 cGy / 15 fractions for 3 weeks total
- Trial name
- NCT03566355
- Testing
- curative proton therapy
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- National Cancer Center, Korea
Gastroesophageal Reflux Disease
A Study to Evaluate the Effect of Lansoprazole on Infants With Gastroesophageal Reflux Disease.
The purpose of this study is to understand how quickly lansoprazole, once daily (QD), improves feeding in premature babies or babies less than 28 days of age.
- Trial name
- NCT00220818
- Testing
- Lansoprazole
- Volunteers
- 24 people
- Sponsor
- Takeda
Colo-rectal Cancer
Clinical Study on the Expression of PHGDH and Its Prognostic Value in Colorectal Cancer Patients Receiving Immunotherapy
This study aims to evaluate the expression characteristics of PHGDH in tumor tissues based on the clinical data and pathological tissue samples of colorectal cancer patients who have previously received immunotherapy, and to…
- Trial name
- NCT07508046
- Testing
- No intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Drooling
Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral Dysphagia
Children suffering from neurological problems may have a common problem of drooling and dysphagia.There is high prevelance of neurological disorders in developing countries including Pakistan.Parents of children with disability…
- Trial name
- NCT04266626
- Testing
- kinesiotaping therapy, oral motor manipulation therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Isra University
Celiac Disease
Saliva Composition and Oral Hygiene in Children With Celiac Disease Before and After the Change in Diet
The celiac disease (CD) is a disease with an immune and genetic component that is activated by the presence of gluten, and damages the intestine mucosa and causes malabsorption of food.
- Trial name
- NCT01129908
- Volunteers
- 90 people
- Sponsor
- Hadassah Medical Organization
Crohn Disease (CD), Dynamic Prediction Model
Development of a Dynamic Prediction Model for Crohn's Disease-Related Intestinal Surgery Using Longitudinal Indices of Routine Blood Tests: A Single-Center Retrospective Cohort Study
This single-center retrospective cohort study aims to develop and internally validate a dynamic prediction model that uses longitudinal data from routinely collected blood tests to continuously assess the risk of Crohn's disease…
- Trial name
- NCT07644390
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Peptic Ulcer Hemorrhage
Effect of High-dose Oral Rabeprazole on Recurrent Bleeding After the Endoscopic Treatment of Bleeding Peptic Ulcers
This study is conducted to compare and evaluate the effect of administering a high-dose intravenous proton pump inhibitors or high-dose oral Rabeprazole in preventing recurrent bleeding after the endoscopic treatment of bleeding…
- Trial name
- NCT00838682
- Testing
- omeprazole sodium IV, Rabeprazole
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- The Catholic University of Korea
Necrotizing Enterocolitis, Very Low Birth Weight Infants
Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants
Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system and stimulate the immune system. Necrotizing enterocolitis incidence is 10-25% in newborn infants whose birth weights are < 1500 g.
- Trial name
- NCT01531179
- Testing
- Lactobacillus reuteri
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Crohn's Disease
Artificial Intelligence-Based Classification and Prognostic Prediction in Small Bowel Crohn's Disease
This retrospective observational study aims to develop an artificial intelligence-based system for the precise classification and prognostic prediction of small bowel Crohn's disease.
- Trial name
- NCT07757217
- Testing
- Artificial Intelligence-Based Multimodal Analysis
- Where
- China
- Volunteers
- 437 people
- Sponsor
- Shanghai 10th People's Hospital
Celiac Disease
Study of the NATURal History, Epidemiological, Clinical, Diagnostic and Therapeutic Aspects of CELiac Disease and Non-celiac Enteropathies
Celiac disease is a chronic immune-mediated enteropathy triggered by gluten intake, which affects the small intestine in genetically susceptible subjects (HLA-DQ2 and/or HLA-DQ8).
- Trial name
- NATURCEL (NCT07070596)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Mutua de Terrassa
Colorectal Cancer, Refractory Colorectal Cancer
Fruquintinib in Refractory Metastatic Colorectal Cancer: A Real-world Study
Fruquintinib is an oral tyrosine kinase inhibitor (TKI), which improves progression-free survival (PFS) and overall survival (OS) in patients with refractory metastatic colorectal cancer (mCRC).
- Conditions
- Colorectal Cancer, Refractory Colorectal Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT06202417
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Gastric Cancer, Neoadjuvant Chemotherapy
The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments
Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer.
- Conditions
- Gastric Cancer, Neoadjuvant Chemotherapy, Neoadjuvant Chemoradiotherapy, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- NCT03493880
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University
Gastroesophageal Reflux Disease, Excessive Weight Loss
Sleeve Gastrectomy With Reestablishment of the Acute Angle of His (SG-REACH) in Obese Patients
Gastroesophageal reflux disease (GERD) is one of the most common chronic conditions that can affect one's quality of life. Laparoscopic sleeve gastrectomy (LSG) has become a popular technique and currently is the most frequently…
- Conditions
- Gastroesophageal Reflux Disease, Excessive Weight Loss, Total Weight Loss, Sleeve Gastrectomy
- Trial name
- SG-REACH (NCT05452980)
- Testing
- reestablishment of the acute angle of His, sleeve gastrectomy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhen Jun Wang
Familial Adenomatous Polyposis, Colorectal Cancer
Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)
The goal of this research study is to test the first version of a website that will offer information and support for adolescents and young adults with FAP.
- Trial name
- NCT00525655
- Testing
- Web-Based Multimedia Intervention, Questionnaire
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer (CRC), Surgery, Colorectal
Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lymphadenectomy
This study is a randomized, controlled trial comparing the short- and long-term outcomes of left colonic artery or first sigmoid artery preservation for rectal surgery.
- Conditions
- Colorectal Cancer (CRC), Surgery, Colorectal, Oncology
- Trial name
- COLAP-D3 (NCT06938490)
- Testing
- Anterior rectal resection with D3-lymphatic dissection
- Where
- Russia
- Volunteers
- 778 people
- Sponsor
- the BELOOSTROV Clinic of High Technologies
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