Clinical trials: General Anesthetics
Endotracheal Extubation, Airway Anesthesia
BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia
During surgery, anaesthetists can use an endotracheal tube (ETT) to facilitate ventilation. At emergence from general anaesthesia, there are two techniques for removal of the ETT: (1) the ETT is removed when the child is waking…
- Conditions
- Endotracheal Extubation, Airway Anesthesia, Paediatric
- Trial name
- BELUGA (NCT07204990)
- Testing
- Direct removal of endotracheal tube, Laryngeal mask airway inserted following deep extubation
- Where
- 8 sites in United States, Australia and 4 more
- Volunteers
- 1,400 people
- Sponsor
- Telethon Kids Institute
Sevoflurane Anaesthesia
Effect of Animated Cartoon for Prevention of Emergence Agitation in Children Aged 1.5 - 5 yr After General Anesthesia
Emergence agitation (EA) in children early after sevoflurane anaesthesia is a common postoperative problem, with incidence ranging up to 80%.
- Trial name
- NCT01880138
- Testing
- watching animated cartoon before general anesthesia, not watching animated cartoon beofre general anaesthesia
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Atrial Septal Defect (ASD), Dexmedetomidine
Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect
The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters.
- Conditions
- Atrial Septal Defect (ASD), Dexmedetomidine, Delirium - Postoperative, Stress Response
- Trial name
- NCT06631534
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
General Anaesthesia, Airway Devices
Sevoflurane Versus Propofol for Laryngeal Mask Airway Placement in Children Undergoing Surgery
The goal of this clinical trial is to compare two commonly used anesthetic medicines, sevoflurane and propofol, for inserting a laryngeal mask airway (LMA) in children undergoing minor elective surgery.
- Conditions
- General Anaesthesia, Airway Devices, Airway Control
- Trial name
- NCT07673003
- Testing
- propofol, Sevoflurane
- Where
- Pakistan
- Volunteers
- 170 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Anesthesia
Comparison of Minimal Fresh Gas Requirements of Baby EAR and Jackson Rees Anesthetic Circuit
The investigators invented the baby enclosed afferent reservoir anesthesia circuit (Baby EAR) which could be used safely in children between 5 and 20 kg, using a fresh gas flow of 2.5 and 3 L/min in the spontaneous breathing and…
- Trial name
- NCT02167269
- Testing
- Baby EAR
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
General Anaesthesia, Propofol
Blood Propofol Measurement During Anaesthesia Using Propofol Target Controlled Infusion
Propofol is a commonly used agent for sedation and anaesthesia in the intensive care unit and the operating room. The pharmacokinetics of propofol are difficult to predict in patients not conforming to the norms in which the…
- Conditions
- General Anaesthesia, Propofol, Target Controlled Infusion, Pharmacokinetics
- Trial name
- NCT01549639
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Postoperative Delirium, Postoperative Pain
Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children
Participants aged 4-10 years (92 patients), who came to the Hospital Operating Room at the University Faculty of Dentistry with an indication for dental treatment under general anesthesia due to lack of cooperation, will be…
- Trial name
- NCT06400706
- Testing
- EEG guided general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Anxiety
EFFECTS OF REPEATED GENERAL ANAESTHESIA ON THE LEVEL OF PRE-PROCEDURE ANXIETY IN CHILDREN UNDERGOING RADIOTHERAPY.
Observation of pre-precedure anxiety in pre-operative suite in children from age 2-12yrs, undergoing radiotherapy under general anesthesia.
- Trial name
- NCT05257304
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Dental Caries
The Use of Pit and Fissure Sealants in Children Requiring Caries Related Dental Extractions
The purpose of thus study is to assess the feasibility and inform the planning of a proposed definitive randomised controlled clinical trial to investigate the efficacy of sealing permanent molars in children requiring caries…
- Trial name
- NCT02443896
- Testing
- Pit and Fissure Sealant of permanent molars, No sealant of permanent molars
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Birmingham
Anesthesia Complication, Tracheostomy Complications
Complications Related to the Anaesthesia During Airway Endoscopy in Children With Tracheostomy.
The goal of this observational study is to investigate the incidence of severe anaesthesiologic complications during anaesthesia in children with tracheostomy undergoing surveillance airway endoscopy.
- Conditions
- Anesthesia Complication, Tracheostomy Complications, Children Receiving General Anesthesia
- Trial name
- NCT06906263
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Pupillary Functions, Abnormal
Effects of Volatile and Intravenous Anesthetics on Pupillary Function
To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children
- Trial name
- NCT03987529
- Testing
- sevoflurane, propofol
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Seoul National University Hospital
General Anesthetic
HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery
This multicenter, randomized, double-blinded, propofol-controlled Phase 3b study enrolls pediatric subjects aged 3-17 years undergoing elective surgery with endotracheal intubation.
- Trial name
- NCT07510945
- Testing
- HSK3486, propofol
- Volunteers
- 400 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Propofol, Ketamine
Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization
Children undergoing cardiac catheterization will be given anesthesia using either a combination of propofol and ketamine or sevoflurane gas. The time taken to fall asleep will be recorded.
- Conditions
- Propofol, Ketamine, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT07907796
- Testing
- Ketamine-Propofol, Sevoflurane
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Rawalpindi Institute of Cardiology
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Postoperative Complications
The Effect of Local Anaesthesia Technique on the Recovery After Dental Treatment in General Anaesthesia
Use of local anaesthesia during full mouth dental rehabilitation under general anaesthesia is an everyday practice. It enables better control of the post-extraction bleeding and better control of physiological responses.
- Trial name
- NCT04156334
- Testing
- Extraction of teeth in general anaesthesia using either computer-controlled intraosseous anesthesia device or carpule for local anaesthesia
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- University of Ljubljana
Anesthesia
What Effect Does Intubation Have on Regional Lung Ventilation?
During any general anaesthetic which involves muscle relaxation artificial breathing is required. This is most commonly provided by pushing air under pressure (positive pressure ventilation) into the lungs via a tube in the…
- Trial name
- NCT03319303
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Neurodevelopmental Disorder, Bilateral Inguinal Hernia
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3…
- Trial name
- DEGA (NCT02559102)
- Testing
- Dexmedetomidine sedation, General sevoflurane anaesthesia, Caudal anaesthesia
- Where
- Singapore
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Tracheal Intubation
Infant Glidescope® Learning Curve
A prospective trial evaluating the learning curve associated with the use of a videolaryngoscope compared to conventional direct laryngoscopy in infants intubated by anesthesiology residents.
- Trial name
- NCT01793727
- Testing
- Glidescope videolaryngoscope
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
General Anesthetic Drug Adverse Reaction
PKPD of Rocuronium and Sugammadex Profile in Pediatric Patients
The aim of the study is to assess the pharmacokinetic and pharmacodynamic properties of rocuronium and sugammadex and their clinical effect in the terms of both the relaxation of paralysed muscles (rocuronium) and the reversal of…
- Trial name
- NCT04851574
- Testing
- Sugammadex Injection
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Poznan University of Medical Sciences
Children, Heart Diseases
Study to Evaluate the Optimal Dose of Remifentanil During MRI of the Heart Under General Anaesthesia
What is the optimal maintenance dose of remifentanil to ensure apnoea, during breath hold episodes in children having cardiac MR imaging with general anaesthesia?
- Conditions
- Children, Heart Diseases, Anaesthesia, Magnetic Resonance Imaging
- Trial name
- NCT02481791
- Testing
- Remifentanil and/or propofol, propofol
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust